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Drug-induced rapid cycling: possible outcomes and management

Published Online:https://doi.org/10.1176/ajp.139.7.939

Rapid cycling of mood change induced by antidepressant drugs has recently emerged as a significant diagnostic and therapeutic problem. The author describes two additional cases. Cessation of treatment with the offending drug may leave the patient depressed, manic, or euthymic or in a state of continued rapid cycling. The author suggests an approach to management of this condition.

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