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Published Online:https://doi.org/10.1176/ajp.123.8.979

Reports in the literature on the Mecholyl test suggest that schizophrenics with a marked reaction to Mecholyl tend to be acute cases with good prognoses, demonstrating relatively good adjustment both preceding and during the psychosis. Schizophrenics with a mild Mecholyl reaction tend to be chronic and/or poor prognostic risks and manifest grossly inadequate premorbid as well as current functioning. The authors note conflicting evidence and identify the problem of test reliability as a primary source of ambiguous data.

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