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Serotoninergic agents in the treatment of isolated sleep paralysis

Published Online:https://doi.org/10.1176/ajp.139.9.1202

The authors report three cases of isolated sleep paralysis controlled by L-tryptophan with or without amitriptyline. Both agents increase CNS 5-hydroxytryptamine availability, whereas imipramine, which was ineffective in the one case in which it was tried, affects predominantly norepinephrine reuptake.

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