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May 01, 2024 | VOL. 181, NO. 5
CURRENT ISSUE
pp.347-460
April 01, 2024 | VOL. 181, NO. 4
pp.255-346
March 01, 2024 | VOL. 181, NO. 3
pp.171-254
February 01, 2024 | VOL. 181, NO. 2
pp.83-170
January 01, 2024 | VOL. 181, NO. 1
pp.1-82

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American Journal of Psychiatry

Volume 179, Issue 3

March 2022

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Editor's Note

March 2022

Insights Into the Genomic Underpinnings of Psychopathology

Ned H. Kalin, M.D.

Pages:171–174
Published Online:3 March 2022

https://doi.org/10.1176/appi.ajp.2021.22010056

First Page
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Editorials

March 2022

Auditory Steady-State Responses Probe GABA-Related Oscillatory Cortical Circuits and Their Relation to Neurodevelopmental Mental Disorders

Kit Melissa Larsen, M.Sc.

Pages:175–176
Published Online:3 March 2022

https://doi.org/10.1176/appi.ajp.2021.22010017

Full text
PDF/EPUB

March 2022

New Insights Into the Genetic Architecture of Obsessive-Compulsive Disorder: Another Step Along the Way

James F. Leckman, M.D., Ph.D.

Pages:177–179
Published Online:3 March 2022

https://doi.org/10.1176/appi.ajp.2021.22010027

First Page
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March 2022

Is Violent Suicide Molecularly Distinct?

Daniel Almeida, B.Sc.,
Gustavo Turecki, M.D., Ph.D.

Pages:180–181
Published Online:3 March 2022

https://doi.org/10.1176/appi.ajp.2021.22010026

Full text
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Reviews and Overviews

CME

March 2022

Putting Genetics to Work in the Psychiatric Clinic

Francis J. McMahon, M.D.

Pages:182–188
Published Online:3 March 2022

https://doi.org/10.1176/appi.ajp.2021.22010024

Abstract
Full text
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CME

Preview Abstract

The rapid progress in psychiatric genetics over the past 10 years, while exciting from a research perspective, has not yet had an impact on clinical practice. How will we really be able to put genetics to work in the psychiatric clinic? This overview will ...

March 2022

Genes To Mental Health (G2MH): A Framework to Map the Combined Effects of Rare and Common Variants on Dimensions of Cognition and Psychopathology

Sébastien Jacquemont, M.D.,
Guillaume Huguet, Ph.D.,
Marieke Klein, Ph.D.,
Samuel J.R.A. Chawner, Ph.D.,
Kirsten A. Donald, M.D., Ph.D.,
Marianne B.M. van den Bree, Ph.D.,
Jonathan Sebat, Ph.D.,
David H. Ledbetter, Ph.D.,
John N. Constantino, M.D.,
Rachel K. Earl, Ph.D.,
Donna M. McDonald-McGinn, M.S., L.C.G.C.,
Therese van Amelsvoort, M.D., Ph.D.,
Ann Swillen, Ph.D.,
Anne H. O’Donnell-Luria,
David C. Glahn, Ph.D.,
Laura Almasy, Ph.D.,
Evan E. Eichler, Ph.D.,
Stephen W. Scherer, Ph.D.,
Elise Robinson, Ph.D.,
Anne S. Bassett, M.D.,
Christa Lese Martin, Ph.D.,
Brenda Finucane, M.S.,
Jacob A.S. Vorstman, M.D., Ph.D.,
Carrie E. Bearden, Ph.D.,
Raquel E. Gur, M.D., Ph.D.,
and the Genes to Mental Health Network

Pages:189–203
Published Online:3 March 2022

https://doi.org/10.1176/appi.ajp.2021.21040432

Abstract
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Rare genomic disorders (RGDs) confer elevated risk for neurodevelopmental psychiatric disorders. In this era of intense genomics discoveries, the landscape of RGDs is rapidly evolving. However, there has not been comparable progress to date in scalable, ...

