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American Journal of Psychiatry

Volume 167, Issue 12

December 2010

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In This Issue

December 2010

Page:A30
Published Online:1 December 2010

https://doi.org/10.1176/appi.ajp.2010.167.12.a30

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Editorials

December 2010

The Changing Face of U.S. Mental Health Care

Benjamin G. Druss, M.D., M.P.H.

Pages:1419–1421
Published Online:1 December 2010

https://doi.org/10.1176/appi.ajp.2010.10091258

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December 2010

Beyond Sticks and Stones

Frank W. Putnam, M.D.

Pages:1422–1424
Published Online:1 December 2010

https://doi.org/10.1176/appi.ajp.2010.10091323

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December 2010

Probing the Genome to Understand Suicide

Rudolf Uher, M.D., PH.D., and
Nader Perroud, M.D.

Pages:1425–1427
Published Online:1 December 2010

https://doi.org/10.1176/appi.ajp.2010.10081227

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December 2010

Early Prevention in Childhood Anxiety Disorders

Bruce Cuthbert, PH.D.

Pages:1428–1430
Published Online:1 December 2010

https://doi.org/10.1176/appi.ajp.2010.10091316

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December 2010

Robert Freedman, M.D.,
David A. Lewis, M.D.,
Robert Michels, M.D.,
Daniel S. Pine, M.D.,
Susan K. Schultz, M.D., and
Carol A. Tamminga, M.D.

Pages:1431–1434
Published Online:1 December 2010

https://doi.org/10.1176/appi.ajp.2010.10091371

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Introspection

December 2010

Bloodletting 1854

Marshall L. Garrick, M.D.

Pages:1435–1436
Published Online:1 December 2010

https://doi.org/10.1176/appi.ajp.2010.10081126

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Clinical Case Conference

December 2010

Deep Brain Stimulation for Treatment-Resistant Depression

Paul E. Holtzheimer, M.D., and
Helen S. Mayberg, M.D.

Pages:1437–1444
Published Online:1 December 2010

https://doi.org/10.1176/appi.ajp.2010.10010141

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Reviews and Overviews

December 2010

Personalized Medicine for Depression: Can We Match Patients With Treatments?

Gregory E. Simon, M.D., M.P.H., and
Roy H. Perlis, M.D., M.Sc.

Pages:1445–1455
Published Online:1 December 2010

https://doi.org/10.1176/appi.ajp.2010.09111680

Abstract
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Objective:Response to specific depression treatments varies widely among individuals. Understanding and predicting that variation could have great benefits for people living with depression. Method:The authors describe a conceptual model for identifying ...

Articles

December 2010

National Trends in Outpatient Psychotherapy

Mark Olfson, M.D., M.P.H., and
Steven C. Marcus, Ph.D.

Pages:1456–1463
Published Online:1 December 2010

https://doi.org/10.1176/appi.ajp.2010.10040570

Abstract
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Objective:The authors investigated recent trends in the use of outpatient psychotherapy in the United States. Method:Service use data from two representative surveys of the U.S. general population, the 1998 (N=22,953) and 2007 (N=29,370) Medical ...

December 2010

Hurtful Words: Association of Exposure to Peer Verbal Abuse With Elevated Psychiatric Symptom Scores and Corpus Callosum Abnormalities

Martin H. Teicher, M.D., Ph.D.,
Jacqueline A. Samson, Ph.D.,
Yi-Shin Sheu, M.A.,
Ann Polcari, R.N., Ph.D., and
Cynthia E. McGreenery

Pages:1464–1471
Published Online:1 December 2010

https://doi.org/10.1176/appi.ajp.2010.10010030

Abstract
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Objective:Previous studies have shown that exposure to parental verbal abuse in childhood is associated with higher rates of adult psychopathology and alterations in brain structure. In this study the authors sought to examine the symptomatic and ...

December 2010

Agreement Between Clinician and Patient Ratings of Adaptive Functioning and Developmental History

Jared A. DeFife, Ph.D.,
Rebecca Drill, Ph.D.,
Ora Nakash, Ph.D., and
Drew Westen, Ph.D.

Pages:1472–1478
Published Online:1 December 2010

https://doi.org/10.1176/appi.ajp.2010.09101489

Abstract
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Objective:Psychiatric researchers rely heavily on patient report data for clinical research. However, patient reports are prone to defensive and self-presentation biases. Recent research using practice networks has relied on clinician reports, and both ...

December 2010

Expression of Interneuron Markers in the Dorsolateral Prefrontal Cortex of the Developing Human and in Schizophrenia

Samantha J. Fung, Ph.D.,
Maree J. Webster, Ph.D.,
Sinthuja Sivagnanasundaram, Ph.D.,
Carlotta Duncan, Ph.D.,
Michael Elashoff, Ph.D., and
Cynthia Shannon Weickert, Ph.D.

