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Effect of imipramine on depression and immune status in a sample of men with HIV infection

Published Online:https://doi.org/10.1176/ajp.147.4.495

Eleven men with major depression and human immunodeficiency virus (HIV) infection underwent an open trial of imipramine. Eight of nine (89%) who completed 12 weeks responded. The mean decline in T4 cells from baseline was 100 at week 12 and 16 at week 26. No major exacerbations of HIV infection occurred.

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