Articles

March 2022

Aberrant Developmental Patterns of Gamma-Band Response and Long-Range Communication Disruption in Youths With 22q11.2 Deletion Syndrome

Valentina Mancini, M.D.,
Vincent Rochas, Ph.D.,
Martin Seeber, Ph.D.,
Nicolas Roehri, Ph.D.,
Tonia A. Rihs, Ph.D.,
Victor Ferat, M.S.,
Maude Schneider, Ph.D.,
Peter J. Uhlhaas, Ph.D.,
Stephan Eliez, M.D.,
Christoph M. Michel, Ph.D.

Pages:204–215
Published Online:3 March 2022

https://doi.org/10.1176/appi.ajp.2021.21020190

Abstract
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Objective:Brain oscillations play a pivotal role in synchronizing responses of local and global ensembles of neurons. Patients with schizophrenia exhibit impairments in oscillatory response, which are thought to stem from abnormal maturation during ...

CMEVideo

March 2022

The Genetic Architecture of Obsessive-Compulsive Disorder: Contribution of Liability to OCD From Alleles Across the Frequency Spectrum

Behrang Mahjani, Ph.D.,
Lambertus Klei, Ph.D.,
Manuel Mattheisen, Ph.D.,
Matthew W. Halvorsen, Ph.D.,
Abraham Reichenberg, Ph.D.,
Kathryn Roeder, Ph.D.,
Nancy L. Pedersen, Ph.D.,
Julia Boberg, M.Sc.,
Elles de Schipper, Ph.D.,
Cynthia M. Bulik, Ph.D.,
Mikael Landén, M.D., Ph.D.,
Bengt Fundín, Ph.D.,
David Mataix-Cols, Ph.D.,
Sven Sandin, Ph.D.,
Christina M. Hultman, Ph.D.,
James J. Crowley, Ph.D.,
Joseph D. Buxbaum, Ph.D.,
Christian Rück, Ph.D., M.D.,
Bernie Devlin, Ph.D.,
Dorothy E. Grice, M.D.

Pages:216–225
Published Online:18 November 2021

https://doi.org/10.1176/appi.ajp.2021.21010101

Abstract
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CME

Preview Abstract

Objective:Obsessive-compulsive disorder (OCD) is known to be substantially heritable; however, the contribution of genetic variation across the allele frequency spectrum to this heritability remains uncertain. The authors used two new homogeneous cohorts ...

CMEAudioVideo

March 2022

Genetics and Brain Transcriptomics of Completed Suicide

Giovanna Punzi, M.D., Ph.D.,
Gianluca Ursini, M.D., Ph.D.,
Qiang Chen, Ph.D.,
Eugenia Radulescu, M.D., Ph.D.,
Ran Tao, Ph.D.,
Louise A. Huuki, P.S.M.,
Pasquale Di Carlo, M.D., Ph.D.,
Leonardo Collado-Torres, Ph.D.,
Joo Heon Shin, Ph.D.,
Roberto Catanesi, M.D.,
Andrew E. Jaffe, Ph.D.,
Thomas M. Hyde, M.D., Ph.D.,
Joel E. Kleinman, M.D., Ph.D.,
Trudy F.C. Mackay, Ph.D.,
Daniel R. Weinberger, M.D.

Pages:226–241
Published Online:3 March 2022

https://doi.org/10.1176/appi.ajp.2021.21030299

Abstract
Full text
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Supplement

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Objective:The authors sought to study the transcriptomic and genomic features of completed suicide by parsing the method chosen, to capture molecular correlates of the distinctive frame of mind of individuals who die by suicide, while reducing ...

Video

March 2022

Interindividual Differences in Cortical Thickness and Their Genomic Underpinnings in Autism Spectrum Disorder

Pages:242–254
Published Online:10 September 2021

https://doi.org/10.1176/appi.ajp.2021.20050630

Abstract
Full text
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Objective:Autism spectrum disorder (ASD) is accompanied by highly individualized neuroanatomical deviations that potentially map onto distinct genotypes and clinical phenotypes. This study aimed to link differences in brain anatomy to specific biological ...

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