Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Pace, T. W.W. Articles by Heim, C. M. Search for Related Content PubMed Citation Articles by Pace, T. W.W. Articles by Heim, C. M. Depression Stress

Increased Stress-Induced Inflammatory Responses in Male Patients With Major Depression and Increased Early Life Stress

OBJECTIVE: The authors sought to determine innate immune system activation following psychosocial stress in patients with major depression and increased early life stress. METHOD: Plasma interleukin (IL)-6, lymphocyte subsets, and DNA binding of nuclear factor (NF)-kB in peripheral blood mononuclear cells were compared in medically healthy male subjects with current major depression and increased early life stress (N=14) versus nondepressed male comparison subjects (N=14) before and after completion of the Trier Social Stress Test. RESULTS: Trier Social Stress Test-induced increases in IL-6 and NF-B DNA-binding were greater in major depression patients with increased early life stress and independently correlated with depression severity, but not early life stress. Natural killer (NK) cell percentages also increased following stress. However, there were no differences between groups and no correlation between NK cell percentage and stress-induced NF-B DNA-binding or IL-6. CONCLUSIONS: Male major depression patients with increased early life stress exhibit enhanced inflammatory responsiveness to psychosocial stress, providing preliminary indication of a link between major depression, early life stress and adverse health outcomes in diseases associated with inflammation.

This article has been cited by other articles:

				G. N. Neigh, C. F. Gillespie, and C. B. Nemeroff The Neurobiological Toll of Child Abuse and Neglect Trauma Violence Abuse, October 1, 2009; 10(4): 389 - 410. [Abstract] [PDF]

				F. S. Dhabhar A hassle a day may keep the pathogens away: The fight-or-flight stress response and the augmentation of immune function Integr. Comp. Biol., September 1, 2009; 49(3): 215 - 236. [Abstract] [Full Text] [PDF]

				G. E. Miller, E. Chen, A. K. Fok, H. Walker, A. Lim, E. F. Nicholls, S. Cole, and M. S. Kobor Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling PNAS, August 25, 2009; 106(34): 14716 - 14721. [Abstract] [Full Text] [PDF]

				M. B. Wilkinson, G. Xiao, A. Kumar, Q. LaPlant, W. Renthal, D. Sikder, T. J. Kodadek, and E. J. Nestler Imipramine Treatment and Resiliency Exhibit Similar Chromatin Regulation in the Mouse Nucleus Accumbens in Depression Models J. Neurosci., June 17, 2009; 29(24): 7820 - 7832. [Abstract] [Full Text] [PDF]

				J. Warnick, C. Huang, E. Acevedo, and K. Sufka Modelling the anxiety-depression continuum in chicks J Psychopharmacol, March 1, 2009; 23(2): 143 - 156. [Abstract] [PDF]

				M. B. Howren, D. M. Lamkin, and J. Suls Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis Psychosom Med, February 1, 2009; 71(2): 171 - 186. [Abstract] [Full Text] [PDF]

				M. Hamer, G. J. Molloy, and E. Stamatakis Psychological distress as a risk factor for cardiovascular events: pathophysiological and behavioral mechanisms. J. Am. Coll. Cardiol., December 16, 2008; 52(25): 2156 - 2162. [Abstract] [Full Text] [PDF]

				A. Danese, T. E. Moffitt, C. M. Pariante, A. Ambler, R. Poulton, and A. Caspi Elevated Inflammation Levels in Depressed Adults With a History of Childhood Maltreatment Arch Gen Psychiatry, April 1, 2008; 65(4): 409 - 415. [Abstract] [Full Text] [PDF]

				A. H. Miller, S. Ancoli-Israel, J. E. Bower, L. Capuron, and M. R. Irwin Neuroendocrine-Immune Mechanisms of Behavioral Comorbidities in Patients With Cancer J. Clin. Oncol., February 20, 2008; 26(6): 971 - 982. [Abstract] [Full Text] [PDF]

				A. H. Miller and C. L. Raison Immune System Contributions to the Pathophysiology of Depression Focus, January 1, 2008; 6(1): 36 - 45. [Abstract] [Full Text] [PDF]

				J. K. Kiecolt-Glaser, M. A. Belury, K. Porter, D. Q. Beversdorf, S. Lemeshow, and R. Glaser Depressive Symptoms, omega-6:omega-3 Fatty Acids, and Inflammation in Older Adults Psychosom Med, April 1, 2007; 69(3): 217 - 224. [Abstract] [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2006 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us