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An open trial of buspirone in obsessive-compulsive disorder

Published Online:https://doi.org/10.1176/ajp.145.10.1285

Of 14 patients with obsessive-compulsive disorder who entered an 8-week open trial of buspirone, none improved. The ineffectiveness of buspirone may shed light on the serotonergic hypothesis that has been proposed for this disorder.

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