Association of Mouse Dlg4 (PSD-95) Gene Deletion and Human DLG4 Gene Variation With Phenotypes Relevant to Autism Spectrum Disorders and Williams' Syndrome
- Michael Feyder,
B.S. , - Rose-Marie Karlsson,
Ph.D. , - Poonam Mathur,
B.S. , - Matthew Lyman,
B.S. , - Roland Bock,
M.Sc. , - Reza Momenan,
Ph.D. , - Jeeva Munasinghe,
Ph.D. , - Maria Luisa Scattoni,
Ph.D. , - Jessica Ihne,
B.S. , - Marguerite Camp,
Ph.D. , - Carolyn Graybeal,
B.A. , - Douglas Strathdee,
Ph.D. , - Alison Begg,
Ph.D. , - Veronica A. Alvarez,
Ph.D. , - Peter Kirsch,
Ph.D. , - Marcella Rietschel,
M.D. , - Sven Cichon,
Ph.D. , - Henrik Walter,
M.D., Ph.D. , - Andreas Meyer-Lindenberg,
M.D., Ph.D. , - Seth G.N. Grant,
B.Sc., M.B.B.S. , and - Andrew Holmes,
Ph.D.
From the Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse (NIAAA); Section on Synaptic Pharmacology and Section on Neuronal Structure, Laboratory for Integrative Neuroscience, NIAAA; Section on Brain Electrophysiology and Imaging, Laboratory of Clinical and Translational Studies, NIAAA; National Institute of Neurological Disorders and Stroke; Section of Neurotoxicology and Neuroendocrinology, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanit…, Rome; Wellcome Trust Sanger Institute, Well-come Trust Genome Campus, Hinxton, U.K.; Centre for Neuroscience, University of Edinburgh, Edinburgh; Department of Psychiatry and Psychotherapy and Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany; Department of Genomics, Life and Brain Center, and Institute of Human Genetics, and Division of Medical Psychology, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
From the Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse (NIAAA); Section on Synaptic Pharmacology and Section on Neuronal Structure, Laboratory for Integrative Neuroscience, NIAAA; Section on Brain Electrophysiology and Imaging, Laboratory of Clinical and Translational Studies, NIAAA; National Institute of Neurological Disorders and Stroke; Section of Neurotoxicology and Neuroendocrinology, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanit…, Rome; Wellcome Trust Sanger Institute, Well-come Trust Genome Campus, Hinxton, U.K.; Centre for Neuroscience, University of Edinburgh, Edinburgh; Department of Psychiatry and Psychotherapy and Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany; Department of Genomics, Life and Brain Center, and Institute of Human Genetics, and Division of Medical Psychology, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
From the Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse (NIAAA); Section on Synaptic Pharmacology and Section on Neuronal Structure, Laboratory for Integrative Neuroscience, NIAAA; Section on Brain Electrophysiology and Imaging, Laboratory of Clinical and Translational Studies, NIAAA; National Institute of Neurological Disorders and Stroke; Section of Neurotoxicology and Neuroendocrinology, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanit…, Rome; Wellcome Trust Sanger Institute, Well-come Trust Genome Campus, Hinxton, U.K.; Centre for Neuroscience, University of Edinburgh, Edinburgh; Department of Psychiatry and Psychotherapy and Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany; Department of Genomics, Life and Brain Center, and Institute of Human Genetics, and Division of Medical Psychology, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
From the Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse (NIAAA); Section on Synaptic Pharmacology and Section on Neuronal Structure, Laboratory for Integrative Neuroscience, NIAAA; Section on Brain Electrophysiology and Imaging, Laboratory of Clinical and Translational Studies, NIAAA; National Institute of Neurological Disorders and Stroke; Section of Neurotoxicology and Neuroendocrinology, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanit…, Rome; Wellcome Trust Sanger Institute, Well-come Trust Genome Campus, Hinxton, U.K.; Centre for Neuroscience, University of Edinburgh, Edinburgh; Department of Psychiatry and Psychotherapy and Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany; Department of Genomics, Life and Brain Center, and Institute of Human Genetics, and Division of Medical Psychology, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
From the Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse (NIAAA); Section on Synaptic Pharmacology and Section on Neuronal Structure, Laboratory for Integrative Neuroscience, NIAAA; Section on Brain Electrophysiology and Imaging, Laboratory of Clinical and Translational Studies, NIAAA; National Institute of Neurological Disorders and Stroke; Section of Neurotoxicology and Neuroendocrinology, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanit…, Rome; Wellcome Trust Sanger Institute, Well-come Trust Genome Campus, Hinxton, U.K.; Centre for Neuroscience, University of Edinburgh, Edinburgh; Department of Psychiatry and Psychotherapy and Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany; Department of Genomics, Life and Brain Center, and Institute of Human Genetics, and Division of Medical Psychology, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
