Genome-Wide Association Study of Suicide Attempts in Mood Disorder Patients
- Roy H. Perlis,
M.D., M.Sc. , - Jie Huang,
M.D., M.S., M.P.H. , - Shaun Purcell,
Ph.D. , - Maurizio Fava,
M.D. , - A. John Rush,
M.D. , - Patrick F. Sullivan,
M.D. , - Steven P. Hamilton,
M.D., Ph.D. , - Francis J. McMahon,
M.D. , - Thomas Schulze,
M.D. , - James B. Potash,
M.D., M.P.H. , - Peter P. Zandi,
Ph.D. , - Virginia L. Willour,
Ph.D. , - Brenda W. Penninx,
Ph.D., M.D. , - Dorret I. Boomsma,
Ph.D. , - Nicole Vogelzangs,
Ph.D. , - Christel M. Middeldorp,
M.D., Ph.D. , - Marcella Rietschel,
M.D. , - Markus Nöthen,
Ph.D. , - Sven Cichon,
Ph.D. , - Hugh Gurling,
M.D., M.Phil. , - Nick Bass,
M.D. , - Andrew McQuillin,
Ph.D. , - Marian Hamshere,
Ph.D. , - Wellcome Trust Case Control Consortium Bipolar Disorder Group,
- Nick Craddock,
M.D., Ph.D. , - Pamela Sklar,
M.D., Ph.D. , and - Jordan W. Smoller,
M.D., Sc.D.
From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom.
From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom.
From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom.
From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom.
From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom.
From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom.
From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom.
From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom.
From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom.
From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom.
From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom.
From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom.
From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom.
From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom.
From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom.
From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom.
From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom.
From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom.
From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom.
From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom.
From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom.
From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom.
From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom.
From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom.
From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom.
From the Department of Psychiatry, Depression and Bipolar Clinic and Research Programs, Massachusetts General Hospital, Boston; the Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston; the Duke-National University of Singapore Graduate Medical School, Singapore; the Departments of Genetics, Psychiatry, and Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the University of California at San Francisco, San Francisco; the Genetic Basis of Mood and Anxiety Disorders Division, National Institute of Mental Health, Bethesda, Md.; the Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore; the Departments of Psychiatry and Biological Psychology, Vrije Universiteit University Medical Center, Amsterdam; the Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany; the Department of Psychiatry and Institute of Human Genetics, University of Bonn, Bonn, Germany; the Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany; the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany; the Department of Molecular Psychiatry, University College London Medical School, London; and the Department of Psychological Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom.
Supplemental Material
ajp_167_12_1499_01.pdf (3 MB)
ajp_167_12_1499_02.pdf (3 MB)
ajp_167_12_1499_03.pdf (395 KB)
ajp_167_12_1499_04.pdf (333 KB)
ajp_167_12_1499_05.pdf (19 KB)
ajp_167_12_1499_06.pdf (558 KB)
ajp_167_12_1499_07.pdf (503 KB)
ajp_167_12_1499_08.pdf (1 MB)
ajp_167_12_1499_09.pdf (14 KB)