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AGRANULOCYTOSIS IN PATIENTS TREATED WITH THORAZINE

Report of a Fatal Case
Published Online:https://doi.org/10.1176/ajp.113.11.991

This case demonstrates two points to be remembered with Thorazine; namely, that the dosage does not have to be high to produce agranulocytosis in susceptible patients, and that even when Thorazine has been withdrawn and replaced by energetic treatment and agranulocytosis hematologically resolved, the clinical course may be fatal.

We are not sure what part had been played by the patient's pulmonary emphysema and cerebral aneurysm in her clinical condition.

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