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American Journal of Psychiatry

Volume 168, Issue 10

October 2011

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In This Issue

October 2011

Page:A34
Published Online:1 October 2011

https://doi.org/10.1176/appi.ajp.2011.168.a34

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Editorial

October 2011

Hard Outcomes: Clinical Trials to Reduce Suicide

Roy H. Perlis, M.D., M.Sc.

Pages:1009–1011
Published Online:1 October 2011

https://doi.org/10.1176/appi.ajp.2011.11081250

First Page
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October 2011

Anxiety Disorders and Antipsychotic Drugs: A Pressing Need for More Research

Alan Breier, M.D.

Pages:1012–1014
Published Online:1 October 2011

https://doi.org/10.1176/appi.ajp.2011.11071049

First Page
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October 2011

A New (Old) Treatment Option for Depression in Parkinson's Disease

Kevin J. Black, M.D.

Pages:1015–1016
Published Online:1 October 2011

https://doi.org/10.1176/appi.ajp.2011.11071124

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October 2011

Digging More Deeply for Genetic Effects in Psychiatric Illness

Linda Brzustowicz, M.D., and
Robert Freedman, M.D.

Pages:1017–1020
Published Online:1 October 2011

https://doi.org/10.1176/appi.ajp.2011.11060928

First Page
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APA Presidential Addresses

October 2011

Presidential Address: Transforming Mental Health Through Leadership, Discovery, and Collaboration

Carol A. Bernstein, M.D.

Pages:1021–1025
Published Online:1 October 2011

https://doi.org/10.1176/appi.ajp.2011.168.10.1021

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October 2011

Response to Presidential Address

John M. Oldham, M.D.

Pages:1026–1028
Published Online:1 October 2011

https://doi.org/10.1176/appi.ajp.2011.168.10.1026

First Page
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October 2011

Carol A. Bernstein, 137th President, 2010–2011

Carolyn B. Robinowitz, M.D.

Pages:1029–1030
Published Online:1 October 2011

https://doi.org/10.1176/appi.ajp.2011.168.10.1029

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Introspection

October 2011

My Father's Shoes

Hochang B. Lee, M.D.

Pages:1031–1032
Published Online:1 October 2011

https://doi.org/10.1176/appi.ajp.2011.11050757

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Images in Psychiatry

October 2011

A 200th Anniversary of Academic Psychiatry

Holger Steinberg, M.D.

Pages:1033–1034
Published Online:1 October 2011

https://doi.org/10.1176/appi.ajp.2011.11010024

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Treatment in Psychiatry

October 2011

T₃ Augmentation in Major Depressive Disorder: Safety Considerations

Lisa J. Rosenthal, M.D.,
Whitney S. Goldner, M.D., and
John P. O'Reardon, M.D.

Pages:1035–1040
Published Online:1 October 2011

https://doi.org/10.1176/appi.ajp.2011.10030402

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Reviews and Overviews

October 2011

A Critical Review of the First 10 Years of Candidate Gene-by-Environment Interaction Research in Psychiatry

Laramie E. Duncan, Ph.D., and
Matthew C. Keller, Ph.D.

Pages:1041–1049
Published Online:1 October 2011

https://doi.org/10.1176/appi.ajp.2011.11020191

Abstract
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Research on how interactions between candidate genes and environmental factors influence psychiatric illnesses has generated enthusiasm but not many replicable findings. The authors discovered that the more closely a replication study matched the original ...

Articles

October 2011

Treatment of Suicide Attempters With Bipolar Disorder: A Randomized Clinical Trial Comparing Lithium and Valproate in the Prevention of Suicidal Behavior

Maria A. Oquendo, M.D.,
Hanga C. Galfalvy, Ph.D.,
Dianne Currier, Ph.D.,
Michael F. Grunebaum, M.D.,
Leo Sher, M.D.,
Gregory M. Sullivan, M.D.,
Ainsley K. Burke, Ph.D.,
Jill Harkavy-Friedman, Ph.D.,
M. Elizabeth Sublette, M.D., Ph.D.,
Ramin V. Parsey, M.D., Ph.D., and
J. John Mann, M.D.

Pages:1050–1056
Published Online:1 October 2011

https://doi.org/10.1176/appi.ajp.2011.11010163

Abstract
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A 2.5-year randomized trial of lithium versus valproate treatment for patients with bipolar disorder who had made a previous suicide attempt found no difference in subsequent attempts between the two treatment groups.

October 2011

National Trends in the Antipsychotic Treatment of Psychiatric Outpatients With Anxiety Disorders

Jonathan S. Comer, Ph.D.,
Ramin Mojtabai, M.D., Ph.D., M.P.H., and
Mark Olfson, M.D., M.P.H.

