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American Journal of Psychiatry

Volume 172, Issue 6

June 2015

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Editorials

June 2015

Alcohol Use Disorders: Tracts, Twins, and Trajectories

George F. Koob, Ph.D.

Pages:499–501
Published Online:18 May 2015

https://doi.org/10.1176/appi.ajp.2015.15020240

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June 2015

Attention Must Be Paid: The Association of Plasma Clozapine/NDMC Ratio With Working Memory

Herbert Y. Meltzer, M.D.

Pages:502–504
Published Online:1 June 2015

https://doi.org/10.1176/appi.ajp.2015.15030338

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June 2015

The Role of Stimulants in Late-Life Depression

J. Craig Nelson, M.D.

Pages:505–507
Published Online:1 June 2015

https://doi.org/10.1176/appi.ajp.2015.15030356

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June 2015

Parents and Genes and Their Effects on Alcohol, Drugs, and Crime in Triparental Families

Anita Thapar, M.D., Ph.D.

Pages:508–509
Published Online:1 June 2015

https://doi.org/10.1176/appi.ajp.2015.15020263

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Introspection

June 2015

On Being Chronically Ill

Mark D. Rego, M.D.

Pages:510–511
Published Online:1 June 2015

https://doi.org/10.1176/appi.ajp.2015.15020165

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Clinical Case Conference

June 2015

Psychiatric Care During Hepatitis C Treatment: The Changing Role of Psychiatrists in the Era of Direct-Acting Antivirals

Sanjeev Sockalingam, M.D.,
Kathleen Sheehan, M.D., D.Phil.,
Jordan J. Feld, M.D., M.P.H.,
Hemant Shah, M.D., M.Sc.C.H. (H.P.T.E.)

Pages:512–516
Published Online:1 June 2015

https://doi.org/10.1176/appi.ajp.2015.14081041

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Images in Psychiatry

June 2015

The Stone That Mourns Its Victims: Haiti Still Recovering From Its Injuries and Traumas 5 Years After the 2010 Earthquake

Jude Mary Cénat, Ph.D.,
Patricia Eid, M.Ps.,
Daniel Derivois, Ph.D.,
Martine Hébert, Ph.D.,
Lewis Ampidu Clorméus, Ph.D.

Pages:517–518
Published Online:1 June 2015

https://doi.org/10.1176/appi.ajp.2015.15010078

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Review and Overviews

June 2015

CBT for Adolescents With Anxiety: Mature Yet Still Developing

Philip C. Kendall, Ph.D.,
Jeremy S. Peterman, M.A.

Pages:519–530
Published Online:1 June 2015

https://doi.org/10.1176/appi.ajp.2015.14081061

Abstract
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Anxiety disorders are common in adolescents (ages 12 to 18) and contribute to a range of impairments. There has been speculation that adolescents with anxiety are at risk for being treatment nonresponders. In this review, the authors examine the efficacy ...

Articles

June 2015

Brain Development in Heavy-Drinking Adolescents

Lindsay M. Squeglia, Ph.D.,
Susan F. Tapert, Ph.D.,
Edith V. Sullivan, Ph.D.,
Joanna Jacobus, Ph.D.,
M.J. Meloy, Ph.D.,
Torsten Rohlfing, Ph.D.,
Adolf Pfefferbaum, M.D.

Pages:531–542
Published Online:18 May 2015

https://doi.org/10.1176/appi.ajp.2015.14101249

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Objective:Heavy alcohol use during adolescence may alter the trajectory of normal brain development. The authors measured within-subject changes in regional brain morphometry over longer intervals and in larger samples of adolescents than previously ...

June 2015

Association of Protein Phosphatase PPM1G With Alcohol Use Disorder and Brain Activity During Behavioral Control in a Genome-Wide Methylation Analysis

Pages:543–552
Published Online:18 May 2015

https://doi.org/10.1176/appi.ajp.2014.14030382

Abstract
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Objective:The genetic component of alcohol use disorder is substantial, but monozygotic twin discordance indicates a role for nonheritable differences that could be mediated by epigenetics. Despite growing evidence associating epigenetics and psychiatric ...

June 2015

Triparental Families: A New Genetic-Epidemiological Design Applied to Drug Abuse, Alcohol Use Disorders, and Criminal Behavior in a Swedish National Sample

Kenneth S. Kendler, M.D.,
Henrik Ohlsson, Ph.D.,
Jan Sundquist, M.D., Ph.D.,
Kristina Sundquist, M.D., Ph.D.

