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Am J Psychiatry 1982; 139:741-746
Copyright © 1982 by American Psychiatric Association
Aggression, suicide, and serotonin: relationships to CSF amine metabolites
GL Brown, MH Ebert, PF Goyer, DC Jimerson, WJ Klein, WE Bunney and FK Goodwin
In an earlier, separate study, the authors found that human aggression and
suicide (a specific aggression-related behavior) were associated with lower
levels of CSF 5-hydroxyindoleacetic acid (5-HIAA), a serotonin metabolite.
That study focused on subjects with personality disorders without affective
illness. In the present study they examine the life history of aggression
and history of suicidal behavior in 12 subjects with borderline personality
disorders without major affective disorder. Histories of aggressive
behaviors and of suicide attempts were significantly associated with each
other, and each was significantly associated with lower 5-HIAA levels.
Altered serotonin metabolism may be a highly significant contributing
factor to these behaviors in whatever diagnostic group they occur.
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