From the Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse (NIAAA); Section on Synaptic Pharmacology and Section on Neuronal Structure, Laboratory for Integrative Neuroscience, NIAAA; Section on Brain Electrophysiology and Imaging, Laboratory of Clinical and Translational Studies, NIAAA; National Institute of Neurological Disorders and Stroke; Section of Neurotoxicology and Neuroendocrinology, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanit…, Rome; Wellcome Trust Sanger Institute, Well-come Trust Genome Campus, Hinxton, U.K.; Centre for Neuroscience, University of Edinburgh, Edinburgh; Department of Psychiatry and Psychotherapy and Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany; Department of Genomics, Life and Brain Center, and Institute of Human Genetics, and Division of Medical Psychology, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
From the Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse (NIAAA); Section on Synaptic Pharmacology and Section on Neuronal Structure, Laboratory for Integrative Neuroscience, NIAAA; Section on Brain Electrophysiology and Imaging, Laboratory of Clinical and Translational Studies, NIAAA; National Institute of Neurological Disorders and Stroke; Section of Neurotoxicology and Neuroendocrinology, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanit…, Rome; Wellcome Trust Sanger Institute, Well-come Trust Genome Campus, Hinxton, U.K.; Centre for Neuroscience, University of Edinburgh, Edinburgh; Department of Psychiatry and Psychotherapy and Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany; Department of Genomics, Life and Brain Center, and Institute of Human Genetics, and Division of Medical Psychology, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
From the Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse (NIAAA); Section on Synaptic Pharmacology and Section on Neuronal Structure, Laboratory for Integrative Neuroscience, NIAAA; Section on Brain Electrophysiology and Imaging, Laboratory of Clinical and Translational Studies, NIAAA; National Institute of Neurological Disorders and Stroke; Section of Neurotoxicology and Neuroendocrinology, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanit…, Rome; Wellcome Trust Sanger Institute, Well-come Trust Genome Campus, Hinxton, U.K.; Centre for Neuroscience, University of Edinburgh, Edinburgh; Department of Psychiatry and Psychotherapy and Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany; Department of Genomics, Life and Brain Center, and Institute of Human Genetics, and Division of Medical Psychology, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
From the Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse (NIAAA); Section on Synaptic Pharmacology and Section on Neuronal Structure, Laboratory for Integrative Neuroscience, NIAAA; Section on Brain Electrophysiology and Imaging, Laboratory of Clinical and Translational Studies, NIAAA; National Institute of Neurological Disorders and Stroke; Section of Neurotoxicology and Neuroendocrinology, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanit…, Rome; Wellcome Trust Sanger Institute, Well-come Trust Genome Campus, Hinxton, U.K.; Centre for Neuroscience, University of Edinburgh, Edinburgh; Department of Psychiatry and Psychotherapy and Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany; Department of Genomics, Life and Brain Center, and Institute of Human Genetics, and Division of Medical Psychology, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
From the Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse (NIAAA); Section on Synaptic Pharmacology and Section on Neuronal Structure, Laboratory for Integrative Neuroscience, NIAAA; Section on Brain Electrophysiology and Imaging, Laboratory of Clinical and Translational Studies, NIAAA; National Institute of Neurological Disorders and Stroke; Section of Neurotoxicology and Neuroendocrinology, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanit…, Rome; Wellcome Trust Sanger Institute, Well-come Trust Genome Campus, Hinxton, U.K.; Centre for Neuroscience, University of Edinburgh, Edinburgh; Department of Psychiatry and Psychotherapy and Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany; Department of Genomics, Life and Brain Center, and Institute of Human Genetics, and Division of Medical Psychology, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
