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American Journal of Psychiatry

Volume 168, Issue 7

July 2011

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In This Issue

July 2011

Page:A28
Published Online:1 July 2011

https://doi.org/10.1176/appi.ajp.2011.168.7.a28

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Editorials

July 2011

When Is Polypharmacy an Advantage?

Carol A. Tamminga, M.D.

Page:663
Published Online:1 July 2011

https://doi.org/10.1176/appi.ajp.2011.11050695

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July 2011

The Search for Improved Antidepressant Strategies: Is Bigger Better?

William Coryell, M.D.

Pages:664–666
Published Online:1 July 2011

https://doi.org/10.1176/appi.ajp.2011.11030510

First Page
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July 2011

Antipsychotic Polypharmacy: Are Two Ever Better Than One?

Donald C. Goff, M.D., and
Lisa Dixon, M.D., M.P.H.

Pages:667–669
Published Online:1 July 2011

https://doi.org/10.1176/appi.ajp.2011.11020314

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July 2011

Adapting Treatment to Patient Problems

Charles P. O'Brien, M.D., Ph.D.

Pages:670–671
Published Online:1 July 2011

https://doi.org/10.1176/appi.ajp.2011.11040594

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Commentary

July 2011

Neuroscience, Clinical Evidence, and the Future of Psychiatric Classification in DSM-5

David J. Kupfer, M.D., and
Darrel A. Regier, M.D., M.P.H.

Pages:672–674
Published Online:1 July 2011

https://doi.org/10.1176/appi.ajp.2011.11020219

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Clinical Case Conference

July 2011

Buprenorphine for Prescription Opioid Addiction in a Patient With Depression and Alcohol Dependence

Marc J. Fishman, M.D.,
Li-Tzy Wu, Sc.D., and
George E. Woody, M.D.

Pages:675–679
Published Online:1 July 2011

https://doi.org/10.1176/appi.ajp.2010.10060879

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Images in Psychiatry

July 2011

Paul Cézanne, 1839–1906

Peter J. Buckley, M.D.

Page:680
Published Online:1 July 2011

https://doi.org/10.1176/appi.ajp.2011.11030394

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Reviews and Overviews

July 2011

A Systematic Review of Treatments for Refractory Depression in Older People

Claudia Cooper, Ph.D., M.R.C.Psych.,
Cornelius Katona, M.D., F.R.C.Psych.,
Kostas Lyketsos, M.D., M.H.S.,
Dan Blazer, M.D., Ph.D.,
Henry Brodaty, M.D., F.R.A.N.Z.C.P.,
Peter Rabins, M.D., M.P.H.,
Carlos Augusto de Mendonça Lima, M.D., D.Sci., and
Gill Livingston, M.D., F.R.C.Psych.

Pages:681–688
Published Online:1 July 2011

https://doi.org/10.1176/appi.ajp.2011.10081165

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Objective:The authors systematically reviewed the management of treatment-refractory depression in older people (defined as age 55 or older). Method:The authors conducted an electronic database search and reviewed the 14 articles that fit predetermined ...

Articles

July 2011

Combining Medications to Enhance Depression Outcomes (CO-MED): Acute and Long-Term Outcomes of a Single-Blind Randomized Study

A. John Rush, M.D.,
Madhukar H. Trivedi, M.D.,
Jonathan W. Stewart, M.D.,
Andrew A. Nierenberg, M.D.,
Maurizio Fava, M.D.,
Benji T. Kurian, M.D.,
Diane Warden, Ph.D.,
David W. Morris, Ph.D.,
James F. Luther, M.A.,
Mustafa M. Husain, M.D.,
Ian A. Cook, M.D.,
Richard C. Shelton, M.D.,
Ira M. Lesser, M.D.,
Susan G. Kornstein, M.D., and
Stephen R. Wisniewski, Ph.D.

Pages:689–701
Published Online:1 July 2011

https://doi.org/10.1176/appi.ajp.2011.10111645

Abstract
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Objective:Two antidepressant medication combinations were compared with selective serotonin reuptake inhibitor monotherapy to determine whether either combination produced a higher remission rate in first-step acute-phase (12 weeks) and long-term (7 ...

