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American Journal of Psychiatry

Volume 179, Issue 9

September 2022

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Editor’s Note

September 2022

Combining Molecular and Neuroimaging Measures to Understand Psychopathology and Inform New Treatment Development

Ned H. Kalin, M.D.

Pages:589–592
Published Online:1 September 2022

https://doi.org/10.1176/appi.ajp.20220611

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Editorials

September 2022

Broadening the Parameters of Clinical High Risk for Psychosis

David Cotter, M.D., Ph.D.,
Colm Healy, Ph.D.,
Lorna Staines, B.Sc.,
David Mongan, M.D., Ph.D.,
Mary Cannon, M.D., Ph.D.

Pages:593–595
Published Online:1 September 2022

https://doi.org/10.1176/appi.ajp.20220612

First Page
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September 2022

The Intergenerational Transmission of Anxiety Disorders and Major Depression

Frances Rice, Ph.D.

Pages:596–598
Published Online:1 September 2022

https://doi.org/10.1176/appi.ajp.20220570

First Page
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September 2022

Looking Through a Fog: What Persistent Derealization Can Teach Us About PTSD

Lisa M. Shin, Ph.D.

Pages:599–600
Published Online:1 September 2022

https://doi.org/10.1176/appi.ajp.20220573

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September 2022

Transcriptomic Decoding of Shared and Unshared Molecular Etiologies in Psychiatric Disorders

Sarah A. Rudzinskas, Ph.D.,
David Goldman, M.D.

Pages:601–603
Published Online:1 September 2022

https://doi.org/10.1176/appi.ajp.20220594

First Page
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September 2022

The American Journal of Psychiatry’s Efforts Toward Eliminating Racism, Social Injustice, Health Care Inequities, and Publication Biases

Ned H. Kalin, M.D.,
Elisabeth B. Binder, M.D., Ph.D.,
Kathleen T. Brady, M.D., Ph.D.,
David A. Lewis, M.D.,
William M. McDonald, M.D.,
Daniel S. Pine, M.D.,
Carolyn I. Rodriguez, M.D., Ph.D.,
Michael D. Roy, B.S.

Pages:604–605
Published Online:1 September 2022

https://doi.org/10.1176/appi.ajp.20220598

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APA Presidential Addresses

September 2022

2022 Annual Meeting: Presidential Address

Vivian B. Pender, M.D.

Pages:606–607
Published Online:1 September 2022

https://doi.org/10.1176/appi.ajp.22179005

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September 2022

2022 Annual Meeting: President-Elect Address

Rebecca W. Brendel, M.D., J.D.

Pages:608–609
Published Online:1 September 2022

https://doi.org/10.1176/appi.ajp.22179006

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September 2022

Vivian B. Pender, M.D., 148th President, 2021–2022

Altha J. Stewart, M.D.

Page:610
Published Online:1 September 2022

https://doi.org/10.1176/appi.ajp.22179007

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Reviews and Overviews

September 2022

Muscarinic Acetylcholine Receptor Agonists as Novel Treatments for Schizophrenia

Steven M. Paul, M.D.,
Samantha E. Yohn, Ph.D.,
Michael Popiolek, Ph.D.,
Andrew C. Miller, Ph.D.,
Christian C. Felder, Ph.D.

Pages:611–627
Published Online:27 June 2022

https://doi.org/10.1176/appi.ajp.21101083

Abstract
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Schizophrenia remains a challenging disease to treat effectively with current antipsychotic medications due to their limited efficacy across the entire spectrum of core symptoms as well as their often burdensome side-effect profiles and poor tolerability. ...

Articles

CMEVideo

September 2022

Developmental Pathways and Clinical Outcomes of Early Childhood Psychotic Experiences in Preadolescent Children at Familial High Risk of Schizophrenia or Bipolar Disorder: A Prospective, Longitudinal Cohort Study - The Danish High Risk and Resilience Study, VIA 11

