The American Psychiatric Association (APA) has updated its Privacy Policy and Terms of Use, including with new information specifically addressed to individuals in the European Economic Area. As described in the Privacy Policy and Terms of Use, this website utilizes cookies, including for the purpose of offering an optimal online experience and services tailored to your preferences.

Please read the entire Privacy Policy and Terms of Use. By closing this message, browsing this website, continuing the navigation, or otherwise continuing to use the APA's websites, you confirm that you understand and accept the terms of the Privacy Policy and Terms of Use, including the utilization of cookies.

Communications and UpdatesFull Access

Response to Gorelick

To the Editor: Dr. Gorelick raises a reasonable question as to whether the sex-by-treatment interaction reported in our article on combined varenicline/bupropion sustained-release treatment could have been due in part to a lower efficacy of varenicline alone in men compared with women. Although we, along with the editorialist, highlight this possibility, two factors argue against it being a major contributor to the interaction effect. First, the previous literature has not reported sex differences in varenicline treatment. Second, the statistical argument advanced in Dr. Gorelick's comment is imprecise. Error-bar overlap is not a reliable criterion for assessing statistical significance. Using the information presented in Table 2 of our article, a chi-square calculation yields a p value of 0.27 for the difference between varenicline plus placebo treatment in men compared with women. Thus, although the possibility remains that there is an effect that contributed to the overall interaction effect, there is no compelling data in support of that interpretation at the present time.

From the Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N.C.

The authors’ disclosures accompany the original article.