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July 01, 2024 | VOL. 181, NO. 7
CURRENT ISSUE
pp.565-686
June 01, 2024 | VOL. 181, NO. 6
pp.461-564
May 01, 2024 | VOL. 181, NO. 5
pp.347-460
April 01, 2024 | VOL. 181, NO. 4
pp.255-346
March 01, 2024 | VOL. 181, NO. 3
pp.171-254
February 01, 2024 | VOL. 181, NO. 2
pp.83-170
January 01, 2024 | VOL. 181, NO. 1
pp.1-82

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American Journal of Psychiatry

Volume 181, Issue 7

July 2024

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Editor’s Note

July 2024

Affective Disorders, Pharmacogenomics, and Psychiatric Illness-Related Cardiometabolic Problems

Ned H. Kalin, M.D.

Pages:565–568
Published Online:1 July 2024

https://doi.org/10.1176/appi.ajp.20240428

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Editorials

July 2024

Using Medical Records to Investigate the Genetics of Treatment-Resistant Depression Across Health Care Systems

Renato Polimanti, Ph.D.

Pages:569–571
Published Online:1 July 2024

https://doi.org/10.1176/appi.ajp.20240377

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July 2024

Integrating Polygenic Scores and Phenotypic Data to Understand Psychiatric Outcomes

Katie Scott, B.Sc.,
Martin Alda, M.D.

Pages:572–574
Published Online:1 July 2024

https://doi.org/10.1176/appi.ajp.20240398

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July 2024

Antidepressants and Bipolar Disorder: The Plot Thickens

Natalie Gottlieb, Ph.D.,
Allan H. Young, F.R.C.Psych

Pages:575–577
Published Online:1 July 2024

https://doi.org/10.1176/appi.ajp.20240411

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July 2024

Mapping the Depressed Brain Under Stress Using Multimodal Neuroimaging

Teddy J. Akiki, M.D.,
Chadi G. Abdallah, M.D.

Pages:578–580
Published Online:1 July 2024

https://doi.org/10.1176/appi.ajp.20240400

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July 2024

Why Psychological Problems Presage Cardiometabolic Health Problems

Benjamin B. Lahey, Ph.D.

Pages:581–583
Published Online:1 July 2024

https://doi.org/10.1176/appi.ajp.20240370

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APA Leadership Addresses

July 2024

2024 Annual Meeting: Presidential Address

Petros Levounis, M.D., M.A.

Pages:584–585
Published Online:1 July 2024

https://doi.org/10.1176/appi.ajp.24181004

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July 2024

2024 Annual Meeting: President-Elect Address

Ramaswamy Viswanathan, M.D., Dr.Med.Sc.

Pages:586–587
Published Online:1 July 2024

https://doi.org/10.1176/appi.ajp.24181005

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July 2024

2024 Annual Meeting: CEO and Medical Director’s Address

Saul Levin, M.D., M.P.A., F.R.C.P.E.

Pages:588–589
Published Online:1 July 2024

https://doi.org/10.1176/appi.ajp.24181007

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July 2024

Petros Levounis, M.D., M.A., 150th APA President, 2023–2024

Katherine G. Kennedy, M.D.

Page:590
Published Online:1 July 2024

https://doi.org/10.1176/appi.ajp.24181006

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Review and Overview

July 2024

Pharmacogenomic Clinical Support Tools for the Treatment of Depression

Matthew L. Baum, M.D., Ph.D.,
Alik S. Widge, M.D., Ph.D.,
Linda L. Carpenter, M.D.,
William M. McDonald, M.D.,
Bruce M. Cohen, M.D., Ph.D.,
Charles B. Nemeroff, M.D., Ph.D.,
On behalf of the American Psychiatric Association (APA) Workgroup on Biomarkers and Novel Treatments

Pages:591–607
Published Online:30 April 2024

https://doi.org/10.1176/appi.ajp.20230657

Abstract
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Objective:In this review, the authors update the 2018 position statement of the American Psychiatric Association Council of Research Workgroup on Biomarkers and Novel Treatments on pharmacogenomic (PGx) tools for treatment selection in depression.Methods:...

Articles

July 2024

Genome-Wide Association Study of Treatment-Resistant Depression: Shared Biology With Metabolic Traits

JooEun Kang, M.D., Ph.D.,
Victor M. Castro, M.S.,
Michael Ripperger, B.E.,
Sanan Venkatesh, B.S.,
David Burstein, Ph.D.,
Richard Karlsson Linnér, Ph.D.,
Daniel B. Rocha, M.M.,
Yirui Hu, Ph.D.,
Drew Wilimitis, B.S.,
Theodore Morley, B.A.,
Lide Han, Ph.D.,
Rachel Youngjung Kim, M.D., Ph.D.,
Yen-Chen Anne Feng, Ph.D.,
Tian Ge, Ph.D.,
Stephan Heckers, M.D.,
Georgios Voloudakis, M.D., Ph.D.,
Christopher Chabris, Ph.D.,
Panos Roussos, M.D., Ph.D.,
Thomas H McCoy, Jr., M.D.,
Colin G. Walsh, M.D.,
Roy H. Perlis, M.D.,
Douglas M. Ruderfer, Ph.D.

