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American Journal of Psychiatry

Volume 176, Issue 5

May 2019
Cover: A cellular model for the rapid and sustained behavioral actions of ketamine reported by Deyama et al. (p. 388) showing regulation of vascular endothelial growth factor (VEGF) release and fetal liver kinase 1 (Flk-1) signaling.
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Editor's Note
May 2019
Improving the Lives of Patients With Major Depression by Focusing on New Treatment Approaches
  • Pages:329–330
  • Published Online:1 May 2019

https://doi.org/10.1176/appi.ajp.2019.19030283

Editorials
May 2019
Heterogeneity in Major Depressive Disorder: Lessons From Developmental Research on Irritability
  • Pages:331–332
  • Published Online:1 May 2019

https://doi.org/10.1176/appi.ajp.2019.19020214

May 2019
New Insights Into the Mechanisms of Ketamine’s Antidepressant Effects: Understanding the Role of VEGF in Mediating Plasticity Processes
  • Pages:333–335
  • Published Online:1 May 2019

https://doi.org/10.1176/appi.ajp.2019.19030282

Commentary
May 2019
Opportunities for Improving Access to Evidence-Based Treatments of Depression
  • Pages:336–337
  • Published Online:1 May 2019

https://doi.org/10.1176/appi.ajp.2019.19010098

Perspectives in Global Mental Health
May 2019
The Concept of Mania in Traditional Andean Culture
  • Pages:338–340
  • Published Online:1 May 2019

https://doi.org/10.1176/appi.ajp.2018.18060681

Images in Psychiatry
May 2019
Vladimir Horowitz (1903–1989)
  • Page:341
  • Published Online:1 May 2019

https://doi.org/10.1176/appi.ajp.2018.18060672

Reviews and Overviews
May 2019
Scientific Issues Relevant to Improving the Diagnosis, Risk Assessment, and Treatment of Major Depression
  • Pages:342–347
  • Published Online:1 May 2019

https://doi.org/10.1176/appi.ajp.2019.19030273

Preview Abstract
Articles
Audio
May 2019
General Predictors and Moderators of Depression Remission: A VAST-D Report
  • Pages:348–357
  • Published Online:5 April 2019

https://doi.org/10.1176/appi.ajp.2018.18091079

Preview Abstract
AudioVideo
May 2019
Irritability and Its Clinical Utility in Major Depressive Disorder: Prediction of Individual-Level Acute-Phase Outcomes Using Early Changes in Irritability and Depression Severity
  • Pages:358–366
  • Published Online:29 March 2019

https://doi.org/10.1176/appi.ajp.2018.18030355

Preview Abstract
May 2019
Trajectories of Response to Dorsolateral Prefrontal rTMS in Major Depression: A THREE-D Study
  • Pages:367–375
  • Published Online:15 February 2019

https://doi.org/10.1176/appi.ajp.2018.18091096

Preview Abstract
May 2019
No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples
  • Pages:376–387
  • Published Online:8 March 2019

https://doi.org/10.1176/appi.ajp.2018.18070881

Preview Abstract
Video
May 2019
Role of Neuronal VEGF Signaling in the Prefrontal Cortex in the Rapid Antidepressant Effects of Ketamine
  • Pages:388–400
  • Published Online:4 January 2019

https://doi.org/10.1176/appi.ajp.2018.17121368

Preview Abstract
May 2019
Single, Repeated, and Maintenance Ketamine Infusions for Treatment-Resistant Depression: A Randomized Controlled Trial
  • Pages:401–409
  • Published Online:29 March 2019

https://doi.org/10.1176/appi.ajp.2018.18070834

Preview Abstract
Letters to the Editor
May 2019
Explaining Naltrexone’s Interference With Ketamine’s Antidepressant Effect
  • Pages:410–411
  • Published Online:1 May 2019

https://doi.org/10.1176/appi.ajp.2019.19010044

May 2019
Rigorous Translational Models Are Key to Studying Ketamine’s Antidepressant Mechanism: Response to Wang and Kaplin
  • Page:412
  • Published Online:1 May 2019

https://doi.org/10.1176/appi.ajp.2019.19010044r

May 2019
Consumer Warning for Genetic Tests Claiming to Predict Response to Medications: Implications for Psychiatry
  • Pages:412–413
  • Published Online:1 May 2019

https://doi.org/10.1176/appi.ajp.2019.18121359

Books Received
May 2019
Books Received
  • Page:414
  • Published Online:1 May 2019

https://doi.org/10.1176/appi.ajp.2018.1760103

Correction
May 2019
Correction to Mackey et al.
  • Page:414
  • Published Online:1 May 2019

https://doi.org/10.1176/appi.ajp.2019.1765correction

Issue Highlights