Association Between Older Age and More Successful Aging: Critical Role of Resilience and Depression
Abstract
Objective
There is growing public health interest in understanding and promoting successful aging. While there has been some exciting empirical work on objective measures of physical health, relatively little published research combines physical, cognitive, and psychological assessments in large, randomly selected, community-based samples to assess self-rated successful aging.
Method
In the Successful AGing Evaluation (SAGE) study, the authors used a structured multicohort design to assess successful aging in 1,006 community-dwelling adults in San Diego County, ages 50–99 years, with oversampling of people over 80. A modified version of random-digit dialing was used to recruit subjects. Evaluations included a 25-minute telephone interview followed by a comprehensive mail-in survey of physical, cognitive, and psychological domains, including positive psychological traits and self-rated successful aging, scaled from 1 (lowest) to 10 (highest).
Results
The mean age of the respondents was 77.3 years. Their mean self-rating of successful aging was 8.2, and older age was associated with a higher rating, despite worsening physical and cognitive functioning. The best multiple regression model achieved, using all the potential correlates, accounted for 30% of the variance in the score for self-rated successful aging and included resilience, depression, physical functioning, and age (entering the regression model in that order).
Conclusions
Resilience and depression had significant associations with self-rated successful aging, with effects comparable in size to that for physical health. While no causality can be inferred from cross-sectional data, increasing resilience and reducing depression might have effects on successful aging as strong as that of reducing physical disability, suggesting an important role for psychiatry in promoting successful aging.
Presently there are about 40 million Americans over the age of 65, and by 2030 that number is expected to grow to 72 million (http://www.aoa.gov/AoARoot/Aging_Statistics/). The fastest-growing segment of the population is people over 80 (http://transgenerational.org/aging/demographics.htm). Traditionally, aging has been viewed as a period of progressive decline in physical, cognitive, and psychosocial functioning and consequently, a growing health care burden on the society. Many believe that aging is the top public health problem we face today (1), and the coming wave of aging baby boomers has been dubbed the “silver tsunami.” This negative view of old age contrasts with some exciting empirical research on older adults who continue to function well and are aging “successfully.” However, research advances in successful aging have been hampered by inconsistencies in operationalizing this construct—we found 29 different definitions of successful aging in 28 published studies on this topic (2). Many of these investigations have focused primarily on physical health. The most widely used definition of successful aging, employed in the pioneering MacArthur studies (3), is based on objective measures used by researchers to assess freedom from chronic disease and disability, along with high physical and cognitive functioning and social engagement. These studies are important because health care utilization and costs for older adults might be determined by such objective measures of successful aging. Moreover, this type of work may yield valuable information on modifiable factors, such as diet and exercise, to prevent or reduce physical disability.
At the same time, there is a need for a complementary line of research on subjectively determined successful aging, i.e., older adults’ self-rated successful aging, which also enables one to assess psychological functioning and overall health from a holistic perspective.
A few studies that included subjective perceptions on aging indicated that at least some older adults felt they were aging successfully despite having substantive physical challenges (5, 6). Self-assessments of successful aging have typically employed single items, e.g., questions such as, “How do you rate yourself on successful aging on a scale from 1 to 10?” or Likert-scale ratings of agreement with the statement “I am aging well” (7, 8). Qualitative studies of successful aging (9, 10) have shown that older adults center their definitions of successful aging on attitudinal factors, rather than merely physical health status.
The partial independence of self-rated successful aging from physical functioning suggests that successful aging should be conceptualized as a multidimensional construct. Pruchno et al. (5) found empirical support for a two-factor model of successful aging consisting of subjective and objective components. Doyle et al. (11) reported a multifactorial model of successful aging with interacting components including physical functioning and risk, activity, social engagement, and psychological traits such as confidence. Similarly, employing factor analysis in a convenience sample of postmenopausal women, our research group noted evidence supporting a model in which positive psychological traits seemed to interact with each individual's evaluation of her own physical and mental (but not cognitive) functioning, with the ultimate downstream outcome of importance to the individual’s successful aging (12). However, such models have not been examined in large, randomly selected community samples with overrepresentation of old-old people and multipronged assessments. Greater understanding of significant associations of successful aging is likely to help identify potentially modifiable characteristics in the individual’s behavior or environment.
