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American Journal of Psychiatry

Volume 178, Issue 10

October 2021

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Editor's Note

October 2021

Depression and Schizophrenia: Sleep, Medical Risk Factors, Biomarkers, and Treatment

Ned H. Kalin, M.D.

Pages:881–884
Published Online:1 October 2021

https://doi.org/10.1176/appi.ajp.2021.21080824

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Editorials

October 2021

Surrogate Markers of Insulin Resistance in Predicting Major Depressive Disorder: Metabolism Metastasizes to the Brain

Roger S. McIntyre, M.D.

Pages:885–887
Published Online:1 October 2021

https://doi.org/10.1176/appi.ajp.2021.21080814

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October 2021

Clozapine, Long-Acting Injectables (and Polypharmacy?) Superior in U.S. and International Registries

Stefan Leucht, M.D.,
Jari Tiihonen, M.D., Ph.D.

Pages:888–889
Published Online:1 October 2021

https://doi.org/10.1176/appi.ajp.2021.21080825

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October 2021

Do the Benefits of Early Intervention Services for Psychosis Generalize and Persist in the Real World?

Tyrone D. Cannon, Ph.D.

Pages:890–892
Published Online:1 October 2021

https://doi.org/10.1176/appi.ajp.2021.21080792

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October 2021

Translational Mechanistic Biomarkers for the 21st Century

Daniel C. Javitt, M.D., Ph.D.

Pages:893–895
Published Online:1 October 2021

https://doi.org/10.1176/appi.ajp.2021.21080812

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Reviews and Overviews

October 2021

The Evolving Nexus of Sleep and Depression

David T. Plante, M.D., Ph.D.

Pages:896–902
Published Online:1 October 2021

https://doi.org/10.1176/appi.ajp.2021.21080821

Abstract
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Sleep disturbances and depression are closely linked and share a bidirectional relationship. These interconnections can inform the pathophysiology underlying each condition. Insomnia is an established and modifiable risk factor for depression, the ...

October 2021

Sleep Abnormalities in Schizophrenia: State of the Art and Next Steps

Fabio Ferrarelli, M.D., Ph.D.

Pages:903–913
Published Online:17 March 2021

https://doi.org/10.1176/appi.ajp.2020.20070968

Abstract
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Sleep disturbances are commonly observed in schizophrenia, including in chronic, early-course, and first-episode patients. This has generated considerable interest, both in clinical and research endeavors, in characterizing the relationship between ...

Articles

October 2021

Incident Major Depressive Disorder Predicted by Three Measures of Insulin Resistance: A Dutch Cohort Study

Kathleen T. Watson, Ph.D.,
Julia F. Simard, Sc.D.,
Victor W. Henderson, M.S., M.D.,
Lexi Nutkiewicz, B.A.,
Femke Lamers, Ph.D.,
Carla Nasca, Ph.D.,
Natalie Rasgon, M.D., Ph.D.,
Brenda W.J.H. Penninx, M.D., Ph.D.

Pages:914–920
Published Online:23 September 2021

https://doi.org/10.1176/appi.ajp.2021.20101479

Abstract
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Objective: Major depressive disorder is the leading cause of disability worldwide. Yet, there remain significant challenges in predicting new cases of major depression and devising strategies to prevent the disorder. An important first step in this ...

October 2021

Lyme Borreliosis and Associations With Mental Disorders and Suicidal Behavior: A Nationwide Danish Cohort Study

Brian A. Fallon, M.D., M.P.H.,
Trine Madsen, Ph.D.,
Annette Erlangsen, Ph.D.,
Michael E. Benros, M.D., Ph.D.

Pages:921–931
Published Online:28 July 2021

https://doi.org/10.1176/appi.ajp.2021.20091347

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Objective: Lyme borreliosis is a tick-borne infectious disease that may confer an increased risk of mental disorders, but previous studies have been hampered by methodological limitations, including small sample sizes. The authors used a nationwide ...

October 2021

Differences in Antipsychotic Treatment Discontinuation Among Veterans With Schizophrenia in the U.S. Department of Veterans Affairs

Mark Weiser, M.D.,
John M. Davis, M.D.,
Clayton H. Brown, Ph.D.,
Eric P. Slade, Ph.D.,
Li Juan Fang, M.S.,
Deborah R. Medoff, Ph.D.,
Robert W. Buchanan, M.D.,
Linda Levi, B.Sc.,
Michael Davidson, M.D.,
Julie Kreyenbuhl, Pharm.D., Ph.D.

Pages:932–940
Published Online:14 July 2021

https://doi.org/10.1176/appi.ajp.2020.20111657

Abstract
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Objective: Effectiveness of antipsychotic drugs is inferred from relatively small randomized clinical trials conducted with carefully selected and monitored participants. This evidence is not necessarily generalizable to individuals treated in daily ...

October 2021

The Danish OPUS Early Intervention Services for First-Episode Psychosis: A Phase 4 Prospective Cohort Study With Comparison of Randomized Trial and Real-World Data

Christine Merrild Posselt, M.Sc.,
Nikolai Albert, Ph.D., M.D.,
Merete Nordentoft, Dr.Med.Sci., M.D.,
Carsten Hjorthøj, Ph.D., M.Sc.

Pages:941–951
Published Online:28 July 2021

https://doi.org/10.1176/appi.ajp.2021.20111596

Abstract
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Objective: The Danish OPUS trial showed significant efficacy of early intervention services for first-episode schizophrenia spectrum disorders compared with standard treatment, leading to implementation of the OPUS intervention in clinical practice. The ...

October 2021

Auditory Oddball Responses Across the Schizophrenia-Bipolar Spectrum and Their Relationship to Cognitive and Clinical Features

David A. Parker, Ph.D.,
Rebekah L. Trotti, M.S.,
Jennifer E. McDowell, Ph.D.,
Sarah K. Keedy, Ph.D.,
S. Kristian Hill, Ph.D.,
Elliot S. Gershon, M.D.,
Elena I. Ivleva, M.D., Ph.D.,
Godfrey D. Pearlson, M.D.,
Matcheri S. Keshavan, M.D.,
Carol A. Tamminga, M.D.,
Brett A. Clementz, Ph.D.

Pages:952–964
Published Online:19 August 2021

https://doi.org/10.1176/appi.ajp.2021.20071043

Abstract
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Objective: Neural activations during auditory oddball tasks may be endophenotypes for psychosis and bipolar disorder. The authors investigated oddball neural deviations that discriminate multiple diagnostic groups across the schizophrenia-bipolar ...

Official Actions

October 2021

APA Council Reports

Pages:965–982
Published Online:1 October 2021

https://doi.org/10.1176/appi.ajp.2021.1781001

Abstract
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At the 2021 virtual Fall Component Meetings of the American Psychiatric Association, the APA councils heard reports from their components. Following are summaries of the activities of the councils and their components.

Residents’ Journal

October 2021

Highlights From the Residents’ Journal: September 2021

Page:983
Published Online:1 October 2021

https://doi.org/10.1176/appi.ajp.2021.1781002

Abstract
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The Residents’ Journal is a quarterly e-publication that serves as a forum for resident physicians and fellows to share ideas and experiences in training, clinical practice, research, and careers.

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