Pages:1057–1065
Published Online:1 October 2011

https://doi.org/10.1176/appi.ajp.2011.11010087

Abstract
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Prescription of antipsychotic medications during visits for anxiety disorders doubled between 1996 and 2007 among office-based psychiatrists, from 10.6% to 21.3% of visits. The nationwide data demonstrate increases for comorbid FDA-approved indications, ...

October 2011

Cognitive-Behavioral Therapy for Depression in Parkinson's Disease: A Randomized, Controlled Trial

Roseanne D. Dobkin, Ph.D.,
Matthew Menza, M.D.,
Lesley A. Allen, Ph.D.,
Michael A. Gara, Ph.D.,
Margery H. Mark, M.D.,
Jade Tiu, Psy.M.,
Karina L. Bienfait, Ph.D., and
Jill Friedman, Ph.D.

Pages:1066–1074
Published Online:1 October 2011

https://doi.org/10.1176/appi.ajp.2011.10111669

Abstract
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Depression scores declined more for depressed patients with Parkinson's disease who received 10 weeks of CBT plus clinical monitoring than for those who received clinical monitoring only. The study of 80 patients also showed greater improvements in ...

October 2011

fMRI Correlates of White Matter Hyperintensities in Late-Life Depression

Howard J. Aizenstein, M.D., Ph.D.,
Carmen Andreescu, M.D.,
Kathryn L. Edelman, B.A.,
Jennifer L. Cochran, Ph.D.,
Julie Price, Ph.D.,
Meryl A. Butters, Ph.D.,
Jordan Karp, M.D.,
Meenal Patel, B.S., and
Charles F. Reynolds, M.D.

Pages:1075–1082
Published Online:1 October 2011

https://doi.org/10.1176/appi.ajp.2011.10060853

Abstract
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Brain activation differences during emotional processing between elderly patients with and without major depressive disorder were greater for depressed patients with more white matter lesions.

October 2011

Association of the Alzheimer's Gene SORL1 With Hippocampal Volume in Young, Healthy Adults

Janita Bralten, M.S.,
Alejandro Arias-Vásquez, Ph.D.,
Remco Makkinje, B.S.,
Joris A. Veltman, Ph.D.,
Han G. Brunner, M.D., Ph.D.,
Guillén Fernández, M.D., Ph.D.,
Mark Rijpkema, Ph.D., and
Barbara Franke, Ph.D.

Pages:1083–1089
Published Online:1 October 2011

https://doi.org/10.1176/appi.ajp.2011.10101509

Abstract
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Variants in SORL1 have previously been established to increase the risk for Alzheimer's disease. The findings from this study that multiple variants in SORL1 contributed to decreased hippocampal size suggest a biological basis for this effect and thus ...

October 2011

Effects of the Circadian Rhythm Gene Period 1 (Per1) on Psychosocial Stress-Induced Alcohol Drinking

Li Dong, Ph.D.,
Ainhoa Bilbao, Ph.D.,
Manfred Laucht, Ph.D.,
Richard Henriksson, Ph.D.,
Tatjana Yakovleva, Ph.D.,
Monika Ridinger, M.D.,
Sylvane Desrivieres, Ph.D.,
Toni-Kim Clarke, Ph.D.,
Anbarasu Lourdusamy, Ph.D.,
Michael N. Smolka, M.D.,
Sven Cichon, Ph.D.,
Dorothea Blomeyer, Ph.D.,
Jens Treutlein, Ph.D.,
Stephanie Perreau-Lenz, Ph.D.,
Stephanie Witt, Ph.D.,
Fernando Leonardi-Essmann, M.Sc.,
Norbert Wodarz, M.D.,
Peter Zill, M.D.,
Michael Soyka, M.D.,
Urs Albrecht, Ph.D.,
Marcella Rietschel, M.D.,
Mark Lathrop, Ph.D.,
Georgy Bakalkin, Ph.D.,
Rainer Spanagel, Ph.D., and
Gunter Schumann, M.D.

Pages:1090–1098
Published Online:1 October 2011

https://doi.org/10.1176/appi.ajp.2011.10111579

Abstract
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Converging evidence from an animal model, two human populations (one at risk and the other with confirmed alcoholism), and molecular studies on the human gene itself has provided a chain of support for the hypothesis of a role for the Per1 gene and its ...

October 2011

Nitric Oxide Synthase Genotype Modulation of Impulsivity and Ventral Striatal Activity in Adult ADHD Patients and Healthy Comparison Subjects

Martine Hoogman, M.Sc.,
Esther Aarts, Ph.D.,
Marcel Zwiers, Ph.D.,
Dorine Slaats-Willemse, Ph.D.,
Marlies Naber, BA.Sc.,
Marten Onnink, M.Sc.,
Roshan Cools, Ph.D.,
Cornelis Kan, Ph.D., M.D.,
Jan Buitelaar, Ph.D., M.D., and
Barbara Franke, Ph.D.

