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Dr. Walters is supported by a JMAS Sim Fellowship from the Royal College of Physicians of Edinburgh. This study was conducted using the UK Biobank resource. UK Biobank was established by the Wellcome Trust, Medical Research Council, Department of Health, Scottish Government, and Northwest Regional Development Agency. UK Biobank has received funding from the Welsh Assembly Government and the British Heart Foundation. Data collection was funded by UK Biobank. The work at Cardiff University was supported by Medical Research Council (MRC) Centre (grant MR/L010305/1) and by a program grant (grant G0800509). The CLOZUK sample was genotyped with funding from the European Union’s Seventh Framework Programme for research, technological development, and demonstration (grant 279227) (CRESTAR Consortium).