TRH-induced TSH response in healthy volunteers: relationship to psychiatric history
Abstract
The authors measured thyroid-stimulating hormone (TSH) response to thyrotropin-releasing hormone in 32 healthy volunteers who had never sought or received psychiatric treatment. Nine (28%) had a family or personal history of depression or alcoholism. Five of these nine subjects and one of 22 subjects without such a history showed TSH blunting (TSH data were not available for one subject). This difference was statistically highly significant. Although there were sex differences in TSH response, TSH blunting occurred most frequently in men with a family or personal history of depression or alcoholism. The fault may have utility as a marker of past episodes or as a true marker of trait.
Access content
To read the fulltext, please use one of the options below to sign in or purchase access.- Personal login
- Institutional Login
- Sign in via OpenAthens
- Register for access
-
Please login/register if you wish to pair your device and check access availability.
Not a subscriber?
PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.
Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).