The goal of the present investigation was to study self-rated successful aging along with several specific domains of aging and positive psychological traits in randomly selected, community-based middle-aged and older adults, with oversampling of those over age 80. Given the normative age-related declines in physical and cognitive functioning, we hypothesized that older age would be associated with worse physical and cognitive functioning and lower self-ratings of successful aging. On the basis of the literature (3, 5, 7, 8, 11, 12), we also hypothesized that self-rated successful aging would be positively related to physical, cognitive, and mental functioning and to positive psychological traits (13). Finally, we hypothesized that in a multivariate analysis, physical and mental (but not cognitive) functioning and positive psychological traits would predict self-ratings of successful aging, as in our previous investigation (12).
Method
Study Design and Recruitment
The Successful AGing Evaluation (SAGE) study used a structured multicohort design to recruit 1,300 community-dwelling residents of San Diego County ages 50–99 years, with an oversampling of people over age 80. The inclusion criteria were 1) age between 50 and 99 years, 2) a (landline) telephone in the home, 3) physical and mental ability to participate in a telephone interview and to complete a paper-and-pencil mail survey, 4) informed consent for study participation, and 5) English fluency. The exclusion criteria were 1) residence in a nursing home or need for daily skilled nursing care, 2) self-reported prior diagnosis of dementia, and 3) terminal illness or need for hospice care. The study was approved by the University of California, San Diego, Human Research Protections Program.
We planned to enroll 200 participants each in the 6th and 7th decades, 250 in the 8th decade, and 325 in the 9th and 10th decades, with approximately equal numbers of men and women in each decade and an ethnic distribution matching that in San Diego County. To identify the subjects, we contracted with California Survey Research Services (http://www.calsurvey.com/), which had lists of age-targeted samples in the county. These included 15,896 home telephone numbers along with the corresponding residents’ names and addresses. Participants were recruited by using list-assisted random-digit dialing procedures and telephone calling (5, 14) (Figure 1). We chose no more than one participant from any household. Members of our research team listened in to a subset of the telephone calls to ensure fidelity to the specified procedures. The age of the targeted sample (50 or older) minimized the loss of subjects who did not have a landline telephone or relied on mobile phones (15). California Survey Research Services had difficulty in recruiting the targeted number of people in their 90s who met all the inclusion and exclusion criteria. To make up for a smaller-than-desired number of people in their 90s (238 instead of 325), we recruited additional subjects in their 80s (411 instead of 325).
Telephone Interview
During a 25-minute structured telephone interview, the interviewers sought verbal consent from the potential participants, screened them to establish eligibility, and asked questions about their demographic characteristics, general health, depression and anxiety, and cognitive functioning. Depression was assessed with the two-item Personal Health Questionnaire, which consists of the first two questions of the 9-item version (16). Cognitive functioning was tested with the 12-item modified version of the Telephone Interview for Cognitive Status (17). This interview tests for deficits in orientation, memory, simple attention, working memory, and verbal episodic memory. Several studies have demonstrated that it is an effective screening instrument for cognitive impairment and is comparable to in-person neuropsychological screening (17, 18).
We met our goal of enrolling 1,300 participants who completed the telephone interview; 1,006 of them also completed the mail-in survey (described in the following). These 1,006 subjects were comparable in gender to, but slightly older than, the 294 participants who completed only the telephone interview; the mean ages were 77.3 years (SD=12.2) and 75.1 (13.6) years, respectively. The mail-in survey respondents were also more likely to be Caucasian: 81.0% versus 72.8%. The survey completion rates were lowest among the 50–59-year-old persons (67.2%) and highest among the 80–89-year-old individuals (84.4%). This may reflect a tendency for people in their 50s to be busier, as most of them still had active work lives.
A demographic comparison of the 1,006 respondents with census data on all adults age 18 or older living in the San Diego County (http://quickfacts.census.gov) revealed a higher proportion of Caucasians (81.0% versus 64.0%) and a higher proportion of individuals with a bachelor's degree or higher education (44.2% versus 34.1%) in the SAGE sample than in the county adult population. These differences likely relate to the fact that the SAGE sample was restricted to people age 50 or older who were fluent in English and had a home telephone.
