Comparative Risk of Mortality Among Psychotropic Medications in Dementia
Haloperidol had 1.5 times the risk of mortality of other psychotropics in patients with dementia studied in an outpatient VA setting. Risperidone, valproic acid and derivatives, and olanzapine had intermediate risk, and quetiapine had the lowest risk. Haloperidol was more frequently prescribed by nonpsychiatrists and more often in older, medically ill African Americans. Quetiapine was prescribed in lower doses, often for less ill patients, but was associated with increased parkinsonian symptoms. The increased risk of haloperidol was primarily in the first 30 days. The efficacy of quetiapine in the behavioral disturbances associated with dementia is questionable, whereas risperidone and olanzapine have significant beneficial effects and therefore would be preferred for treatment.