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Schizophrenic-Like Reactions and Affective Psychoses Associated with Temporal Lobe Epilepsy: Etiological Factors

Published Online:https://doi.org/10.1176/ajp.126.3.400

A controlled comparative investigation showed that temporal lobe epilepsy of the dominant hemisphere predisposes to psychotic manifestations; epilepsy of the non-dominant temporal lobe is associated with manic-depressive psychotic reactions and epilepsy of the dominant temporal lobe with schizophrenic-like psychotic reactions. Also, the presence of psychomotor seizures and frequent temporal seizures is inversely correlated with psychosis; and in epileptic psychoses, periodicity is correlated with minimal brain damage and chronicity with maximal brain damage.

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