Fluphenazine Enanthate and Fluphenazine Decanoate: A Comparison of Their Duration of Action and Motor Side Effects
Abstract
Fluphenazine enanthate and fluphenazine decanoate—two long-acting neuroleptics—were administered in a controlled comparative study to 30 patients with acute psychoses of different character and origin. The study compared the duration of action and affinity for the extrapyramidal system of the two drugs. The decanoate ester acted longer than the enanthate ester and provoked fewer motor side effects. Since these side effects greatly reduce the patient's motivation to cooperate in taking depot medication, the decanoate ester is to be preferred.
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