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American Journal of Psychiatry

Volume 169, Issue 12

December 2012

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In This Issue

December 2012

Page:A24
Published Online:1 December 2012

https://doi.org/10.1176/appi.ajp.2012.16912issue

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Editorials

December 2012

The Evolving Story of Folate in Depression and the Therapeutic Potential of l-Methylfolate

J. Craig Nelson, M.D.

Pages:1223–1225
Published Online:1 December 2012

https://doi.org/10.1176/appi.ajp.2012.12091207

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December 2012

Loss of Semantic Knowledge in Mild Cognitive Impairment

David P. Salmon, Ph.D.

Pages:1226–1229
Published Online:1 December 2012

https://doi.org/10.1176/appi.ajp.2012.12101262

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December 2012

Diffusion Tensor Imaging and Mild Traumatic Brain Injury in Soldiers: Abnormal Findings, Uncertain Implications

Jonathan M. Silver, M.D.

Pages:1230–1232
Published Online:1 December 2012

https://doi.org/10.1176/appi.ajp.2012.12091230

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December 2012

Robert Freedman, M.D.,
David A. Lewis, M.D.,
Robert Michels, M.D.,
Daniel S. Pine, M.D.,
Susan K. Schultz, M.D.,
Carol A. Tamminga, M.D., and
Monifa Seawell, M.D.

Pages:1233–1237
Published Online:1 December 2012

https://doi.org/10.1176/appi.ajp.2012.12091250

Abstract
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The Editors offer their personal selections of the articles this year they found particularly interesting and important. Also available in Spanish.

Treatment in Psychiatry

December 2012

ECT in Treatment-Resistant Depression

Charles H. Kellner, M.D.,
Robert M. Greenberg, M.D.,
James W. Murrough, M.D.,
Ethan O. Bryson, M.D.,
Mimi C. Briggs, B.A., and
Rosa M. Pasculli, B.A.

Pages:1238–1244
Published Online:1 December 2012

https://doi.org/10.1176/appi.ajp.2012.12050648

Abstract
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ECT is often effective for severely depressed patients who have not responded to multiple medication trials or who are at imminent risk of suicide. This issue's Treatment in Psychiatry highlights the safety and efficacy of ECT while stressing the ...

Images in Psychiatry

December 2012

Revealing the Mind’s Eye: Bringing (Mental) Images Into Psychiatry

Martina Di Simplicio, M.D., Ph.D.,
Josephine E. McInerney,
Guy M. Goodwin, M.D., D.Phil., F.R.C.Psych., F.Med.Sci.,
Mary-Jane Attenburrow, M.D., F.R.C.Psych., and
Emily A. Holmes, B.A., Ph.D., D.Clin.

Pages:1245–1246
Published Online:1 December 2012

https://doi.org/10.1176/appi.ajp.2012.12040499

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Reviews and Overviews

December 2012

The Nature of the Association Between Childhood ADHD and the Development of Bipolar Disorder: A Review of Prospective High-Risk Studies

Anne Duffy, M.D., F.R.C.P.C.

Pages:1247–1255
Published Online:1 December 2012

https://doi.org/10.1176/appi.ajp.2012.11111725

Abstract
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ObjectiveThe author reviewed prospective longitudinal studies of the offspring of parents with bipolar disorder to inform our understanding of the nature of the association between childhood ADHD and the risk of developing bipolar disorder in adolescence ...

December 2012

Examining the Comorbidity Between Attention Deficit Hyperactivity Disorder and Bipolar I Disorder: A Meta-Analysis of Family Genetic Studies

Stephen V. Faraone, Ph.D.,
Joseph Biederman, M.D., and
Janet Wozniak, M.D.

Pages:1256–1266
Published Online:1 December 2012

https://doi.org/10.1176/appi.ajp.2012.12010087

Abstract
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ObjectiveThe existence of comorbidity between attention deficit hyperactivity disorder (ADHD) and bipolar I disorder has been documented in clinical and epidemiological studies, in studies of children and adults, and in diagnosed ADHD and bipolar I ...

Articles

December 2012

l-Methylfolate as Adjunctive Therapy for SSRI-Resistant Major Depression: Results of Two Randomized, Double-Blind, Parallel-Sequential Trials

George I. Papakostas, M.D.,
Richard C. Shelton, M.D.,
John M. Zajecka, M.D.,
Bijan Etemad, M.D.,
Karl Rickels, M.D.,
Alisabet Clain, M.S.,
Lee Baer, Ph.D.,
Elizabeth D. Dalton, B.A.,
Garret R. Sacco, B.A.,
David Schoenfeld, Ph.D.,
Michael Pencina, Ph.D.,
Allison Meisner, M.A.,
Teodoro Bottiglieri, Ph.D.,
Erik Nelson, M.D.,
David Mischoulon, M.D., Ph.D.,
Jonathan E. Alpert, M.D., Ph.D.,
James G. Barbee, M.D.,
Sidney Zisook, M.D., and
Maurizio Fava, M.D.

