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American Journal of Psychiatry

Volume 172, Issue 4

April 2015

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Editorials

April 2015

In Treating Alcohol Use Disorders, Why Not Use Evidence-Based Treatment?

Charles O’Brien, M.D., Ph.D.

Pages:305–306
Published Online:31 March 2015

https://doi.org/10.1176/appi.ajp.2014.14111413

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April 2015

C-Reactive Protein: A Stress Diathesis Marker at the Crossroads of Maladaptive Behavioral and Cardiometabolic Sequelae

Ronen H. Segman, M.D.,
Murray B. Stein, M.D., M.P.H.

Pages:307–309
Published Online:31 March 2015

https://doi.org/10.1176/appi.ajp.2015.15010063

First Page
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April 2015

Electronic Medical Records: Fast Track to Big Data in Bipolar Disorder

James B. Potash, M.D., M.P.H.

Pages:310–311
Published Online:31 March 2015

https://doi.org/10.1176/appi.ajp.2015.15010043

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April 2015

Evidence for Schizophrenia as a Disorder of Neuroplasticity

Robert E. McCullumsmith, M.D.

Pages:312–313
Published Online:31 March 2015

https://doi.org/10.1176/appi.ajp.2015.15010069

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Commentary

April 2015

Reporting on China’s Mental Health Surveillance

Wei Zhou, M.A.,
Shuiyuan Xiao, M.D.

Pages:314–315
Published Online:31 March 2015

https://doi.org/10.1176/appi.ajp.2015.14070945

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Education in Psychiatry

April 2015

A Clinical Perspective on the Relevance of Research Domain Criteria in Electronic Health Records

Thomas H. McCoy, M.D.,
Victor M. Castro, M.S.,
Hannah R. Rosenfield, B.A.,
Andrew Cagan, B.S.,
Isaac S. Kohane, M.D.,
Roy H. Perlis, M.D., M.Sc.

Pages:316–320
Published Online:31 March 2015

https://doi.org/10.1176/appi.ajp.2014.14091177

Abstract
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Objective:The limitations of the DSM nosology for capturing dimensionality and overlap in psychiatric syndromes, and its poor correspondence to underlying neurobiology, have been well established. The Research Domain Criteria (RDoC), a proposed ...

Images in Psychiatry

April 2015

Charles Darwin and the Asylum Letters

Malcolm King, M.S., R.N.

Pages:321–322
Published Online:31 March 2015

https://doi.org/10.1176/appi.ajp.2014.14101260

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Reviews and Overviews

April 2015

Modifiable Predictors of Dementia in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis

Claudia Cooper, Ph.D., M.R.C.Psych.,
Andrew Sommerlad, M.R.C.Psych.,
Constantine G. Lyketsos, M.D., M.H.S.,
Gill Livingston M.D., F.R.C.Psych.

Pages:323–334
Published Online:20 February 2015

https://doi.org/10.1176/appi.ajp.2014.14070878

Abstract
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Objective:Public health campaigns encouraging early help seeking have increased rates of mild cognitive impairment (MCI) diagnosis in Western countries, but we know little about how to treat or predict dementia outcomes in persons with the condition....

Articles

April 2015

Effects of Cognitive Bias Modification Training on Neural Alcohol Cue Reactivity in Alcohol Dependence

Corinde E. Wiers, Ph.D.,
Christine Stelzel, Ph.D.,
Thomas E. Gladwin, Ph.D.,
Soyoung Q. Park, Ph.D.,
Steffen Pawelczack, M.Sc.,
Christiane K. Gawron, Cand.med.,
Heiner Stuke, M.D.,
Andreas Heinz, M.D., Ph.D.,
Reinout W. Wiers, Ph.D.,
Mike Rinck, Ph.D.,
Johannes Lindenmeyer, Ph.D.,
Henrik Walter, M.D., Ph.D.,
Felix Bermpohl, M.D., Ph.D.