Pages:1099–1106
Published Online:1 October 2011

https://doi.org/10.1176/appi.ajp.2011.10101446

Abstract
Full text
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Since ADHD and, in particular, impulsivity are related to decreased ventral striatal activity, it was hypothesized that the NOS1 genotype itself might also be related to decreased ventral striatal activity. However, the authors found instead that NOS1 ...

October 2011

Interaction of FKBP5 Gene Variants and Adverse Life Events in Predicting Depression Onset: Results From a 10-Year Prospective Community Study

Petra Zimmermann, Ph.D.,
Tanja Brückl, Ph.D.,
Agnes Nocon, Ph.D.,
Hildegard Pfister, M.Sc.,
Elisabeth B. Binder, M.D., Ph.D.,
Manfred Uhr, M.D., Ph.D.,
Roselind Lieb, Ph.D.,
Terrie E. Moffitt, Ph.D.,
Avshalom Caspi, Ph.D.,
Florian Holsboer, M.D., Ph.D., and
Marcus Ising, Ph.D.

Pages:1107–1116
Published Online:1 October 2011

https://doi.org/10.1176/appi.ajp.2011.10111577

Abstract
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The FKBP5 gene modulates function of glucocorticoid receptors and has been frequently studied as a risk factor for depression and suicidality. This long-term study found a gene-by-environment effect for minor variants in the gene in the presence of trauma ...

Letters to the Editor

October 2011

How Dosing Might Influence the Conclusion in an Antipsychotic Polypharmacy Effectiveness Trial

Lone Baandrup, M.D., Ph.D.

Page:1117
Published Online:1 October 2011

https://doi.org/10.1176/appi.ajp.2011.11050751

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October 2011

Response to Baandrup Letter

Nancy H. Covell, Ph.D.,

Joseph P. McEvoy, M.D.,

T. Scott Stroup, M.D., M.P.H.,

Nina R. Schooler, Ph.D., and

Susan M. Essock, Ph.D.

Page:1117
Published Online:1 October 2011

https://doi.org/10.1176/appi.ajp.2011.11050751r

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October 2011

Preventing Pain Medication Dependence

Patrick J. Lustman, Ph.D.,
Dragan M. Svrakic, M.D., and
Kenneth E. Freedland, Ph.D.

Page:1118
Published Online:1 October 2011

https://doi.org/10.1176/appi.ajp.2011.11060869

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October 2011

Response to Lustman et al. Letter

Carrie L. Dodrill, Ph.D.,
Drew A. Helmer, M.D., and
Thomas R. Kosten, M.D.

Pages:1118–1119
Published Online:1 October 2011

https://doi.org/10.1176/appi.ajp.2011.11060869r

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October 2011

Psychosis Associated With Synthetic Cannabinoid Agonists: A Case Series

Donald Hurst, M.D.,
George Loeffler, M.D., and
Robert McLay, M.D., Ph.D.

Page:1119
Published Online:1 October 2011

https://doi.org/10.1176/appi.ajp.2011.11010176

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October 2011

Clozapine Rechallenge After Excluding the High-Risk Clozapine-Induced Agranulocytosis Genotype of HLA-DQB1 6672G>C

Curtis McKnight, M.D.,
Hossam Guirgis, M.D., and
Nick Votolato, M.D.

Page:1120
Published Online:1 October 2011

https://doi.org/10.1176/appi.ajp.2011.11020202

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October 2011

Eating Disorder as a Psychiatric Onset of Juvenile Huntington's Disease

Sara Marconi, M.D.,
Giovanni Rizzo, M.D., Ph.D.,
Sabina Capellari, M.D., Ph.D.,
Cesa Scaglione, M.D., Ph.D.,
Pietro Cortelli, M.D., Ph.D.,
Paolo Martinelli, M.D., Ph.D., and
Sara Bonazza, M.D.

Pages:1120–1121
Published Online:1 October 2011

https://doi.org/10.1176/appi.ajp.2011.11020312

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Book Forum

October 2011

The Conceptual Evolution of DSM-5

Mark Zimmerman, M.D.

Page:1122
Published Online:1 October 2011

https://doi.org/10.1176/appi.ajp.2011.11030343

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October 2011

Integrative Neuroscience and Personalized Medicine

Mauricio Tohen, M.D., Dr.PH., M.B.A.

Pages:1123–1124
Published Online:1 October 2011

https://doi.org/10.1176/appi.ajp.2011.11020200

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October 2011

Mental Health Care in the College Community

Richard Kadison, M.D.

Page:1123
Published Online:1 October 2011

https://doi.org/10.1176/appi.ajp.2011.11040614

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October 2011

The Risks of Prescription Drugs

Steven L. Dubovsky, M.D.

Pages:1124–1125
Published Online:1 October 2011

https://doi.org/10.1176/appi.ajp.2011.11040584

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Books Received

October 2011

Page:1126
Published Online:1 October 2011

https://doi.org/10.1176/appi.ajp.2011.168.10.1126

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