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American Journal of Psychiatry

Volume 178, Issue 5

May 2021

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Editor's Note

May 2021

Scientific Advances Supporting New and Improved Treatment Strategies in Psychiatry

Ned H. Kalin, M.D.

Pages:365–368
Published Online:12 May 2021

https://doi.org/10.1176/appi.ajp.2021.21030290

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Editorials

May 2021

Better Evidence for Pharmacological Maintenance Treatment in Nonaffective Psychoses: Implications for Relapse Prevention

William G. Honer, M.D.

Pages:369–371
Published Online:12 May 2021

https://doi.org/10.1176/appi.ajp.2021.21030281

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May 2021

Can Target Engagement Studies Miss Their Targets and Mislead Drug Development?

Alan F. Schatzberg, M.D.

Pages:372–374
Published Online:12 May 2021

https://doi.org/10.1176/appi.ajp.2020.21030247

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May 2021

Medications to Treat Alcohol Use Disorder: Targeting the Dark Side

Barbara J. Mason, Ph.D.

Pages:375–377
Published Online:12 May 2021

https://doi.org/10.1176/appi.ajp.2021.21030286

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May 2021

Lather, Rinse, Repeat? Breaking Repetitive Behaviors With Repetitive Stimulation

Jennifer I. Lissemore, M.Sc.,
Nolan R. Williams, M.D.

Pages:378–380
Published Online:12 May 2021

https://doi.org/10.1176/appi.ajp.2020.21030265

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Commentary

May 2021

Electroconvulsive Therapy Is an Essential Procedure

Daniel F. Maixner, M.D.,
Richard Weiner, M.D., Ph.D.,
Irving M. Reti, M.B.B.S.,
Adriana P. Hermida, M.D.,
Mustafa M. Husain, M.D.,
Dane Larsen, B.A.,
William M. McDonald, M.D.

Pages:381–382
Published Online:12 May 2021

https://doi.org/10.1176/appi.ajp.2020.20111647

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Special Article

Video

May 2021

Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation

Roger S. McIntyre, M.D.,
Joshua D. Rosenblat, M.D., M.Sc.,
Charles B. Nemeroff, M.D., Ph.D.,
Gerard Sanacora, M.D., Ph.D.,
James W. Murrough, M.D., Ph.D.,
Michael Berk, Ph.D., M.B.B.Ch.,
Elisa Brietzke, M.D., Ph.D.,
Seetal Dodd, Ph.D.,
Philip Gorwood, M.D., Ph.D.,
Roger Ho, M.D., M.B.B.S.,
Dan V. Iosifescu, M.D.,
Carlos Lopez Jaramillo, M.D., Ph.D.,
Siegfried Kasper, M.D.,
Kevin Kratiuk, B.Pharm.,
Jung Goo Lee, M.D., Ph.D.,
Yena Lee, H.B.Sc.,
Leanna M.W. Lui,
Rodrigo B. Mansur, M.D., Ph.D.,
George I. Papakostas, M.D.,
Mehala Subramaniapillai, M.Sc.,
Michael Thase, M.D.,
Eduard Vieta, M.D., Ph.D.,
Allan H. Young, M.Phil., M.B.Ch.B.,
Carlos A. Zarate, M.D.,
Stephen Stahl, M.D., Ph.D.

Pages:383–399
Published Online:17 March 2021

https://doi.org/10.1176/appi.ajp.2020.20081251

Abstract
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Replicated international studies have underscored the human and societal costs associated with major depressive disorder. Despite the proven efficacy of monoamine-based antidepressants in major depression, the majority of treated individuals fail to ...

Reviews and Overviews

May 2021

Examining and Modulating Neural Circuits in Psychiatric Disorders With Transcranial Magnetic Stimulation and Electroencephalography: Present Practices and Future Developments

Fabio Ferrarelli, M.D., Ph.D.,
Mary L. Phillips, M.D.

Pages:400–413
Published Online:3 March 2021

https://doi.org/10.1176/appi.ajp.2020.20071050

Abstract
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Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation technique uniquely equipped to both examine and modulate neural systems and related cognitive and behavioral functions in humans. As an examination tool, TMS can be used in ...

Articles

CMEAudio

May 2021

Quality of Outpatient Depression Treatment in Patients With Comorbid Substance Use Disorder

Lara N. Coughlin, Ph.D.,
Paul Pfeiffer, M.D., M.S.,
Dara Ganoczy, M.P.H.,
Lewei A. Lin, M.D., M.S.

Pages:414–423
Published Online:29 October 2020

https://doi.org/10.1176/appi.ajp.2020.20040454

Abstract
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Objective: Clinical practice guidelines recommend concurrent treatment of co-occurring depression and substance use disorders; however, the degree to which patients with substance use disorders receive guideline-concordant treatment for depression is ...

CME

May 2021

Maintenance Treatment With Long-Acting Injectable Antipsychotics for People With Nonaffective Psychoses: A Network Meta-Analysis

Giovanni Ostuzzi, M.D., Ph.D.,
Federico Bertolini, M.D.,
Cinzia Del Giovane, Ph.D.,
Federico Tedeschi, Ph.D.,
Chiara Bovo, M.D.,
Chiara Gastaldon, M.D.,
Michela Nosé, M.D., Ph.D.,
Filippo Ogheri, M.D.,
Davide Papola, M.D.,
Marianna Purgato, Psy.D., Ph.D.,
Giulia Turrini, Psy.D.,
Christoph U. Correll, M.D.,
Corrado Barbui, M.D.