July 2011

Effectiveness of Switching From Antipsychotic Polypharmacy to Monotherapy

Susan M. Essock, Ph.D.,
Nina R. Schooler, Ph.D.,
T. Scott Stroup, M.D., M.P.H.,
Joseph P. McEvoy, M.D.,
Ingrid Rojas,
Carlos Jackson, Ph.D.,
Nancy H. Covell, Ph.D., and
The Schizophrenia Trials Network

Pages:702–708
Published Online:1 July 2011

https://doi.org/10.1176/appi.ajp.2011.10060908

Abstract
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Objective:This randomized trial addressed the risks and benefits of staying on antipsychotic polypharmacy or switching to monotherapy. Method:Adult outpatients with schizophrenia taking two antipsychotics (127 participants across 19 sites) were randomly ...

July 2011

Gabapentin Combined With Naltrexone for the Treatment of Alcohol Dependence

Raymond F. Anton, M.D.,
Hugh Myrick, M.D.,
Tara M. Wright, M.D.,
Patricia K. Latham, Ph.D.,
Alicia M. Baros, Ph.D.,
L. Randolph Waid, Ph.D., and
Patrick K. Randall, Ph.D.

Pages:709–717
Published Online:1 July 2011

https://doi.org/10.1176/appi.ajp.2011.10101436

Abstract
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Objective:Naltrexone, an efficacious medication for alcohol dependence, does not work for everyone. Symptoms such as insomnia and mood instability that are most evident during early abstinence might respond better to a different pharmacotherapy. ...

July 2011

Disruption in the Balance Between Goal-Directed Behavior and Habit Learning in Obsessive-Compulsive Disorder

Claire M. Gillan, B.A.,
Martina Papmeyer, M.A.,
Sharon Morein-Zamir, Ph.D.,
Barbara J. Sahakian, Ph.D.,
Naomi A. Fineberg, M.A., M.R.C.Psych.,
Trevor W. Robbins, Ph.D., and
Sanne de Wit, Ph.D.

Pages:718–726
Published Online:1 July 2011

https://doi.org/10.1176/appi.ajp.2011.10071062

Abstract
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Objective:Obsessive-compulsive disorder (OCD) is characterized by repetitive, ritualistic behaviors and thought patterns. Although patients with OCD report that these compulsive behaviors are unproductive and often senseless, they are unable to desist. ...

July 2011

Reduced Metabotropic Glutamate Receptor 5 Density in Major Depression Determined by [¹¹C]ABP688 PET and Postmortem Study

Alexandra Deschwanden, M.S.,
Beata Karolewicz, Ph.D.,
Anteneh M. Feyissa, M.D.,
Valerie Treyer, Ph.D.,
Simon M. Ametamey, Ph.D.,
Anass Johayem, Ph.D.,
Cyrill Burger, Ph.D.,
Yves P. Auberson, Ph.D.,
Judit Sovago, M.D., Ph.D.,
Craig A. Stockmeier, Ph.D.,
Alfred Buck, M.D., and
Gregor Hasler, M.D.

Pages:727–734
Published Online:1 July 2011

https://doi.org/10.1176/appi.ajp.2011.09111607

Abstract
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Supplement

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Objective:Clinical and preclinical evidence suggests a hyperactive glutamatergic system in clinical depression. Recently, the metabotropic glutamate receptor 5 (mGluR5) has been proposed as an attractive target for novel therapeutic approaches to ...

July 2011

Association of Predeployment Gaze Bias for Emotion Stimuli With Later Symptoms of PTSD and Depression in Soldiers Deployed in Iraq

Christopher G. Beevers, Ph.D.,
Han-Joo Lee, Ph.D.,
Tony T. Wells, M.A.,
Alissa J. Ellis, M.A., and
Michael J. Telch, Ph.D.