Pages:608–619
Published Online:15 May 2024

https://doi.org/10.1176/appi.ajp.20230247

Abstract
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Objective:Treatment-resistant depression (TRD) occurs in roughly one-third of all individuals with major depressive disorder (MDD). Although research has suggested a significant common variant genetic component of liability to TRD, with heritability ...

July 2024

Association of Occupational Dysfunction and Hospital Admissions With Different Polygenic Profiles in Bipolar Disorder

Lina Jonsson, Ph.D.,
Elin Hörbeck, M.D.,
Amedeo Primerano, M.D.,
Jie Song, Ph.D.,
Robert Karlsson, Ph.D.,
Erik Smedler, M.D., Ph.D.,
Katherine Gordon-Smith, Ph.D.,
Lisa Jones, Ph.D.,
Nicholas Craddock, M.D., Ph.D.,
Ian Jones, Ph.D.,
Patrick F. Sullivan, M.D., Ph.D.,
Erik Pålsson, Ph.D.,
Arianna Di Florio, M.D., Ph.D.,
Timea Sparding, Ph.D.,
Mikael Landén, M.D., Ph.D.

Pages:620–629
Published Online:11 June 2024

https://doi.org/10.1176/appi.ajp.20230073

Abstract
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Objective:Many but not all persons with bipolar disorder require hospital care because of severe mood episodes. Likewise, some but not all patients experience long-term occupational dysfunction that extends beyond acute mood episodes. It is not known ...

July 2024

A Nationwide Target Trial Emulation Assessing the Risk of Antidepressant-Induced Mania Among Patients With Bipolar Depression

Christopher Rohde, M.D., Ph.D.,
Søren Dinesen Østergaard, M.D., Ph.D.,
Oskar Hougaard Jefsen, M.D.

Pages:630–638
Published Online:1 July 2024

https://doi.org/10.1176/appi.ajp.20230477

Abstract
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Objective:Antidepressants are commonly used to treat bipolar depression but may increase the risk of mania. The evidence from randomized controlled trials, however, is limited by short treatment durations, providing little evidence for the long-term risk ...

July 2024

Association of Lower Rostral Anterior Cingulate GABA+ and Dysregulated Cortisol Stress Response With Altered Functional Connectivity in Young Adults With Lifetime Depression: A Multimodal Imaging Investigation of Trait and State Effects

Maria Ironside, D.Phil.,
Jessica M. Duda, B.A.,
Amelia D. Moser, M.A.,
Laura M. Holsen, Ph.D.,
Chun S. Zuo, Ph.D.,
Fei Du, Ph.D.,
Sarah Perlo, B.S.,
Christine E. Richards, B.S.,
Xi Chen, Ph.D.,
Lisa D. Nickerson, Ph.D.,
Kaylee E. Null, B.A.,
Shiba M. Esfand, B.A.,
Madeline M. Alexander, Ph.D.,
David J. Crowley, A.L.M.,
Meghan Lauze, B.S.,
Madhusmita Misra, M.D., M.P.H.,
Jill M. Goldstein, Ph.D.,
Diego A. Pizzagalli, Ph.D.

Pages:639–650
Published Online:30 April 2024

https://doi.org/10.1176/appi.ajp.20230382

Abstract
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Objective:Preclinical work suggests that excess glucocorticoids and reduced cortical γ-aminobutyric acid (GABA) may affect sex-dependent differences in brain regions implicated in stress regulation and depressive phenotypes. The authors sought to address ...

July 2024

Associations Between General and Specific Mental Health Conditions in Young Adulthood and Cardiometabolic Complications in Middle Adulthood: A 40-Year Longitudinal Familial Coaggregation Study of 672,823 Swedish Individuals

Cen Chen, Ph.D.,
Zheng Chang, Ph.D.,
Ralf Kuja-Halkola, Ph.D.,
Brian M. D’Onofrio, Ph.D.,
Henrik Larsson, Ph.D.,
Pontus Andell, M.D., Ph.D.,
Paul Lichtenstein, Ph.D.,
Erik Pettersson, Ph.D.

Pages:651–657
Published Online:24 January 2024

https://doi.org/10.1176/appi.ajp.20220951

Abstract
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Objective:Most mental disorders, when examined individually, are associated with an increased risk of cardiometabolic complications. However, these associations might be attributed to a general liability to psychopathology or confounded by unmeasured ...

Letters to the Editor

July 2024

Commentary on Perinatal Mental Health

Nada L. Stotland, M.D., M.P.H.

Page:658
Published Online:1 July 2024

https://doi.org/10.1176/appi.ajp.20231024

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July 2024

The Role of Atypicals With Regard to Weight Gain in Bipolar Disorder Treatment

Jeffrey A. Mattes, M.D.

Page:658
Published Online:1 July 2024

https://doi.org/10.1176/appi.ajp.20240061

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July 2024

The Role of Atypicals With Regard to Weight Gain in Bipolar Disorder Treatment: Response to Mattes

Hemen Najar, M.D.,
Erik Pålsson, Ph.D.,
Mikael Landén, M.D.

Pages:658–659
Published Online:1 July 2024

https://doi.org/10.1176/appi.ajp.20240061r

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APA OFFICIAL ACTIONS

July 2024

Reports to the Membership

Pages:660–686
Published Online:1 July 2024

https://doi.org/10.1176/appi.ajp.24181003

First Page
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