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Published Online:https://doi.org/10.1176/ajp.119.4.369

1. Meprobamate in high dosage seems to be of value in the treatment of some chronic schizophrenic patients. If it is, it will exert its clinical effects in a relatively short time.

2. High dosage meprobamate seems efficacious in the facilitation of abreactive recall, even when the drug alone is not sufficient to bring about a clinical change.

3. The absence of side-effects other than transient somnolence makes meprobamate a relatively easy drug to use in a controlled inpatient setting.

4. Further studies seem indicated to evaluate adequately large dosage meprobamate therapy in schizophrenia.

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