Pages:735–741
Published Online:1 July 2011

https://doi.org/10.1176/appi.ajp.2011.10091309

Abstract
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Objective:Biased processing of emotion stimuli is thought to confer vulnerability to psychopathology, but few longitudinal studies of this link have been conducted. The authors examined the relationship between predeployment gaze bias for emotion stimuli ...

July 2011

A Prospective 2-Year Study of Emergency Department Patients With Early-Phase Primary Psychosis or Substance-Induced Psychosis

Robert E. Drake, M.D., Ph.D.,
Carol L.M. Caton, Ph.D.,
Haiyi Xie, Ph.D.,
Eustace Hsu, M.A.,
Prakash Gorroochurn, Ph.D.,
Sharon Samet, Ph.D., L.C.S.W., and
Deborah S. Hasin, Ph.D.

Pages:742–748
Published Online:1 July 2011

https://doi.org/10.1176/appi.ajp.2011.10071051

Abstract
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Objective:The authors examined treatment utilization and outcomes over 2 years among patients admitted to emergency departments with early-phase primary or substance-induced psychosis. The main hypothesis was that patients with substance-induced psychosis ...

Letters to the Editor

July 2011

Comment on the Association of Stigma With Violence

Jason Matejkowski, Ph.D.,
Sara Cullen, M.S.W., and
Phyllis Solomon, Ph.D.

Page:749
Published Online:1 July 2011

https://doi.org/10.1176/appi.ajp.2011.11030412

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July 2011

Response to Matejkowski et al. Letter

E. Fuller Torrey, M.D.

Page:749
Published Online:1 July 2011

https://doi.org/10.1176/appi.ajp.2011.11030412r

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July 2011

Anti-NMDA Receptor Encephalitis Versus Pediatric Catatonia

Dirk Dhossche, M.D, Ph.D.,

Max Fink, M.D.,

Edward Shorter, Ph.D., and

Lee E. Wachtel, M.D.

Pages:749–750
Published Online:1 July 2011

https://doi.org/10.1176/appi.ajp.2011.11030471

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July 2011

Response to Dhossche et al. Letter

Meredith R. Chapman, M.D., and
Holly E. Vause, D.N.P., P.M.H.N.P.-B.C.

Pages:750–751
Published Online:1 July 2011

https://doi.org/10.1176/appi.ajp.2011.11030471r

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July 2011

Monitoring Ketamine Treatment Response in a Depressed Patient via Peripheral Mammalian Target of Rapamycin Activation

Magdalena C. Denk, M.D.,
Christiane Rewerts, M.T.L.A.,
Florian Holsboer, M.D., Ph.D.,
Angelika Erhardt-Lehmann, M.D., and
Christoph W. Turck, Ph.D.

Pages:751–752
Published Online:1 July 2011

https://doi.org/10.1176/appi.ajp.2011.11010128

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July 2011

The Asclepius: The Ancient Standard of Physicians

John A. Fromson, M.D.

Page:752
Published Online:1 July 2011

https://doi.org/10.1176/appi.ajp.2011.11040539

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Book Forum

July 2011

Downing Street Blues: A History of Depression and Other Mental Afflictions in British Prime Ministers

Gordon B. Parker, M.D., Ph.D.

Pages:753–754
Published Online:1 July 2011

https://doi.org/10.1176/appi.ajp.2011.11020195

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July 2011

Struck by Living: From Depression to Hope

Conrad M. Swartz, Ph.D., M.D.

Pages:754–755
Published Online:1 July 2011

https://doi.org/10.1176/appi.ajp.2011.11010100

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July 2011

GABA and Sleep: Molecular, Functional and Clinical Aspects

Martin Reite, M.D.

Page:755
Published Online:1 July 2011

https://doi.org/10.1176/appi.ajp.2011.11010133

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July 2011

Psychotherapy for the Treatment of Substance Abuse

Roger D. Weiss, M.D.

Pages:755–756
Published Online:1 July 2011

https://doi.org/10.1176/appi.ajp.2011.11010156

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Correction

July 2011

Page:756
Published Online:1 July 2011

https://doi.org/10.1176/appi.ajp.2011.168.7.756

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