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American Journal of Psychiatry

Volume 167, Issue 7

July 2010

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In This Issue

July 2010

Page:A14
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2010.167.7.a14

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Editorial

July 2010

Rethinking the Role of Mental Illness in Suicide

Michael R. Phillips, M.D., M.P.H.

Pages:731–733
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2010.10040589

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July 2010

Treatment of Depressed Adolescents

John T. Walkup, M.D.

Pages:734–737
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2010.10040566

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July 2010

Is There a Role for Antidepressants in the Treatment of Bipolar II Depression?

Trisha Suppes, M.D., Ph.D.

Pages:738–740
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2010.10040590

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July 2010

Genome-Wide Association Studies: Does Only Size Matter?

Sharon Schwartz, Ph.D., and
Ezra Susser, M.D., Dr.P.H.

Pages:741–744
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2010.10030465

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July 2010

Issues for DSM-5: Whither Melancholia? The Case for Its Classification as a Distinct Mood Disorder

Gordon Parker, M.D.,
Max Fink, M.D.,
Edward Shorter, Ph.D.,
Michael Alan Taylor, M.D.,
Hagop Akiskal, M.D.,
German Berrios, M.D.,
Tom Bolwig, M.D.,
Walter A. Brown, M.D.,
Bernard Carroll, M.B.B.S.,
David Healy, M.D.,
Donald F. Klein, M.D.,
Athanasios Koukopoulos, M.D.,
Robert Michels, M.D.,
Joel Paris, M.D.,
Robert T. Rubin, M.D.,
Robert Spitzer, M.D., and
Conrad Swartz, M.D.

Pages:745–747
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2010.09101525

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Commentary

July 2010

Research Domain Criteria (RDoC): Toward a New Classification Framework for Research on Mental Disorders

Thomas Insel, M.D.,
Bruce Cuthbert, Ph.D.,
Marjorie Garvey, M.B., B.CH.,
Robert Heinssen, Ph.D.,
Daniel S. Pine, M.D.,
Kevin Quinn, Ph.D.,
Charles Sanislow, Ph.D., and
Philip Wang, M.D., DR.P.H.

Pages:748–751
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2010.09091379

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Introspections

July 2010

Paul C. Holinger, M.D., M.P.H.

Pages:752–753
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2010.10020288

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Clinical Case Conference

July 2010

Diagnosis and Treatment of a Patient With Both Psychotic and Obsessive-Compulsive Symptoms

Carolyn I. Rodriguez, M.D., Ph.D.,
Cheryl Corcoran, M.D., and
Helen Blair Simpson, M.D., Ph.D.

Pages:754–761
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2009.09070997

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Images in Psychiatry

July 2010

Hargeisa Group Hospital Psychiatric Ward

Lorin Boynton, M.D.,
Jacob Bentley, M.A.,
Nimo Hussein, B.S.N., and
J. Carey Jackson, M.D., M.P.H., M.A.

Page:762
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2010.10030299

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Reviews and Overviews

July 2010

D₂ Receptor Genetic Variation and Clinical Response to Antipsychotic Drug Treatment: A Meta-Analysis

Jian-Ping Zhang, M.D., Ph.D.,
Todd Lencz, Ph.D., and
Anil K. Malhotra, M.D.

Pages:763–772
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2009.09040598

Abstract
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ObjectiveSeveral lines of evidence suggest that antipsychotic drug efficacy is mediated by dopamine type 2 (D₂) receptor blockade. Therefore, it seems plausible that variation in the DRD₂ gene is associated with clinical response to antipsychotic drug ...

Article

July 2010

Mental Disorders and Suicide Among Young Rural Chinese: A Case-Control Psychological Autopsy Study

Jie Zhang, Ph.D.,
Shuiyuan Xiao, M.D., Ph.D., and
Liang Zhou, M.D., Ph.D.

Pages:773–781
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2010.09101476

Abstract
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ObjectiveThe authors examined the prevalence and distribution of mental disorders in rural Chinese 15–34 years of age who committed suicide. They hypothesized that mental illness is a risk factor for suicide in this population and that the prevalence of ...

