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Mania in two sisters with similar cerebellar disturbance

Published Online:https://doi.org/10.1176/ajp.142.9.1067

The authors describe two sisters who presented with a clinical picture consistent with mania. On further investigation, both had marked vermian and cerebellar cortical atrophy on CAT scans. Their mother also had a history suggestive of cerebellar disease. To the authors' knowledge, this is the first report of familial cerebellar disease with a clinical presentation of mania.

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