Pages:1267–1274
Published Online:1 December 2012

https://doi.org/10.1176/appi.ajp.2012.11071114

Abstract
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Patients with major depression who have an insufficient response to selective serotonin reuptake inhibitors (SSRIs) may benefit from the addition of 15 mg/day of l-methylfolate, the only form of folate that crosses the blood-brain barrier. Adding 7.5 mg/...

December 2012

Semantic Distance Abnormalities in Mild Cognitive Impairment: Their Nature and Relationship to Function

Brady C. Kirchberg, B.A.,
Jessica R. Cohen, Ph.D.,
Margarita B. Adelsky, Ph.D.,
Justin J. Buthorn, B.S.,
Jesus J. Gomar, Ph.D.,
Marc Gordon, M.D.,
Jeremy Koppel, M.D.,
Erica Christen, M.S., R.N.,
Concepcion Conejero-Goldberg, M.D., Ph.D.,
Peter Davies, Ph.D., and
Terry E. Goldberg, Ph.D.

Pages:1275–1283
Published Online:1 December 2012

https://doi.org/10.1176/appi.ajp.2012.12030383

Abstract
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ObjectiveThe authors sought to directly examine compromises in the semantic system in mild cognitive impairment and their possible relationship to everyday functional competencies.MethodStudy participants were 25 patients who met criteria for amnestic ...

December 2012

White Matter Abnormalities in Veterans With Mild Traumatic Brain Injury

Ricardo E. Jorge, M.D.,
Laura Acion, Ph.D., M.P.H.,
Tonya White, M.D., Ph.D.,
Diana Tordesillas-Gutierrez, Ph.D.,
Ronald Pierson, M.S.,
Benedicto Crespo-Facorro, M.D., and
Vincent A. Magnotta, Ph.D.

Pages:1284–1291
Published Online:1 December 2012

https://doi.org/10.1176/appi.ajp.2012.12050600

Abstract
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ObjectiveIt has been estimated that 10%–20% of U.S. veterans of the wars in Iraq and Afghanistan experienced mild traumatic brain injury (TBI), mostly secondary to blast exposure. Diffusion tensor imaging (DTI) may detect subtle white matter changes in ...

December 2012

Up-Regulation of NOTCH4 Gene Expression in Bipolar Disorder

Ingrid Dieset, M.D.,
Srdjan Djurovic, Ph.D.,
Martin Tesli, M.D.,
Sigrun Hope, M.D.,
Morten Mattingsdal, Ph.D.,
Annika Michelsen, Ph.D.,
Inge Joa, Ph.D.,
Tor Ketil Larsen, M.D., Ph.D.,
Ingrid Agartz, M.D., Ph.D.,
Ingrid Melle, M.D., Ph.D.,
Jan Ivar Røssberg, M.D., Ph.D.,
Pål Aukrust, M.D., Ph.D.,
Ole A. Andreassen, M.D., Ph.D., and
Thor Ueland, Ph.D.

Pages:1292–1300
Published Online:1 December 2012

https://doi.org/10.1176/appi.ajp.2012.11091431

Abstract
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ObjectiveImmunopathogenic mechanisms have been implicated in schizophrenia and bipolar disorder, and genome-wide association studies (GWAS) point to the major histocompatibility complex, a region that contains many immune-related genes. One of the ...

December 2012

Evidence That Schizophrenia Risk Variation in the ZNF804A Gene Exerts Its Effects During Fetal Brain Development

Matthew J. Hill, Ph.D., and
Nicholas J. Bray, Ph.D.

Pages:1301–1308
Published Online:1 December 2012

https://doi.org/10.1176/appi.ajp.2012.11121845

Abstract
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ObjectiveThe single-nucleotide polymorphism rs1344706, located within an intron of the ZNF804A gene, exhibits genome-wide significant association with schizophrenia. Although genotype at rs1344706 is associated with altered functional brain connectivity, ...