From the Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse (NIAAA); Section on Synaptic Pharmacology and Section on Neuronal Structure, Laboratory for Integrative Neuroscience, NIAAA; Section on Brain Electrophysiology and Imaging, Laboratory of Clinical and Translational Studies, NIAAA; National Institute of Neurological Disorders and Stroke; Section of Neurotoxicology and Neuroendocrinology, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanit…, Rome; Wellcome Trust Sanger Institute, Well-come Trust Genome Campus, Hinxton, U.K.; Centre for Neuroscience, University of Edinburgh, Edinburgh; Department of Psychiatry and Psychotherapy and Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany; Department of Genomics, Life and Brain Center, and Institute of Human Genetics, and Division of Medical Psychology, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
From the Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse (NIAAA); Section on Synaptic Pharmacology and Section on Neuronal Structure, Laboratory for Integrative Neuroscience, NIAAA; Section on Brain Electrophysiology and Imaging, Laboratory of Clinical and Translational Studies, NIAAA; National Institute of Neurological Disorders and Stroke; Section of Neurotoxicology and Neuroendocrinology, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanit…, Rome; Wellcome Trust Sanger Institute, Well-come Trust Genome Campus, Hinxton, U.K.; Centre for Neuroscience, University of Edinburgh, Edinburgh; Department of Psychiatry and Psychotherapy and Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany; Department of Genomics, Life and Brain Center, and Institute of Human Genetics, and Division of Medical Psychology, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
From the Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse (NIAAA); Section on Synaptic Pharmacology and Section on Neuronal Structure, Laboratory for Integrative Neuroscience, NIAAA; Section on Brain Electrophysiology and Imaging, Laboratory of Clinical and Translational Studies, NIAAA; National Institute of Neurological Disorders and Stroke; Section of Neurotoxicology and Neuroendocrinology, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanit…, Rome; Wellcome Trust Sanger Institute, Well-come Trust Genome Campus, Hinxton, U.K.; Centre for Neuroscience, University of Edinburgh, Edinburgh; Department of Psychiatry and Psychotherapy and Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany; Department of Genomics, Life and Brain Center, and Institute of Human Genetics, and Division of Medical Psychology, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
From the Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse (NIAAA); Section on Synaptic Pharmacology and Section on Neuronal Structure, Laboratory for Integrative Neuroscience, NIAAA; Section on Brain Electrophysiology and Imaging, Laboratory of Clinical and Translational Studies, NIAAA; National Institute of Neurological Disorders and Stroke; Section of Neurotoxicology and Neuroendocrinology, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanit…, Rome; Wellcome Trust Sanger Institute, Well-come Trust Genome Campus, Hinxton, U.K.; Centre for Neuroscience, University of Edinburgh, Edinburgh; Department of Psychiatry and Psychotherapy and Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany; Department of Genomics, Life and Brain Center, and Institute of Human Genetics, and Division of Medical Psychology, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
From the Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse (NIAAA); Section on Synaptic Pharmacology and Section on Neuronal Structure, Laboratory for Integrative Neuroscience, NIAAA; Section on Brain Electrophysiology and Imaging, Laboratory of Clinical and Translational Studies, NIAAA; National Institute of Neurological Disorders and Stroke; Section of Neurotoxicology and Neuroendocrinology, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanit…, Rome; Wellcome Trust Sanger Institute, Well-come Trust Genome Campus, Hinxton, U.K.; Centre for Neuroscience, University of Edinburgh, Edinburgh; Department of Psychiatry and Psychotherapy and Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany; Department of Genomics, Life and Brain Center, and Institute of Human Genetics, and Division of Medical Psychology, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
From the Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse (NIAAA); Section on Synaptic Pharmacology and Section on Neuronal Structure, Laboratory for Integrative Neuroscience, NIAAA; Section on Brain Electrophysiology and Imaging, Laboratory of Clinical and Translational Studies, NIAAA; National Institute of Neurological Disorders and Stroke; Section of Neurotoxicology and Neuroendocrinology, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanit…, Rome; Wellcome Trust Sanger Institute, Well-come Trust Genome Campus, Hinxton, U.K.; Centre for Neuroscience, University of Edinburgh, Edinburgh; Department of Psychiatry and Psychotherapy and Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany; Department of Genomics, Life and Brain Center, and Institute of Human Genetics, and Division of Medical Psychology, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