Pages:424–436
Published Online:18 February 2021

https://doi.org/10.1176/appi.ajp.2020.20071120

Abstract
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Objective: This study compared relapse prevention and acceptability of long-acting injectable (LAI) antipsychotics in the maintenance treatment of adults with nonaffective psychoses. Methods: The authors searched MEDLINE, Embase, PsycINFO, CINAHL, ...

Video

May 2021

Impact of the KCNQ2/3 Channel Opener Ezogabine on Reward Circuit Activity and Clinical Symptoms in Depression: Results From a Randomized Controlled Trial

Sara Costi, M.D.,
Laurel S. Morris, Ph.D.,
Katherine A. Kirkwood, M.S.,
Megan Hoch, M.A.,
Morgan Corniquel, M.A.,
Brittany Vo-Le, M.S.,
Tabish Iqbal, M.B.B.S.,
Nisha Chadha, M.D.,
Diego A. Pizzagalli, Ph.D.,
Alexis Whitton, Ph.D.,
Laura Bevilacqua, M.D., Ph.D.,
Manish K. Jha, M.D.,
Stefan Ursu, M.D., Ph.D.,
Alan C. Swann, M.D.,
Katherine A. Collins, Ph.D.,
Ramiro Salas, Ph.D.,
Emilia Bagiella, Ph.D.,
Michael K. Parides, Ph.D.,
Emily R. Stern, Ph.D.,
Dan V. Iosifescu, M.D.,
Ming-Hu Han, Ph.D.,
Sanjay J. Mathew, M.D.,
James W. Murrough, M.D., Ph.D.

Pages:437–446
Published Online:3 March 2021

https://doi.org/10.1176/appi.ajp.2020.20050653

Abstract
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Objective: Preclinical studies point to the KCNQ2/3 potassium channel as a novel target for the treatment of depression and anhedonia, a reduced ability to experience pleasure. The authors conducted the first randomized placebo-controlled trial testing ...

CME

May 2021

Moderation of Prazosin’s Efficacy by Alcohol Withdrawal Symptoms

Rajita Sinha, Ph.D.,
Stephanie Wemm, Ph.D.,
Nia Fogelman, Ph.D.,
Verica Milivojevic, Ph.D.,
Peter M. Morgan, M.D., Ph.D.,
Gustavo A. Angarita, M.D.,
Gretchen Hermes, M.D., Ph.D.,
Helen C. Fox, Ph.D.

Pages:447–458
Published Online:19 November 2020

https://doi.org/10.1176/appi.ajp.2020.20050609

Abstract
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Objective: Alcohol use disorder (AUD) is a leading cause of global disease burden. Chronic, heavy use increases the likelihood of alcohol withdrawal symptoms and associated secondary outcomes of alcohol craving and mood, anxiety, and sleep disturbances, ...

Video

May 2021

Effect of Experimental Manipulation of the Orbitofrontal Cortex on Short-Term Markers of Compulsive Behavior: A Theta Burst Stimulation Study

Rebecca B. Price, Ph.D.,
Claire M. Gillan, Ph.D.,
Colleen Hanlon, Ph.D.,
Fabio Ferrarelli, M.D., Ph.D.,
Tae Kim, Ph.D.,
Helmet T. Karim, Ph.D.,
Marlee Renard, B.A.,
Rachel Kaskie, B.S.,
Michelle Degutis, B.S.,
Anna Wears, B.A.,
Emelina P. Vienneau, B.S.E.,
Angel V. Peterchev, Ph.D.,
Vanessa Brown, Ph.D.,
Greg J. Siegle, Ph.D.,
Meredith L Wallace, Ph.D.,
Susanne E. Ahmari, M.D., Ph.D.

Pages:459–468
Published Online:17 March 2021

https://doi.org/10.1176/appi.ajp.2020.20060821

Abstract
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Objective: Compulsive behaviors are a core feature of obsessive-compulsive spectrum disorders but appear across a broad spectrum of psychological conditions. It is thought that compulsions reflect a failure to override habitual behaviors “stamped in” ...

Letters to the Editor

May 2021

Ubiquitous Dopamine Deficit Hypotheses in Cocaine Use Disorder Lack Support

Marco Leyton, Ph.D.

Page:469
Published Online:12 May 2021

https://doi.org/10.1176/appi.ajp.2021.20111581

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May 2021

Ubiquitous Dopamine Deficit Hypotheses in Cocaine Use Disorder Lack Support: Response to Leyton

Clifford M. Cassidy, Ph.D.,
Anna B. Konova, Ph.D.,
Anissa Abi-Dargham, M.D.,
Diana Martinez, M.D.,
Guillermo Horga, M.D., Ph.D.

Pages:469–470
Published Online:12 May 2021

https://doi.org/10.1176/appi.ajp.2020.20111581r

Full text
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