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Published Online:https://doi.org/10.1176/ajp.128.7.886

The dissociation produced in the auditory modality by a challenge with LSD can be quantitated by an instrumental perception test. Chlorpromazine can protect against this dissociation, and its efficacy can be measured by changes in auditory perception. The author describes this quantitative instrumental procedure. which is being developed into a "clinical yardstick" to measure dissociative mental dysfunction and illness, its intensity, and its response to therapy.

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