December 2012

Genome-Wide Association Study of Clinical Dimensions of Schizophrenia: Polygenic Effect on Disorganized Symptoms

Ayman H. Fanous, M.D.,
Baiyu Zhou, Ph.D.,
Steven H. Aggen, Ph.D.,
Sarah E. Bergen, Ph.D.,
Richard L. Amdur, Ph.D.,
Jubao Duan, Ph.D.,
Alan R. Sanders, M.D.,
Jianxin Shi, Ph.D.,
Bryan J. Mowry, M.D., F.R.A.N.Z.C.P.,
Ann Olincy, M.D.,
Farooq Amin, M.D.,
C. Robert Cloninger, M.D.,
Jeremy M. Silverman, Ph.D.,
Nancy G. Buccola, M.S.N., A.P.R.N.,
William F. Byerley, M.D.,
Donald W. Black, M.D.,
Robert Freedman, M.D.,
Frank Dudbridge, Ph.D.,
Peter A. Holmans, Ph.D.,
Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium,
Stephan Ripke, M.D.,
Pablo V. Gejman, M.D.,
Kenneth S. Kendler, M.D., and
Douglas F. Levinson, M.D.

Pages:1309–1317
Published Online:1 December 2012

https://doi.org/10.1176/appi.ajp.2012.12020218

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ObjectiveMultiple sources of evidence suggest that genetic factors influence variation in clinical features of schizophrenia. The authors present the first genome-wide association study (GWAS) of dimensional symptom scores among individuals with ...

Letters to the Editor

December 2012

Genetic Variation in KCNH2 and a Unique hERG Isoform in Patients With Schizophrenia: Efficacy-Safety Link

Barbara Warner, M.D.

Page:1318
Published Online:1 December 2012

https://doi.org/10.1176/appi.ajp.2012.12070966

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December 2012

Response to Warner Letter

Fengyu Zhang, Ph.D.,

José A. Apud, M.D., Ph.D.,

Kristin L. Bigos, Ph.D., and
Daniel R. Weinberger, M.D.

Pages:1318–1319
Published Online:1 December 2012

https://doi.org/10.1176/appi.ajp.2012.12070966r

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December 2012

Unplanned Pregnancies in Adolescents With Bipolar Disorder

Jaimee L. Heffner, Ph.D.,

Melissa P. DelBello, M.D.,
David E. Fleck, Ph.D.,
Caleb M. Adler, M.D., and
Stephen M. Strakowski, M.D.

Page:1319
Published Online:1 December 2012

https://doi.org/10.1176/appi.ajp.2012.12060828

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December 2012

Monoamine Oxidase Inhibitors Potentiate the Effects of Deep Brain Stimulation

Clement Hamani, M.D., Ph.D.,
Peter Giacobbe, M.D., F.R.C.P.C.,
Mustansir Diwan, M.Sc.,
Eliane S. Balbino,
Junchao Tong, Ph.D.,
Alanna Bridgman,
Nir Lipsman, M.D.,
Andres M. Lozano, M.D., Ph.D.,
Sidney H. Kennedy, M.D., F.R.C.P.C., and
José N. Nobrega, Ph.D.

Pages:1320–1321
Published Online:1 December 2012

https://doi.org/10.1176/appi.ajp.2012.12060754

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Corrections

December 2012

Page:1321
Published Online:1 December 2012

https://doi.org/10.1176/appi.ajp.2012.1691201

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December 2012

Page:1321
Published Online:1 December 2012

https://doi.org/10.1176/appi.ajp.2012.1691202

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Book Forum

December 2012

Hidden in the Shadow of the Master: the Model-Wives of Cézanne, Monet, and Rodin

Natalie L. Rasgon, M.D., Ph.D.

Pages:1322–1323
Published Online:1 December 2012

https://doi.org/10.1176/appi.ajp.2012.12101274

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December 2012

Bring Up the Bodies

Barbara Milrod, M.D.

Pages:1323–1324
Published Online:1 December 2012

https://doi.org/10.1176/appi.ajp.2012.12060834

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December 2012

J. John Mann, M.D.

Page:1323
Published Online:1 December 2012

https://doi.org/10.1176/appi.ajp.2012.12101273

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December 2012

Oblivion: A Memoir of Hector Abad

Robert Freedman, M.D.

Pages:1324–1325
Published Online:1 December 2012

https://doi.org/10.1176/appi.ajp.2012.12030346

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Books Received

December 2012

Page:1326
Published Online:1 December 2012

https://doi.org/10.1176/appi.ajp.2012.16912Books

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In Appreciation

December 2012

Reviewers for The American Journal of Psychiatry

Pages:1327–1332
Published Online:1 December 2012

https://doi.org/10.1176/appi.ajp.2012.16912reviewers

First Page
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