Mail-In Survey
The survey questionnaire included detailed demographic questions and a number of rating scales and other measures. Several provided data for this study. Health-related quality of life and functioning were assessed with the Medical Outcomes Study 36-Item Short-Form Health Survey (Cronbach’s alpha=0.90) (19), which measures current physical and mental health functioning. Subjective cognitive functioning was tested with the Cognitive Failures Questionnaire (Cronbach’s alpha=0.96) (20). The severity of depressive symptoms was evaluated with the 9-item version of the Patient Health Questionnaire (Cronbach’s alpha=0.86–0.89) (16). Two instruments provided ratings of positive psychological constructs: the Life Orientation Test–Revised for optimism (Cronbach’s alpha=0.78) (21) and the 10-item version of the Connor-Davidson Resilience Scale (Cronbach’s alpha=0.85) (22). The participants were also asked to rate the extent to which they thought they had aged successfully, on a 10-point Likert-type scale ranging from 1 (least successful) to 10 (most successful) (7). The subjects were instructed to use their own conceptualization of successful aging rather than any investigator-defined construct.
Statistical Analyses
Our primary analyses included the 1,006 participants who completed both the telephone interview and the survey. We performed bivariate correlations between chronological age and physical, cognitive, and mental functioning, severity of depression, levels of optimism and resilience, and self-rated successful aging. Next we did bivariate correlational analyses with self-rated successful aging as the dependent variable and with other subject characteristics as independent variables, covarying for age. We then performed multiple regression analyses using all the potential correlates to identify the best multivariable model of self-rated successful aging. Missing data were imputed according to the method of chained equations (23). There were no missing data for age, gender, and total score on the Telephone Interview for Cognitive Status. The measures of marital status, education, total score on the Life Orientation Test, total score on the Connor-Davison Resilience Scale, and self-rated successful aging each had missing data for fewer than 5% of the participants. The severity score on the 9-item Patient Health Questionnaire and scores for the physical and mental components of the Medical Outcomes Study 36-Item Short-Form Health Survey had missing data for 5%–6%. The Cognitive Failures Questionnaire total score had the highest level of missing data, at 14.4%.
We performed a least absolute shrinkage and selection operator (LASSO) variable selection procedure (24). In the multiple regression analysis, regression coefficients were made commensurate by standardizing each variable (subtracting the mean and dividing by the standard deviation). Independent variables were ranked by the order in which they entered the LASSO regression. The LASSO is an L1-norm penalized regression method; higher penalties include fewer variables. The penalty was chosen to minimize the Mallows Cp criterion (25) and was implemented by using the least-angles regression package in R (26). It may be noted that the LASSO does not attempt to maximize R2, so the reported R2 value is a valid assessment of the variance explained by the resulting model. Furthermore, we cross-checked these results by using a random forests regression procedure (27). The random forests procedure produces an out-of-bag estimate of R2 that is robust to generalization accuracy. We also explored placing all pairwise interactions in the regression search algorithm.
To control for type 1 errors due to multiple comparisons, we used a conservative alpha level of 0.005 (two-tailed) to define significance.
Results
Table 1 summarizes sociodemographic and other characteristics related to successful aging for each of the five age decades studied. The overall sample had a mean age of 77.3 years (SD=12.2), and the mean score for self-rated successful aging was 8.2 (SD=1.5). Older age was significantly associated with worse physical functioning (r=–0.35, N=945, p<0.001), objective cognitive functioning (r=–0.46, N=1,004, p<0.001), and subjective cognitive functioning (r=0.12, N=859, p=0.001), but it was also related to better mental functioning (r=0.12, N=945, p<0.001). Age was not related to the level of depression, optimism, or resilience. The bivariate associations of each potential correlate with self-rated successful aging are listed in Table 2.
