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Lithium and tryptophan augmentation in clomipramine-resistant obsessive- compulsive disorder

Published Online:https://doi.org/10.1176/ajp.141.10.1283

Obsessive-compulsive patients with symptoms resistant to clomipramine were treated by lithium or L-tryptophan augmentation. The improvement noted supports the hypothesis that increasing serotonergic neurotransmission ameliorates obsessive symptoms.

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