July 2010

Treatment of Resistant Depression in Adolescents (TORDIA): Week 24 Outcomes

Graham J. Emslie, M.D.,
Taryn Mayes, M.S.,
Giovanna Porta, M.S.,
Benedetto Vitiello, M.D.,
Greg Clarke, Ph.D.,
Karen Dineen Wagner, M.D., Ph.D.,
Joan Rosenbaum Asarnow, Ph.D.,
Anthony Spirito, Ph.D.,
Boris Birmaher, M.D.,
Neal Ryan, M.D.,
Betsy Kennard, Psy.D.,
Lynn DeBar, Ph.D.,
James McCracken, M.D.,
Michael Strober, Ph.D.,
Matthew Onorato, L.C.S.W.,
Jamie Zelazny, M.P.H., R.N.,
Marty Keller, M.D.,
Satish Iyengar, Ph.D., and
David Brent, M.D.

Pages:782–791
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2010.09040552

Abstract
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ObjectiveThe purpose of this study was to report on the outcome of participants in the Treatment of Resistant Depression in Adolescents (TORDIA) trial after 24 weeks of treatment, including remission and relapse rates and predictors of treatment outcome. ...

July 2010

Efficacy and Safety of Long-Term Fluoxetine Versus Lithium Monotherapy of Bipolar II Disorder: A Randomized, Double-Blind, Placebo-Substitution Study

Jay D. Amsterdam, M.D., and
Justine Shults, Ph.D.

Pages:792–800
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2009.09020284

Abstract
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ObjectiveThe authors examined the safety and efficacy of long-term fluoxetine monotherapy, lithium monotherapy, and placebo therapy in preventing relapse and recurrence of bipolar type II major depressive episode. The authors hypothesized that fluoxetine ...

July 2010

Incidence and Predictors of Suicide Attempts in DSM–IV Major Depressive Disorder: A Five-Year Prospective Study

K. Mikael Holma, M.D.,
Tarja K. Melartin, M.D., Ph.D.,
Jari Haukka, Ph.D.,
Irina A.K. Holma, M.D.,
T. Petteri Sokero, M.D., Ph.D., and
Erkki T. Isometsä, M.D., Ph.D.

Pages:801–808
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2010.09050627

Abstract
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ObjectiveProspective long-term studies of risk factors for suicide attempts among patients with major depressive disorder have not investigated the course of illness and state at the time of the act. Therefore, the importance of state factors, ...

July 2010

Association of Autistic-Like and Internalizing Traits During Childhood: A Longitudinal Twin Study

Victoria Hallett, M.Sc.,
Angelica Ronald, Ph.D.,
Fruhling Rijsdijk, Ph.D., and
Francesca Happé, Ph.D.

Pages:809–817
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2009.09070990

Abstract
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ObjectiveChildren with autism spectrum disorders often experience severe anxiety and depression, yet the explanation for this association remains unclear. The authors examined the longitudinal relationship between autistic-like and internalizing traits ...

July 2010

Sensory Deficits and Distributed Hierarchical Dysfunction in Schizophrenia

David I. Leitman, Ph.D.,
Pejman Sehatpour, M.D., Ph.D.,
Beth A. Higgins, B.S.,
John J. Foxe, Ph.D.,
Gail Silipo, M.A., and
Daniel C. Javitt, M.D., Ph.D.

Pages:818–827
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2010.09030338

Abstract
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ObjectiveSchizophrenia is characterized by widespread cognitive deficits that reflect distributed dysfunction across multiple cortical regions. Here the authors examined the relationship between lower- and higher-level dysfunction within the auditory ...

July 2010

Processing Speed Deficits in Schizophrenia: Reexamining the Evidence

Emma E.M. Knowles, M.Sc.,
Anthony S. David, M.D., F.R.C.Psych., and
Abraham Reichenberg, Ph.D.

Pages:828–835
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2010.09070937

Abstract
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ObjectiveA recent meta-analysis identified processing speed inefficiency as the largest single cognitive impairment in schizophrenia. However, the effect of potential moderator variables, such as medication status and severity of illness, remained ...

July 2010

Abnormal Hippocampal Functioning and Impaired Spatial Navigation in Depressed Individuals: Evidence From Whole-Head Magnetoencephalography

Brian R. Cornwell, Ph.D.,
Giacomo Salvadore, M.D.,
Veronica Colon-Rosario, B.A.,
David R. Latov, B.A.,
Tom Holroyd, Ph.D.,
Frederick W. Carver, Ph.D.,
Richard Coppola, Ph.D.,
Husseini K. Manji, M.D.,
Carlos A. Zarate, M.D., and
Christian Grillon, Ph.D.

Pages:836–844
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2009.09050614

Abstract
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ObjectiveDysfunction of the hippocampus has long been suspected to be a key component of the pathophysiology of major depressive disorder. Despite evidence of hippocampal structural abnormalities in depressed patients, abnormal hippocampal functioning has ...

