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Alprazolam-induced manic episode in two patients with panic disorder

Published Online:https://doi.org/10.1176/ajp.143.5.652

Two patients treated with alprazolam for panic disorder and agoraphobia developed a manic episode. Two biological markers--shortened REM latency and nonsuppression on the dexamethasone suppression test-- suggested that both patients may have had an underlying affective disorder.

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