Sertraline in obsessive-compulsive disorder: a double-blind comparison with placebo [published erratum appears in Am J Psychiatry 1990 Oct;147(10):1393]
Abstract
Many agents that affect the brain's serotonergic system appear to be at least partially effective in the treatment of patients with obsessive- compulsive disorder. However, in this 10-week double-blind trial in which 10 patients received sertraline and nine received placebo, sertraline was ineffective according to four measures of obsessive- compulsive symptoms. The authors discuss the implications of these preliminary findings for the serotonergic theory of obsessive- compulsive disorder and the need to explore the role of other neurochemical systems in this disorder.
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