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Lower β2*-Nicotinic Acetylcholine Receptor Availability in Smokers With Schizophrenia

FIGURE 1.

FIGURE 1. Individual Values for Regional Availability of β2*-Nicotinic Acetylcholine Receptors in Smokers With Schizophrenia and Comparison Smokersa

a Determined with SPECT imaging after 5–7 days of abstinence. VT is the volume of distribution, and fp is the free plasma fraction. The horizontal line in each scatter plot represents the group mean value.

b Significant group difference (p<0.05, MANOVA).

c Average of the values for the caudate and putamen.

FIGURE 2.

FIGURE 2. Relationships Between Regional β2*-Nicotinic Acetylcholine Receptor Availability and Negative Symptoms in 11 Smokers With Schizophreniaa

a Receptor availability was determined with SPECT imaging after 5–7 days of abstinence. VT is the volume of distribution, and fp is the free plasma fraction. The line in each scatter plot represents the correlation line of best fit.

b Significant correlation (p<0.05, Pearson correlation).

c Average of the values for the caudate and putamen.