Variable | Possible Range of Scores | Age 50–59 (N=122) | Age 60–69 (N=162) | Age 70–79 (N=193) | Age 80–89 (N=347) | Age 90–99 (N=182) | |||||
---|---|---|---|---|---|---|---|---|---|---|---|
N | % | N | % | N | % | N | % | N | % | ||
Female | 58 | 47.5 | 75 | 46.3 | 96 | 49.7 | 177 | 51.0 | 82 | 45.1 | |
Currently married | 74 | 60.7 | 104 | 64.2 | 116 | 60.1 | 143 | 41.3 | 54 | 30.3 | |
Education | |||||||||||
High school | 8 | 6.6 | 30 | 18.5 | 55 | 28.5 | 96 | 27.7 | 50 | 28.2 | |
Some college | 86 | 70.5 | 90 | 55.6 | 99 | 51.3 | 197 | 56.8 | 97 | 54.8 | |
Postbaccalaureate | 28 | 23.0 | 42 | 25.9 | 39 | 20.2 | 53 | 15.3 | 30 | 16.9 | |
Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | ||
Age (years) | 55.9 | 2.3 | 64.4 | 2.8 | 75.0 | 2.5 | 84.3 | 2.4 | 92.4 | 1.9 | |
Physical functioning: score on physical component of Medical Outcomes Study 36-Item Short-Form Health Survey | 0–100 | 49.3 | 9.7 | 48.0 | 10.1 | 44.3 | 10.9 | 41.7 | 10.4 | 37.3 | 10.1 |
Objective cognitive functioning: total score on Telephone Interview for Cognitive Status | 0–50 | 36.5 | 3.7 | 35.8 | 4.5 | 32.8 | 5.1 | 32.1 | 4.8 | 28.8 | 5.1 |
Subjective cognitive functioning: total score on 25-item Cognitive Failures Questionnaireb | 0–100 | 27.5 | 11.5 | 25.4 | 11.7 | 31.2 | 12.7 | 30.4 | 10.8 | 30.7 | 11.7 |
Mental functioning: score on mental component of Medical Outcomes Study 36-Item Short-Form Health Survey | 0–100 | 52.5 | 9.3 | 55.5 | 6.6 | 55.2 | 8.8 | 55.3 | 8.0 | 56.4 | 7.2 |
Depression: severity score on 9-item Personal Health Questionnaireb | 0–27 | 3.0 | 4.2 | 2.4 | 3.7 | 2.4 | 3.5 | 2.6 | 3.3 | 2.5 | 2.6 |
Optimism: total score on Life Orientation Test–Revised | 6–30 | 22.8 | 4.3 | 23.9 | 3.6 | 22.7 | 3.1 | 22.8 | 3.4 | 22.7 | 3.1 |
Resilience: total score on 10-item Connor-Davidson Resilience Scale | 0–40 | 31.4 | 6.4 | 32.1 | 6.2 | 30.8 | 7.0 | 30.8 | 5.9 | 31.1 | 6.3 |
Self-rating of successful agingc | 0–10 | 7.7 | 1.8 | 8.1 | 1.6 | 8.2 | 1.4 | 8.2 | 1.3 | 8.6 | 1.4 |
Correlate | Regression Coefficient | Analysis | Variance | ||
---|---|---|---|---|---|
F | df | p | R2 | ||
Gender | 0.1 | 1, 1003 | 0.74 | 0.026 | |
Marital status | 3.3 | 1, 1003 | 0.07 | 0.035 | |
Education | 3.1 | 10, 994 | <0.001 | 0.043 | |
Coefficient | t | df | p | R2 | |
Agea | 0.020 | 5.4 | 1,004 | <0.001 | 0.027 |
Physical functioning: score on physical component of Medical Outcomes Study 36-Item Short-Form Health Survey | 0.056 | 13.6 | 1,003 | <0.001 | 0.177 |
Objective cognitive functioning: total score on Telephone Interview for Cognitive Status | 0.033 | 3.4 | 1,003 | 0.001 | 0.037 |
Subjective cognitive functioning: total score on 25-item Cognitive Failures Questionnaireb | –0.030 | –7.9 | 1,003 | <0.001 | 0.083 |
Mental functioning: score on mental component of Medical Outcomes Study 36-Item Short-Form Health Survey | 0.049 | 8.9 | 1,003 | <0.001 | 0.097 |
Depression: severity score on 9-item Personal Health Questionnaireb | –0.166 | –13.3 | 1,003 | <0.001 | 0.172 |
Optimism: total score on Life Orientation Test–Revised | 0.135 | 10.7 | 1,003 | <0.001 | 0.125 |
Resilience: total score on 10-item Connor-Davidson Resilience Scale | 0.098 | 14.8 | 1,003 | <0.001 | 0.200 |
The best multiple regression model achieved with all the variables as potential correlates of self-rated successful aging is shown in Table 3. This model accounted for 30% of the variance. We cross-checked these results using a random forests regression procedure (27). In a model trained with the same variables obtained from the LASSO analysis, random forests produced an out-of-bag estimate of R2 of 27%, indicating that the estimate was not biased upward from overfitting the data. Our model included resilience, depression, physical health, and age, entering the regression model in that order. Notably, cognitive impairment was not significant in the multiple regression analysis. Thus, while we did not find interactive effects, we did find independent additive effects in multiple regression analyses. These effects are displayed in Figure 2, which illustrates scores for self-rated successful aging for pairs of variables by tertiles. These plots demonstrate relative effect sizes of different correlates of self-rated successful aging when the analysis controlled for other variables. Thus, Figure 2a shows that
