Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Yatham, L. N. Articles by Ruth, T. J. Search for Related Content PubMed Citation Articles by Yatham, L. N. Articles by Ruth, T. J. Bipolar Disorder Anticonvulsants PET

PET Study of [¹⁸F]6-Fluoro-L-Dopa Uptake in Neuroleptic- and Mood-Stabilizer-Naive First-Episode Nonpsychotic Mania: Effects of Treatment With Divalproex Sodium

OBJECTIVE: Although dopaminergic hyperactivity has been implicated in mania, the precise location in the brain of the abnormality is unclear. This study assessed presynaptic dopamine function in neuroleptic- and mood-stabilizer-naive nonpsychotic first-episode manic patients before and after treatment with divalproex sodium by measuring [¹⁸F]6-fluoro-L-dopa ([¹⁸F]DOPA) uptake in the striatum with positron emission tomography (PET). METHOD: Thirteen patients with DSM-IV bipolar I disorder, manic episode, and 13 healthy comparison subjects underwent [¹⁸F]DOPA PET scans. Ten of the 13 patients had repeat PET scans 2–6 weeks after beginning treatment with divalproex sodium monotherapy. [¹⁸F]DOPA uptake rate constants (K_i values) in the striatum were calculated by using graphical analysis with activity from the occipital cortex as the input function. RESULTS: No significant differences in [¹⁸F]DOPA uptake rate constants in the striatum were found between the manic patients and the comparison subjects. After treatment with divalproex sodium, [¹⁸F]DOPA rate constants were significantly reduced in the patients and were lower in the patients than in the comparison subjects. CONCLUSIONS: Although presynaptic dopamine function as reflected by [¹⁸F]DOPA uptake is not altered in mania, presynaptic dopamine function in manic patients was lower after treatment with divalproex sodium.

This article has been cited by other articles:

				Y. Kumakura and P. Cumming PET Studies of Cerebral Levodopa Metabolism: A Review of Clinical Findings and Modeling Approaches Neuroscientist, December 1, 2009; 15(6): 635 - 650. [Abstract] [PDF]

				O. D. Howes and S. Kapur The Dopamine Hypothesis of Schizophrenia: Version III--The Final Common Pathway Schizophr Bull, May 1, 2009; 35(3): 549 - 562. [Abstract] [Full Text] [PDF]

				S. Reeves, R. Brown, R. Howard, and P. Grasby Increased striatal dopamine (D2/D3) receptor availability and delusions in Alzheimer disease Neurology, February 10, 2009; 72(6): 528 - 534. [Abstract] [Full Text] [PDF]

				O. D. Howes, A. J. Montgomery, M.-C. Asselin, R. M. Murray, I. Valli, P. Tabraham, E. Bramon-Bosch, L. Valmaggia, L. Johns, M. Broome, et al. Elevated Striatal Dopamine Function Linked to Prodromal Signs of Schizophrenia Arch Gen Psychiatry, January 1, 2009; 66(1): 13 - 20. [Abstract] [Full Text] [PDF]

				O. D. HOWES, A. J. MONTGOMERY, M. ASSELIN, R. M. MURRAY, P. M. GRASBY, and P. K. McGUIRE Molecular imaging studies of the striatal dopaminergic system in psychosis and predictions for the prodromal phase of psychosis The British Journal of Psychiatry, December 1, 2007; 191(51): s13 - s18. [Abstract] [Full Text] [PDF]

				M. Mazza, M. Di Nicola, G. D. Marca, L. Janiri, P. Bria, and S. Mazza Bipolar Disorder and Epilepsy: A Bidirectional Relation? Neurobiological Underpinnings, Current Hypotheses, and Future Research Directions Neuroscientist, August 1, 2007; 13(4): 392 - 404. [Abstract] [PDF]

				J. B. Lohr and M. P. Caligiuri Abnormalities in Motor Physiology in Bipolar Disorder J Neuropsychiatry Clin Neurosci, August 1, 2006; 18(3): 342 - 349. [Abstract] [Full Text] [PDF]

				J. Hwang, I. K. Lyoo, S. R. Dager, S. D. Friedman, J. S. Oh, J. Y. Lee, S. J. Kim, D. L. Dunner, and P. F. Renshaw Basal Ganglia Shape Alterations in Bipolar Disorder Am J Psychiatry, February 1, 2006; 163(2): 276 - 285. [Abstract] [Full Text] [PDF]

				A. Biraben, F. Semah, M. -J. Ribeiro, G. Douaud, P. Remy, and A. Depaulis PET evidence for a role of the basal ganglia in patients with ring chromosome 20 epilepsy Neurology, July 13, 2004; 63(1): 73 - 77. [Abstract] [Full Text] [PDF]

				L. N. Yatham, P. F. Liddle, R. W. Lam, I-S. Shiah, C. Lane, A. J. Stoessl, V. Sossi, and T. J. Ruth PET Study of the Effects of Valproate on Dopamine D2 Receptors in Neuroleptic- and Mood-Stabilizer-Naive Patients With Nonpsychotic Mania Am J Psychiatry, October 1, 2002; 159(10): 1718 - 1723. [Abstract] [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2002 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us