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April 2014
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The American Journal of Psychiatry

Official Journal of the American Psychiatric Association Editor: Robert Freedman, M.D.
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Articles  |  April 1, 2014
Influence of Genetics on Topiramate Treatment for Heavy Drinkers

Heavy drinkers trying to cut back but not completely eliminate their alcohol intake were treated with topiramate as an adjunct to counseling and reduced their drinking more rapidly than patients given placebo. The effect of topiramate was significant only in patients with a specific gene variation, the CC genotype of the GRIK1 polymorphism, offering a way to identify heavy drinkers who are likely to respond well to this treatment.

Articles  |  April 1, 2014
Different Pathways to Depression in Women and Men

Personality and failures in interpersonal relationships play a stronger etiologic role in major depression for women, but childhood sexual abuse, externalizing psychopathology, prior depression, and acute financial, occupational, or legal stress were stronger etiologic pathways to depression for men. The sex differences in these pathways offer a road map for clinicians in addressing psychological issues important to their patients.

Articles  |  April 1, 2014
Persistent THC Effect on Spatial Memory in Adolescent Monkeys

Adolescent rhesus monkeys administered D9-tetrahydrocannabinol (THC) 5 days a week for 6 months showed less practice-related improvement than unexposed monkeys on a test measuring working memory of spatial relationships. The exposed and unexposed monkeys did not differ in memory of colored objects. The discrepancy between spatial and object memory effects may stem from different developmental trajectories of underlying brain circuits.

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The American Journal of Psychiatry was named one of the 100 most influential journals in biology and medicine over the last 100 years by the Special Libraries Association