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April 2014
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The American Journal of Psychiatry

Official Journal of the American Psychiatric Association Editor: Robert Freedman, M.D.
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Articles  |  April 1, 2014
Persistent THC Effect on Spatial Memory in Adolescent Monkeys

Adolescent rhesus monkeys administered D9-tetrahydrocannabinol (THC) 5 days a week for 6 months showed less practice-related improvement than unexposed monkeys on a test measuring working memory of spatial relationships. The exposed and unexposed monkeys did not differ in memory of colored objects. The discrepancy between spatial and object memory effects may stem from different developmental trajectories of underlying brain circuits.

Articles  |  April 1, 2014
Computerized CBT Plus Methadone for Cocaine Dependence

Computer-based training for cognitive-behavioral therapy (CBT4CBT) can increase abstinence rates in patients with cocaine dependence enrolled in methadone maintenance and weekly group sessions. The 47 patients randomly assigned to CBT4CBT completed five of seven modules, on average, over 8 weeks of CBT. The proportion of patients abstinent for 3 weeks at the end of treatment was 36% for CBT and 17% for treatment as usual.

Reviews and Overviews  |  April 1, 2014
Antidepressant-Induced Liver Injury

There are no strategies yet for preventing antidepressant-induced adverse hepatic events, but early detection by aminotransferase surveillance is essential, as drug-induced liver injury from antidepressants, although rare, may be irreversible in at-risk patients. Age and polypharmacy are two of several critical factors to consider when prescribing antidepressants.

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The American Journal of Psychiatry was named one of the 100 most influential journals in biology and medicine over the last 100 years by the Special Libraries Association