Maja Gregersen, M.Sc.,
Jens Richardt Møllegaard Jepsen, M.Sc., Ph.D.,
Sinnika Birkehøj Rohd, M.Sc.,
Anne Søndergaard, M.Sc.,
Julie Marie Brandt, M.Sc.,
Ditte Ellersgaard, M.D., Ph.D.,
Carsten Hjorthøj, M.Sc., Ph.D.,
Jessica Ohland, M.Sc.,
Mette Falkenberg Krantz, M.D., Ph.D.,
Martin Wilms, M.Sc.,
Anna Krogh Andreassen, M.Sc.,
Lotte Veddum, M.Sc.,
Christina Bruun Knudsen, M.Sc.,
Aja Neergaard Greve, M.Sc., Ph.D.,
Vibeke Bliksted, M.Sc., Ph.D.,
Ole Mors, M.D., Ph.D.,
Lars Clemmensen, M.Sc., Ph.D.,
Merete Nordentoft, M.D., Ph.D.,
Nicoline Hemager, M.Sc., Ph.D.,
Anne Amalie Elgaard Thorup, M.D., Ph.D.

Pages:628–639
Published Online:1 September 2022

https://doi.org/10.1176/appi.ajp.21101076

Abstract
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Objective:Psychotic experiences are common in children and adolescents and are associated with concurrent and subsequent psychopathology. Most findings originate from general population studies, whereas little is known of the clinical outcomes of ...

September 2022

An Extended Swedish Adoption Study of Anxiety Disorder and Its Cross-Generational Familial Relationship With Major Depression

Kenneth S. Kendler, M.D.,
Linda Abrahamsson, Ph.D.,
Henrik Ohlsson, Ph.D.,
Jan Sundquist, M.D., Ph.D.,
Kristina Sundquist, M.D., Ph.D.

Pages:640–649
Published Online:1 September 2022

https://doi.org/10.1176/appi.ajp.21111110

Abstract
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Objective:To clarify, using an extended adoption design, the sources of parent-offspring transmission for anxiety disorder (AD) and its major subforms and their familial cross-generational relationship with major depression (MD).Methods:Offspring (born ...

CMEVideo

September 2022

Schizophrenia Imaging Signatures and Their Associations With Cognition, Psychopathology, and Genetics in the General Population

Pages:650–660
Published Online:12 April 2022

https://doi.org/10.1176/appi.ajp.21070686

Abstract
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Objective:The prevalence and significance of schizophrenia-related phenotypes at the population level is debated in the literature. Here, the authors assessed whether two recently reported neuroanatomical signatures of schizophrenia—signature 1, with ...

CMEAudio

September 2022

Persistent Dissociation and Its Neural Correlates in Predicting Outcomes After Trauma Exposure

Lauren A.M. Lebois, Ph.D.,
Nathaniel G. Harnett, Ph.D.,
Sanne J.H. van Rooij, Ph.D.,
Timothy D. Ely, B.A.,
Tanja Jovanovic, Ph.D.,
Steven E. Bruce, Ph.D.,
Stacey L. House, M.D., Ph.D.,
Caitlin Ravichandran, Ph.D.,
Nathalie M. Dumornay, B.S.,
Katherine E. Finegold, Ed.M.,
Sarah B. Hill, B.A.,
Julia B. Merker, B.S.,
Karlye A. Phillips, B.A.,
Francesca L. Beaudoin, M.D., Ph.D.,
Xinming An, Ph.D.,
Thomas C. Neylan, M.D.,
Gari D. Clifford, D.Phil.,
Sarah D. Linnstaedt, Ph.D.,
Laura T. Germine, Ph.D.,
Scott L. Rauch, M.D.,
John P. Haran, M.D., Ph.D.,
Alan B. Storrow, M.D.,
Christopher Lewandowski, M.D.,
Paul I. Musey, M.D.,
Phyllis L. Hendry, M.D.,
Sophia Sheikh, M.D.,
Christopher W. Jones, M.D.,
Brittany E. Punches, Ph.D., R.N.,
Robert A. Swor, D.O.,
Meghan E. McGrath, M.D.,
Lauren A. Hudak, M.D., M.P.H.,
Jose L. Pascual, M.D., Ph.D.,
Mark J. Seamon, M.D.,
Elizabeth M. Datner, M.D.,
Anna M Chang, M.D.,
Claire Pearson, M.D.,
Robert M. Domeier, M.D.,
Niels K. Rathlev, M.D.,
Brian J. O’Neil, M.D.,
Paulina Sergot, M.D.,
Leon D. Sanchez, M.D., M.P.H.,
Mark W. Miller, Ph.D.,
Robert H. Pietrzak, Ph.D., M.P.H.,
Jutta Joormann, Ph.D.,
Deanna M. Barch, Ph.D.,
Diego A. Pizzagalli, Ph.D.,
John F. Sheridan, Ph.D.,
Jordan W. Smoller, M.D., Sc.D.,
Beatriz Luna, Ph.D.,
Steven E. Harte, Ph.D.,
James M. Elliott, Ph.D.,
Ronald C. Kessler, Ph.D.,
Karestan C. Koenen, Ph.D.,
Samuel A. McLean, M.D., M.P.H.,
Jennifer S. Stevens, Ph.D.,
Kerry J. Ressler, M.D., Ph.D.