Pages:1479–1488
Published Online:1 December 2010

https://doi.org/10.1176/appi.ajp.2010.09060784

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Objective:The onset of schizophrenia symptoms in late adolescence implies a neurodevelopmental trajectory for the disease. Indeed, the γ-aminobutyric acid (GABA) inhibitory system shows protracted development, and GABA-ergic deficits are widely replicated ...

December 2010

Alterations in Metabotropic Glutamate Receptor 1α and Regulator of G Protein Signaling 4 in the Prefrontal Cortex in Schizophrenia

David W. Volk, M.D., Ph.D.,
Stephen M. Eggan, Ph.D., and
David A. Lewis, M.D.

Pages:1489–1498
Published Online:1 December 2010

https://doi.org/10.1176/appi.ajp.2010.10030318

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Objective:Certain cognitive deficits in individuals with schizophrenia have been linked to disturbed gamma-aminobutyric acid (GABA) and glutamate neurotrans-mission in the prefrontal cortex. Thus, it is important to understand how the mechanisms that ...

December 2010

Genome-Wide Association Study of Suicide Attempts in Mood Disorder Patients

Roy H. Perlis, M.D., M.Sc.,
Jie Huang, M.D., M.S., M.P.H. ,
Shaun Purcell, Ph.D. ,
Maurizio Fava, M.D.,
A. John Rush, M.D.,
Patrick F. Sullivan, M.D. ,
Steven P. Hamilton, M.D., Ph.D. ,
Francis J. McMahon, M.D. ,
Thomas Schulze, M.D.,
James B. Potash, M.D., M.P.H. ,
Peter P. Zandi, Ph.D.,
Virginia L. Willour, Ph.D. ,
Brenda W. Penninx, Ph.D., M.D. ,
Dorret I. Boomsma, Ph.D. ,
Nicole Vogelzangs, Ph.D. ,
Christel M. Middeldorp, M.D., Ph.D.,
Marcella Rietschel, M.D.,
Markus Nöthen, Ph.D.,
Sven Cichon, Ph.D.,
Hugh Gurling, M.D., M.Phil. ,
Nick Bass, M.D.,
Andrew McQuillin, Ph.D. ,
Marian Hamshere, Ph.D. ,
Wellcome Trust Case Control Consortium Bipolar Disorder Group,
Nick Craddock, M.D., Ph.D. ,
Pamela Sklar, M.D., Ph.D. , and
Jordan W. Smoller, M.D., Sc.D.

Pages:1499–1507
Published Online:1 December 2010

https://doi.org/10.1176/appi.ajp.2010.10040541

Abstract
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Objective:Family and twin studies suggest that liability for suicide attempts is heritable and distinct from mood disorder susceptibility. The authors therefore examined the association between common genomewide variation and lifetime suicide attempts. ...

December 2010

Association of Mouse Dlg4 (PSD-95) Gene Deletion and Human DLG4 Gene Variation With Phenotypes Relevant to Autism Spectrum Disorders and Williams' Syndrome

Michael Feyder, B.S.,
Rose-Marie Karlsson, Ph.D.,
Poonam Mathur, B.S.,
Matthew Lyman, B.S.,
Roland Bock, M.Sc.,
Reza Momenan, Ph.D.,
Jeeva Munasinghe, Ph.D.,
Maria Luisa Scattoni, Ph.D.,
Jessica Ihne, B.S.,
Marguerite Camp, Ph.D.,
Carolyn Graybeal, B.A.,
Douglas Strathdee, Ph.D.,
Alison Begg, Ph.D.,
Veronica A. Alvarez, Ph.D.,
Peter Kirsch, Ph.D.,
Marcella Rietschel, M.D.,
Sven Cichon, Ph.D.,
Henrik Walter, M.D., Ph.D.,
Andreas Meyer-Lindenberg, M.D., Ph.D.,
Seth G.N. Grant, B.Sc., M.B.B.S., and
Andrew Holmes, Ph.D.

Pages:1508–1517
Published Online:1 December 2010

https://doi.org/10.1176/appi.ajp.2010.10040484

Abstract
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Objective:Research is increasingly linking autism spectrum disorders and other neurodevelopmental disorders to synaptic abnormalities (“synaptopathies”). PSD-95 (postsynaptic density-95, DLG4) orchestrates protein-protein interactions at excitatory ...

December 2010

Altering the Trajectory of Anxiety in At-Risk Young Children

Ronald M. Rapee, Ph.D.,
Susan J. Kennedy, Ph.D.,
Michelle Ingram, M.Clin.Psych.,
Susan L. Edwards, Ph.D., and
Lynne Sweeney, Ph.D.