July 2010

Performance-Based Measures of Everyday Function in Mild Cognitive Impairment

Terry E. Goldberg, Ph.D.,
Jeremy Koppel, M.D.,
Lynda Keehlisen, M.A.,
Erica Christen, B.S.,
Ute Dreses-Werringloer, Ph.D.,
Concepcion Conejero-Goldberg, M.D., Ph.D.,
Marc L. Gordon, M.D., and
Peter Davies, Ph.D.

Pages:845–853
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2010.09050692

Abstract
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ObjectiveThe view that everyday function is preserved in mild cognitive impairment may be problematic. The objectives of this study were to determine the magnitude of impairment in everyday function in patients with mild cognitive impairment and Alzheimer'...

July 2010

The Internet-Based MGS2 Control Sample: Self Report of Mental Illness

Alan R. Sanders, M.D.,
Douglas F. Levinson, M.D.,
Jubao Duan, Ph.D.,
J. Michael Dennis, Ph.D.,
Rick Li, Ph.D.,
Kenneth S. Kendler, M.D.,
John P. Rice, Ph.D.,
Jianxin Shi, Ph.D.,
Bryan J. Mowry, M.D.,
Farooq Amin, M.D.,
Jeremy M. Silverman, Ph.D.,
Nancy G. Buccola, A.P.R.N., B.C.,
William F. Byerley, M.D.,
Donald W. Black, M.D.,
Robert Freedman, M.D.,
C. Robert Cloninger, M.D., and
Pablo V. Gejman, M.D.

Pages:854–865
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2010.09071050

Abstract
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ObjectiveThe Molecular Genetics of Schizophrenia (MGS2) project recruited an adult control sample of non-Hispanic European-ancestry (N=3,364) and African American (N=1,301) subjects. MethodSubjects gave consent to deposit phenotypic data and blood samples ...

Letter to the Editor

July 2010

A Clinical Significance Criterion Is Essential for Diagnosing Subthreshold Depression

Harald Baumeister, Ph.D.

Page:866
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2010.10030398

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July 2010

Reply to Baumeister Letter

Jerome C. Wakefield, Ph.D., D.S.W.,
Mark F. Schmitz, Ph.D., and
Judith C. Baer, Ph.D.

Pages:866–867
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2010.10030398r

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July 2010

Disguised Depression Deserves a Diagnosis

Nada L. Stotland, M.D., M.P.H.

Page:867
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2010.10030391

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July 2010

Reply to Stotland Letter

Jerome C. Wakefield, Ph.D., D.S.W.,
Mark F. Schmitz, Ph.D., and
Judith C. Baer, Ph.D.

Pages:867–868
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2010.10030391r

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July 2010

Substance Abuse and Switch From Depression to Mania in Bipolar Disorder

Joseph F. Goldberg, M.D.

Pages:868–869
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2010.10030367

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July 2010

Treatment With Depot Olanzapine

John Davis, M.D.

Page:868
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2010.10030396

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July 2010

Pregabalin Abuse, Dependence, and Withdrawal: A Case Report

Martin Grosshans, M.D.,
Jochen Mutschler, M.D.,
Derik Hermann, M.D.,
Oliver Klein, M.D.,
Harald Dressing, M.D.,
Falk Kiefer, M.D., and
Karl Mann, M.D.

Page:869
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2010.09091269

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July 2010

Reply to Goldberg Letter

Michael J. Ostacher, M.D., M.P.H., and
Roy H. Perlis, M.D., M.Sc.

Page:869
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2010.10030367r

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Correction

July 2010

Page:870
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2010.167.7.870

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July 2010

Page:870
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2010.167.7.870a

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Book Forum

July 2010

Nidotherapy: Harmonising the Environment With the Patient

Stefano Pallanti, M.D.

Page:871
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2009.09121740

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July 2010

Religion and Spirituality in Psychiatry

Marc Galanter, M.D.

Pages:871–872
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2010.10010027

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July 2010

In Her Wake: A Child Psychiatrist Explores the Mystery of Her Mother's Suicide

J. John Mann, M.D.

Pages:872–873
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2010.10010067

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July 2010

How to Practice Evidence-Based Psychiatry: Basic Principles and Case Studies

Mark S. Bauer, M.D.

Page:873
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2010.10010031

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Books Received

July 2010

Page:874
Published Online:1 July 2010

https://doi.org/10.1176/appi.ajp.2010.167.7.874

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