Pages:661–672
Published Online:22 June 2022

https://doi.org/10.1176/appi.ajp.21090911

Abstract
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Preview Abstract

Objective:Dissociation, a disruption or discontinuity in psychological functioning, is often linked with worse psychiatric symptoms; however, the prognostic value of dissociation after trauma is inconsistent. Determining whether trauma-related ...

September 2022

Decoding Shared Versus Divergent Transcriptomic Signatures Across Cortico-Amygdala Circuitry in PTSD and Depressive Disorders

Andrew E. Jaffe, Ph.D.,
Ran Tao, Ph.D.,
Stephanie C. Page, Ph.D.,
Kristen R. Maynard, Ph.D.,
Elizabeth A. Pattie, B.S.,
Claudia V. Nguyen, B.S.,
Amy Deep-Soboslay, M.S.,
Rahul Bharadwaj, Ph.D.,
Keith A. Young, Ph.D.,
Matthew J. Friedman, M.D., Ph.D.,
Douglas E. Williamson, Ph.D.,
Traumatic Stress Brain Research Group,
Joo Heon Shin, Ph.D.,
Thomas M. Hyde, M.D., Ph.D.,
Keri Martinowich, Ph.D.,
Joel E. Kleinman, M.D., Ph.D.

Pages:673–686
Published Online:6 July 2022

https://doi.org/10.1176/appi.ajp.21020162

Abstract
Full text
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Supplement

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Objective:Posttraumatic stress disorder (PTSD) is a debilitating neuropsychiatric disease that is highly comorbid with major depressive disorder (MDD) and bipolar disorder. The overlap in symptoms is hypothesized to stem from partially shared genetics and ...

Letters to the Editor

September 2022

Psychotherapy’s Role for Treatment-Resistant Depression?

Lucie Bartova, M.D., Ph.D.
Gernot Fugger, M.D., Ph.D.
Markus Dold, M.D.
Alexander Kautzky, M.D., Ph.D.
Dan Rujescu, M.D.
Siegfried Kasper, M.D.

Page:687
Published Online:1 September 2022

https://doi.org/10.1176/appi.ajp.20220212

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September 2022

Psychotherapy’s Role for Treatment-Resistant Depression: Reply to Bartova et al.

John C. Markowitz, M.D.
Jesse H. Wright, M.D., Ph.D.
Frenk Peeters, M.D., Ph.D.
Michael E. Thase, M.D.
James H. Kocsis, M.D.
Donna M. Sudak, M.D.

Page:688
Published Online:1 September 2022

https://doi.org/10.1176/appi.ajp.20220212r

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September 2022

Treatments for Depression in Bipolar II Disorder

Suresh Durgam, M.D.,
Richard Chen, Ph.D.,
Joseph R. Calabrese, M.D.,
Gary S. Sachs, M.D.

Pages:688–690
Published Online:1 September 2022

https://doi.org/10.1176/appi.ajp.22010081

First Page
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September 2022

Treatments for Depression in Bipolar II Disorder: Reply to Durgam et al.

Michael Ostacher, M.D., M.P.H.

Page:690
Published Online:1 September 2022

https://doi.org/10.1176/appi.ajp.22010081r

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Residents’ Journal

September 2022

Highlights From the Residents’ Journal: June 2022

Page:691
Published Online:1 September 2022

https://doi.org/10.1176/appi.ajp.22179008

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Other Items Of Interest

September 2022

Correction to Gray et al.

Page:691
Published Online:1 September 2022

https://doi.org/10.1176/appi.ajp.2019.19050560correction

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