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Published Online:https://doi.org/10.1176/ajp.128.5.640

The authors describe a treatment of acute schizophrenia that combines drug therapy and psychotherapy. Patients are rapidly tranquilized by titrating dosage levels of phenothiazines administered every one or two hours against the patient's specific target symptoms to produce a tranquilized end point within six hours. Dosage levels are adjusted daily and chemotherapy is integrated with intensive social-systems intervention centered on the patient's real-life setting.

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