Pages:335–343
Published Online:19 December 2014

https://doi.org/10.1176/appi.ajp.2014.13111495

Abstract
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Objective:In alcohol-dependent patients, alcohol cues evoke increased activation in mesolimbic brain areas, such as the nucleus accumbens and the amygdala. Moreover, patients show an alcohol approach bias, a tendency to more quickly approach than avoid ...

April 2015

Pragmatic Replication Trial of Health Promotion Coaching for Obesity in Serious Mental Illness and Maintenance of Outcomes

Stephen J. Bartels, M.D., M.S.,
Sarah I. Pratt, Ph.D.,
Kelly A. Aschbrenner, Ph.D.,
Laura K. Barre, M.D.,
John A. Naslund, M.P.H.,
Rosemarie Wolfe, M.S.,
Haiyi Xie, Ph.D.,
Gregory J. McHugo, Ph.D.,
Daniel E. Jimenez, Ph.D.,
Ken Jue, M.S.S.A.,
James Feldman, M.D., M.P.H.,
Bruce L. Bird, Ph.D.

Pages:344–352
Published Online:12 December 2014

https://doi.org/10.1176/appi.ajp.2014.14030357

Abstract
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Objective:Few studies targeting obesity in serious mental illness have reported clinically significant risk reduction, and none have been replicated in community settings or demonstrated sustained outcomes after intervention withdrawal. The authors sought ...

April 2015

Association of CRP Genetic Variation and CRP Level With Elevated PTSD Symptoms and Physiological Responses in a Civilian Population With High Levels of Trauma

Vasiliki Michopoulos, Ph.D.,
Alex O. Rothbaum, B.S.,
Tanja Jovanovic, Ph.D.,
Lynn M. Almli, Ph.D.,
Bekh Bradley, Ph.D.,
Barbara O. Rothbaum, Ph.D.,
Charles F. Gillespie, M.D., Ph.D.,
Kerry J. Ressler, M.D., Ph.D.

Pages:353–362
Published Online:12 December 2014

https://doi.org/10.1176/appi.ajp.2014.14020263

Abstract
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Objective:Increased systemic inflammation is associated with stress-related psychopathology. Specifically, levels of the proinflammatory marker C-reactive protein (CRP) are elevated in individuals with posttraumatic stress disorder (PTSD). Furthermore, ...

April 2015

Validation of Electronic Health Record Phenotyping of Bipolar Disorder Cases and Controls

Victor M. Castro, M.S.,
Jessica Minnier, Ph.D.,
Shawn N. Murphy, M.D., Ph.D.,
Isaac Kohane, M.D., Ph.D.,
Susanne E. Churchill, Ph.D.,
Vivian Gainer, M.S.,
Tianxi Cai, Sc.D.,
Alison G. Hoffnagle, M.S.,
Yael Dai, B.A.,
Stefanie Block, M.S.,
Sydney R. Weill, B.A.,
Mireya Nadal-Vicens, M.D., Ph.D.,
Alisha R. Pollastri, Ph.D.,
J. Niels Rosenquist, M.D., Ph.D.,
Sergey Goryachev, M.S.,
Dost Ongur, M.D., Ph.D.,
Pamela Sklar, M.D., Ph.D.,
Roy H. Perlis, M.D., M.Sc.,
Jordan W. Smoller, M.D., Sc.D.,
for the International Cohort Collection for Bipolar Disorder Consortium,

Pages:363–372
Published Online:12 December 2014

https://doi.org/10.1176/appi.ajp.2014.14030423

Abstract
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Objective:The study was designed to validate use of electronic health records (EHRs) for diagnosing bipolar disorder and classifying control subjects.Method:EHR data were obtained from a health care system of more than 4.6 million patients spanning more ...

April 2015

Synaptic Proteins in the Hippocampus Indicative of Increased Neuronal Activity in CA3 in Schizophrenia

Wei Li, M.D.,
Subroto Ghose, M.D.,
Kelly Gleason, M.S.,
Anita Begovic, M.D.,
Jessica Perez, M.S.,
John Bartko, Ph.D.,
Scott Russo, Ph.D.,
Anthony D. Wagner, Ph.D.,
Lynn Selemon, Ph.D.,
Carol A. Tamminga, M.D.