Pages:1518–1525
Published Online:1 December 2010

https://doi.org/10.1176/appi.ajp.2010.09111619

Abstract
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Objective:Increasing evidence for the importance of several risk factors for anxiety disorders is beginning to point to the possibility of prevention. Early interventions targeting known risk for anxiety have rarely been evaluated. The authors evaluated ...

December 2010

Social Norm Processing in Adult Social Phobia: Atypically Increased Ventromedial Frontal Cortex Responsiveness to Unintentional (Embarrassing) Transgressions

Karina S. Blair, Ph.D.,
Marilla Geraci, M.S.N.,
Nick Hollon, B.A.,
Marcela Otero, B.A.,
Jeffrey DeVido, M.D.,
Catherine Majestic, B.A.,
Madeline Jacobs,
R.J.R. Blair, Ph.D., and
Daniel S. Pine, M.D.

Pages:1526–1532
Published Online:1 December 2010

https://doi.org/10.1176/appi.ajp.2010.09121797

Abstract
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Objective:Little is known about the neural underpinnings of generalized social phobia, which is defined by a persistent heightened fear of social disapproval. Using event-related functional MRI (fMRI), the authors examined whether the intent of an event, ...

Letters to the Editor

December 2010

Risperidone-Associated Hypocalcemia

Dragan R. Milovanovic, M.D., Ph.D.,
Vladimir Janjic, M.D., M.Sc.,
Nenad Zornic, M.D., M.Sc.,
Slavica Djukic Dejanovic, M.D., Ph.D., and
Slobodan M. Jankovic, M.D., Ph.D.

Pages:1533–1534
Published Online:1 December 2010

https://doi.org/10.1176/appi.ajp.2010.10071003

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December 2010

Discrepancy in Response and Remission Rates for SAMe-Treated Patients in a Double-Blind, Randomized Clinical Trial

Sheryl B. Fleisch, M.D.,
Michael J. Travis, M.D., and
Neil D. Ryan, M.D.

Page:1533
Published Online:1 December 2010

https://doi.org/10.1176/appi.ajp.2010.10091252

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December 2010

Reply to Fleisch et al. Letter

George I. Papakostas, M.D.

Page:1533
Published Online:1 December 2010

https://doi.org/10.1176/appi.ajp.2010.10091252r

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December 2010

Melancholia as a Distinct Mood Disorder? Recommendations for DSM-5

James H. Kocsis, M.D.

Page:1534
Published Online:1 December 2010

https://doi.org/10.1176/appi.ajp.2010.10070983

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December 2010

New-Onset Psychosis and Emergence of Suicidal Ideation With Aripiprazole

Vithyalakshmi Selvaraj, M.D.,
Sriram Ramaswamy, M.D.,
Ashish Sharma, M.D., and
Daniel Wilson, M.D.

Pages:1535–1536
Published Online:1 December 2010

https://doi.org/10.1176/appi.ajp.2010.10020238

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December 2010

Reply to Kocsis Letter

Gordon Parker, M.D.,
Max Fink, M.D.,
Edward Shorter, Ph.D.,
Michael Alan Taylor, M.D.,
Hagop Akiskal, M.D.,
German Berrios, M.D.,
Tom Bolwig, M.D.,
Walter A. Brown, M.D.,
Bernard Carroll, M.B.B.S.,
David Healy, M.D.,
Donald F. Klein, M.D.,
Athanasios Koukopoulos, M.D.,
Robert Michels, M.D.,
Joel Paris, M.D.,
Robert T. Rubin, M.D.,
Robert Spitzer, M.D., and
Conrad Swartz, M.D.

Page:1535
Published Online:1 December 2010

https://doi.org/10.1176/appi.ajp.2010.10091297

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Book Forum

December 2010

Diana Martin, M.D.

Pages:1537–1538
Published Online:1 December 2010

https://doi.org/10.1176/appi.ajp.2010.10081226

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December 2010

Every Man Dies Alone/Berlin at War: Life and Death in Hitler's Capital. 1939–45

Judith Freedman, M.D., F.R.C.Psych.

Pages:1538–1539
Published Online:1 December 2010

https://doi.org/10.1176/appi.ajp.2010.10091243

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December 2010

Asylum: Inside the Closed World of State Mental Hospitals

Joel Yager, M.D.

Page:1539
Published Online:1 December 2010

https://doi.org/10.1176/appi.ajp.2010.10091262

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December 2010

Wolf Hall: A Novel

Peter J. Buckley, M.D.

Pages:1540–1541
Published Online:1 December 2010

https://doi.org/10.1176/appi.ajp.2010.10070950

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December 2010

The Rest Is Noise: Listening to the Twentieth Century

John Lawrence, B.A.(Hons.)

Page:1540
Published Online:1 December 2010

https://doi.org/10.1176/appi.ajp.2010.10091249

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Books Received

December 2010

Page:1542
Published Online:1 December 2010

https://doi.org/10.1176/appi.ajp.2010.167.12.1542

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