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Dyskinesia and psychosis in a patient following baclofen withdrawal

Published Online:https://doi.org/10.1176/ajp.141.5.692

A paraplegic man with no history of psychiatric illness developed psychosis and dyskinesia following abrupt withdrawal of baclofen; the symptoms resolved 72 hours after resumption of the drug. The psychosis and dyskinesia may have been a manifestation of baclofen's alteration of cerebral dopaminergic mechanisms.

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