Pages:553–560
Published Online:20 February 2015

https://doi.org/10.1176/appi.ajp.2014.14091127

Abstract
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Objective:The authors sought to clarify the sources of parent-offspring resemblance for drug abuse, alcohol use disorders, and criminal behavior, using a novel genetic-epidemiological design.Method:Using national registries, the authors identified rates ...

June 2015

Citalopram, Methylphenidate, or Their Combination in Geriatric Depression: A Randomized, Double-Blind, Placebo-Controlled Trial

Helen Lavretsky, M.D.,
Michelle Reinlieb, Ph.D.,
Natalie St. Cyr, M.A.,
Prabha Siddarth, Ph.D.,
Linda M. Ercoli, Ph.D.,
Damla Senturk, Ph.D.

Pages:561–569
Published Online:13 February 2015

https://doi.org/10.1176/appi.ajp.2014.14070889

Abstract
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Objective:The authors evaluated the potential of methylphenidate to improve antidepressant response to citalopram, as assessed by clinical and cognitive outcomes, in elderly depressed patients.Method:The authors conducted a 16-week randomized double-blind ...

June 2015

Cerebral Small Vessel Disease and Association With Higher Incidence of Depressive Symptoms in a General Elderly Population: The AGES-Reykjavik Study

Thomas T. van Sloten, M.D.,
Sigurdur Sigurdsson, M.Sc.,
Mark A. van Buchem, M.D., Ph.D.,
Caroline L. Phillips, M.S.,
Palmi V. Jonsson, M.D.,
Jie Ding, Ph.D.,
Miranda T. Schram, Ph.D.,
Tamara B. Harris, M.D., M.S.,
Vilmundur Gudnason, M.D., Ph.D.,
Lenore J. Launer, Ph.D.

Pages:570–578
Published Online:3 March 2015

https://doi.org/10.1176/appi.ajp.2014.14050578

Abstract
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Objective:The vascular depression hypothesis postulates that cerebral small vessel disease (CSVD) leads to depressive symptoms by disruption of brain structures involved in mood regulation. However, longitudinal data on the association between CSVD and ...

June 2015

Prediction of Working Memory Performance in Schizophrenia by Plasma Ratio of Clozapine to N-Desmethylclozapine

Tarek K. Rajji, M.D.,
Benoit H. Mulsant, M.D., M.S.
Simon Davies, D.M., M.B.B.S.,
Sawsan M. Kalache, M.D.,
Christopher Tsoutsoulas, B.Sc.(Hons),
Bruce G. Pollock, M.D., Ph.D.,
Gary Remington, M.D., Ph.D.

Pages:579–585
Published Online:10 April 2015

https://doi.org/10.1176/appi.ajp.2015.14050673

Abstract
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Objective:Clozapine’s potent antagonism of muscarinic M₁ receptors is thought to worsen working memory deficits associated with schizophrenia. In contrast, its major metabolite, N-desmethylclozapine (NDMC), is thought to enhance working memory via its M₁ ...

Letters to the Editor

June 2015

Monotherapy Antidepressant Treatment is Not Associated With Mania in Bipolar I Disorder

Michael J. Ostacher, M.D., M.P.H., M.M.Sc.,
Roy H. Perlis, M.D., M.Sc.,
John Geddes, M.D., F.R.C.Psych.

Page:586
Published Online:1 June 2015

https://doi.org/10.1176/appi.ajp.2015.14111443

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June 2015

Response to Ostacher et al.

Mikael Landén, M.D., Ph.D.,
Alexander Viktorin, M.Sc.

Pages:586–587
Published Online:1 June 2015

https://doi.org/10.1176/appi.ajp.2015.14111443r

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June 2015

Evidence-Based Medicine and Clinical Expertise

Michael Saraga, M.D.

Page:587
Published Online:1 June 2015

https://doi.org/10.1176/appi.ajp.2015.14121589

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June 2015

Response to Saraga

Delbert G. Robinson, M.D.,
Nina R. Schooler, Ph.D.,
John M. Kane, M.D.

Page:588
Published Online:1 June 2015

https://doi.org/10.1176/appi.ajp.2015.14121589r

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Book Forum

June 2015

Transference-Focused Psychotherapy for Borderline Personality Disorder: A Clinical Guide

Robert E. Feinstein, M.D.

Pages:589–590
Published Online:1 June 2015

https://doi.org/10.1176/appi.ajp.2015.15020158

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June 2015

Serving the Amish: A Cultural Guide for Professionals

Alison M. Heru, M.D.

Pages:590–591
Published Online:1 June 2015

https://doi.org/10.1176/appi.ajp.2014.14121522

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Books Received

June 2015

Page:592
Published Online:1 June 2015

https://doi.org/10.1176/appi.ajp.2015.1726books

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