CO2-Induced Panic Attacks: A Twin Study
Abstract
Objective: The authors investigated the role of genetic factors in 35% CO2-induced panic attacks.Method: Ninety twins recruited from general population were challenged with one-vital capacity inhalations of 35% CO2–65% O2. Probandwise concordance rates were calculated and rates compared for monozygotic and for dizygotic twins.Results: A significantly higher concordance was found for 35% CO2-induced panic attacks among monozygotic than dizygotic twins (55.6% versus 12.5%).Conclusions: These results suggest a relevant role of genetic factors in 35% CO2-induced panic attacks. Am J Psychiatry 1998; 155: 1184-1188