Variableb | Estimate | SE | p |
---|---|---|---|
Resilience: total score on 10-item Connor-Davidson Resilience Scale | 0.396 | 0.044 | <0.0001 |
Depression: severity score on 9-item Personal Health Questionnairec | 0.258 | 0.047 | <0.0001 |
Physical functioning: score on physical component of Medical Outcomes Study 36-Item Short-Form Health Survey | 0.405 | 0.044 | <0.0001 |
Age | 0.397 | 0.042 | <0.0001 |
Discussion
Contrary to our hypothesis, older age was associated with higher self-ratings of successful aging, despite worse physical and cognitive functioning. The best multivariate model included greater resilience, lower depression, better physical health, and older age. Even though in bivariate analyses, self-rated successful aging was associated with physical health and cognitive functioning, which typically decline with age, older age was associated with higher self-rated successful aging. Resilience and depression seemed to have effects on successful aging with magnitudes that seemed at least comparable to that of physical health (Figure 2).
The SAGE investigation builds on the foundations of prior research into psychosocial aspects of successful aging (5, 14, 28, 29). To our knowledge, this is the first study of self-rated successful aging to employ a large population-based sample of adults over 50 recruited with a structured multicohort design using list-assisted random-digit dialing procedures. Thus, except for the planned oversampling of adults over age 80, the present sample may be more representative of the broader community-dwelling population of older people than similarly aged samples of convenience. Also, in addition to assessing self-rated successful aging, participants were comprehensively characterized on self-reported physical and mental health and positive psychological traits, along with subjective and objective measures of cognitive functioning.
Our study has several limitations, especially the cross-sectional design and use of self-report-based assessments for most measures. Because of the cross-sectional nature of the data, a “potential survivor bias,” and more specifically a “community survival effect,” may confound interpretation of age effects. Since we excluded people in nursing homes or other institutions, it is possible that the positive association between greater self-rated successful aging and older age may be due to attrition of low-functioning (with low self-rated successful aging) older adults due to death or institutionalization. It should be noted, however, that in our sample, older age was associated with worse physical and cognitive functioning, i.e., our elderly group did not comprise exceptionally healthy seniors. Also, the survey response rate for people who completed our initial telephone interview was higher among 80–89-year-old individuals than in 50–59-year-old persons. Therefore, a survivor effect is unlikely to be the primary explanation for our findings. At the same time, the cross-sectional design prevents one from making causal inferences based on observed associations, e.g., whether higher resilience leads to greater self-rated successful aging or vice versa. Longitudinal follow-up may help specify causal relationships.
Another study limitation is that the data were collected through self-report measures (except for the Telephone Interview for Cognitive Status). It may be argued, for example, that optimism and self-rated successful aging are both self-rated and highly interrelated. However, optimism was not significant in the multiple regression model of successful aging. With self-reports, it is important to consider the likely influence of a tendency to give socially desirable responses on the validity of the results. However, in an earlier study of 1,860 nonrandomly selected community-dwelling older women, when we used the Marlowe-Crowne Social Desirability Scale we did not find evidence for a social desirability bias in most of the self-report measures of successful aging, including self-rated successful aging and physical and cognitive functioning (30).