Pages:373–382
Published Online:13 January 2015

https://doi.org/10.1176/appi.ajp.2014.14010123

Abstract
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Objective:In schizophrenia, hippocampal perfusion is increased and declarative memory function is degraded. Based on an a priori model of hippocampal dysfunction in schizophrenic psychosis, the authors postulated molecular and cellular changes in CA3 ...

April 2015

Reward-Based Spatial Learning in Unmedicated Adults With Obsessive-Compulsive Disorder

Rachel Marsh, Ph.D.,
Gregory Z. Tau, M.D., Ph.D.,
Zhishun Wang, Ph.D.,
Yuankai Huo, M.S.,
Ge Liu, M.S.,
Xuejun Hao, Ph.D.,
Mark G. Packard, Ph.D.,
Bradley S. Peterson, M.D.,
H. Blair Simpson, M.D., Ph.D.,

Pages:383–392
Published Online:19 December 2014

https://doi.org/10.1176/appi.ajp.2014.13121700

Abstract
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Objective:The authors assessed the functioning of mesolimbic and striatal areas involved in reward-based spatial learning in unmedicated adults with obsessive-compulsive disorder (OCD).Method:Functional MRI blood-oxygen-level-dependent response was ...

Letters to the Editor

April 2015

Treatments for Social Anxiety Disorder: Considerations Regarding Psychodynamic Therapy Findings

Stefan G. Hofmann, Ph.D.,
David H. Barlow, Ph.D.,
David M. Clark, D.Phil.,
Steven D. Hollon, Ph.D.,
Evan Mayo-Wilson, D.Phil.

Page:393
Published Online:31 March 2015

https://doi.org/10.1176/appi.ajp.2015.14101347

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April 2015

Response to Hofmann et al.

Falk Leichsenring, D.Sc.,
Simone Salzer, D.Sc.,
Eric Leibing, D.Sc.

Pages:393–394
Published Online:31 March 2015

https://doi.org/10.1176/appi.ajp.2015.14101347r

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April 2015

Sex Difference in Response to Varenicline for Smoking Cessation

David A. Gorelick, M.D., Ph.D., D.L.F.A.P.A.

Pages:394–395
Published Online:31 March 2015

https://doi.org/10.1176/appi.ajp.2015.14111429

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April 2015

Response to Gorelick

Jed E. Rose, Ph.D.,
Frédérique M. Behm, C.R.A.

Page:395
Published Online:31 March 2015

https://doi.org/10.1176/appi.ajp.2015.14111429r

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April 2015

Association of a Brain Methylation Site With Clinical Outcomes in Depression Does Not Replicate Across Populations

Rudolf Uher, M.D., Ph.D.,
Stephan Ripke, M.D., Ph.D.,
Bertram Müller-Myhsok, M.D.,
Cathryn M. Lewis, Ph.D.,
Roy H. Perlis, M.D.

Pages:395–397
Published Online:31 March 2015

https://doi.org/10.1176/appi.ajp.2015.14101348

First Page
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April 2015

Response to Uher et al.

Ma-Li Wong, M.D.,
Chuanhui Dong Ph.D.,
Deborah L. Flores, M.D.,
Monika Ehrhart-Bornstein, Ph.D.,
Stefan Bornstein, M.D., Ph.D.,
Mauricio Arcos-Burgos, M.D., Ph.D.,
Julio Licinio, M.D.

Pages:396–398
Published Online:31 March 2015

https://doi.org/10.1176/appi.ajp.2015.14101348r

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Disclosure of Editors’ Financial Relationships

April 2015

Disclosure of Editors’ Financial Relationships

Page:398
Published Online:1 April 2015

https://doi.org/10.1176/appi.ajp.2015.1724disclosure

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