From the Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse (NIAAA); Section on Synaptic Pharmacology and Section on Neuronal Structure, Laboratory for Integrative Neuroscience, NIAAA; Section on Brain Electrophysiology and Imaging, Laboratory of Clinical and Translational Studies, NIAAA; National Institute of Neurological Disorders and Stroke; Section of Neurotoxicology and Neuroendocrinology, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanit…, Rome; Wellcome Trust Sanger Institute, Well-come Trust Genome Campus, Hinxton, U.K.; Centre for Neuroscience, University of Edinburgh, Edinburgh; Department of Psychiatry and Psychotherapy and Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany; Department of Genomics, Life and Brain Center, and Institute of Human Genetics, and Division of Medical Psychology, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
From the Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse (NIAAA); Section on Synaptic Pharmacology and Section on Neuronal Structure, Laboratory for Integrative Neuroscience, NIAAA; Section on Brain Electrophysiology and Imaging, Laboratory of Clinical and Translational Studies, NIAAA; National Institute of Neurological Disorders and Stroke; Section of Neurotoxicology and Neuroendocrinology, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanit…, Rome; Wellcome Trust Sanger Institute, Well-come Trust Genome Campus, Hinxton, U.K.; Centre for Neuroscience, University of Edinburgh, Edinburgh; Department of Psychiatry and Psychotherapy and Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany; Department of Genomics, Life and Brain Center, and Institute of Human Genetics, and Division of Medical Psychology, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
From the Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse (NIAAA); Section on Synaptic Pharmacology and Section on Neuronal Structure, Laboratory for Integrative Neuroscience, NIAAA; Section on Brain Electrophysiology and Imaging, Laboratory of Clinical and Translational Studies, NIAAA; National Institute of Neurological Disorders and Stroke; Section of Neurotoxicology and Neuroendocrinology, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanit…, Rome; Wellcome Trust Sanger Institute, Well-come Trust Genome Campus, Hinxton, U.K.; Centre for Neuroscience, University of Edinburgh, Edinburgh; Department of Psychiatry and Psychotherapy and Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany; Department of Genomics, Life and Brain Center, and Institute of Human Genetics, and Division of Medical Psychology, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
From the Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse (NIAAA); Section on Synaptic Pharmacology and Section on Neuronal Structure, Laboratory for Integrative Neuroscience, NIAAA; Section on Brain Electrophysiology and Imaging, Laboratory of Clinical and Translational Studies, NIAAA; National Institute of Neurological Disorders and Stroke; Section of Neurotoxicology and Neuroendocrinology, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanit…, Rome; Wellcome Trust Sanger Institute, Well-come Trust Genome Campus, Hinxton, U.K.; Centre for Neuroscience, University of Edinburgh, Edinburgh; Department of Psychiatry and Psychotherapy and Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany; Department of Genomics, Life and Brain Center, and Institute of Human Genetics, and Division of Medical Psychology, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
From the Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse (NIAAA); Section on Synaptic Pharmacology and Section on Neuronal Structure, Laboratory for Integrative Neuroscience, NIAAA; Section on Brain Electrophysiology and Imaging, Laboratory of Clinical and Translational Studies, NIAAA; National Institute of Neurological Disorders and Stroke; Section of Neurotoxicology and Neuroendocrinology, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanit…, Rome; Wellcome Trust Sanger Institute, Well-come Trust Genome Campus, Hinxton, U.K.; Centre for Neuroscience, University of Edinburgh, Edinburgh; Department of Psychiatry and Psychotherapy and Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany; Department of Genomics, Life and Brain Center, and Institute of Human Genetics, and Division of Medical Psychology, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
Supplemental Material
ajp_167_12_1508_01.pdf (182 KB)