The relatively weak association between self-rated successful aging and objective cognitive functioning might be partially attributable to the use of the Telephone Interview for Cognitive Status, which is primarily a dementia screening measure. With a comprehensive neurocognitive battery, a stronger association between self-rated successful aging and objective cognitive functioning might have emerged.
Notwithstanding these limitations, our findings could be relevant to clinicians and researchers in at least three ways: modification of the attitude toward aging, use of self-rated successful aging as a meaningful outcome measure, and most important, the potential for enhancing successful aging by fostering resilience and treating or preventing depression. First, in terms of the attitude toward aging, most of the public discourse on population aging involves dire predictions and negative stereotypes. Yet the subjective experience of older people in our study seemed to improve with age even in the midst of physical and cognitive declines. The apparent trajectory of self-rated successful aging in middle and old age parallels published findings on well-being. Negative emotions have been reported to display a curvilinear relationship through the life course, with mental distress reaching a maximum in middle age and then decreasing progressively into later life, with an inverse change in positive emotions (31). This finding of a counterintuitive increase in well-being with aging persists after accounting for the confounding influences of cohort, income, education, and marriage. Possible explanations for this paradoxical result include acceptance of physical limitations (32, 33), contentedness with overall accomplishments in life (34), a more realistic appraisal of one’s own strengths and limitations (31), reduced preoccupation with social comparison (peer pressure), and greater emotional stability (14, 35). Clinicians can help reduce societal ageism through their optimistic approach to the care of seniors. Further research on how older adults develop and maintain positive self-appraisals in the presence of biological declines may also inform similar adaptations across the lifespan.
Second, the present study illustrates the potential value of a subjective measure of overall functioning in later life, i.e., self-rated successful aging. Subjective outcomes are gaining increasing credence in intervention and services research (4). At the individual level, self-rated health has been found to be a significant predictor of morbidity and mortality in old age (36). At the population level, a large study of U.S. citizens living in different parts of the country (37) correlated data on self-rated quality of well-being with objective indicators of quality of life—such as cost of living, environmental “greenness,” air quality, and local taxes—among people in the same region. The authors found a strong region-by-region match between subjective and objective well-being, attesting to the validity of self-reports of personal constructs. The subjective appraisal of overall aging by older adults themselves may be an important outcome in clinical practice and intervention research. For this to be useful as a patient-centered outcome, future longitudinal research would need to determine the responsiveness of self-rated successful aging to change and its applicability across cultures and population subgroups, including people with mental illnesses.
Finally, an important implication of the present study relates to the finding that resilience and depression were significantly associated with self-rated successful aging, with an effect comparable in size to that for physical health. While no causality can be inferred from these cross-sectional data, it is possible to speculate that increasing resilience and reducing depression might have effects on successful aging as strong as the effects of reducing physical disability. This finding points to an important role for psychiatry in enhancing successful aging in older adults, even in those with physical disabilities (38). Resilience is often described in response to acute stressors, yet it may be an important aspect of maintaining well-being in the context of losses in functioning with aging (39). To date there has been only limited research focused on enhancing positive psychological traits, such as resilience (40, 41). We found a significant association between depression and self-rated successful aging despite the relatively low levels of depression in our sample, i.e., only a few of the respondents likely would have met the DSM-IV-TR criteria for major depression. Prior literature suggests that older adults are more likely to have subsyndromal depression than major depressive disorder (42). The fact that even low levels of depressive symptoms appeared to influence self-rated successful aging suggests the potential value of interventions to treat or prevent subsyndromal depression in order to enhance successful aging. Greater understanding of the psychosocial and neurobiological underpinnings of the interaction between resilience and depression in older age (43) may identify routes to promote successful aging.
In conclusion, the present results have important implications for psychiatry and aging. Perfect physical health is neither necessary nor sufficient for successful aging as defined by the older adults themselves. Their holistic self-appraisal involves strong emphasis on psychological factors such as resilience, optimism, and well-being, along with an absence of depression. Combined with evidence showing that traits such as resilience and optimism are associated with greater longevity and reduced physical morbidity (11), with the reverse being true for depression, our findings suggest that psychiatry should take center stage within medicine and health care. Paralleling the recent positive psychology movement (44), the time may be ripe for a “positive psychiatry” movement (38).
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