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American Journal of Psychiatry

Volume 178, Issue 12

December 2021

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Editor's Note

December 2021

New Insights Into Major Depression and the Treatment of Bipolar Depression

Ned H. Kalin, M.D.

Pages:1071–1074
Published Online:2 December 2021

https://doi.org/10.1176/appi.ajp.2021.21101042

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Editorials

December 2021

Slowly Working Toward More Treatments for Depression in Bipolar II Disorder

Michael J. Ostacher, M.D., M.P.H.

Pages:1075–1076
Published Online:2 December 2021

https://doi.org/10.1176/appi.ajp.2021.21101028

Full text
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December 2021

Increased Inflammation in Depression: A Little in All, or a Lot in a Few?

Carmine M. Pariante, M.D., Ph.D.

Pages:1077–1079
Published Online:2 December 2021

https://doi.org/10.1176/appi.ajp.2021.21101043

First Page
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December 2021

Coordinate Network Mapping: An Emerging Approach for Morphometric Meta-Analysis

Joseph J. Taylor, M.D., Ph.D.,
Shan H. Siddiqi, M.D.,
Michael D. Fox, M.D., Ph.D.

Pages:1080–1081
Published Online:2 December 2021

https://doi.org/10.1176/appi.ajp.2021.21100987

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Reviews and Overviews

December 2021

Neuromodulation Strategies for the Treatment of Depression

Susan K. Conroy, M.D., Ph.D.,
Paul E. Holtzheimer, M.D.

Pages:1082–1088
Published Online:2 December 2021

https://doi.org/10.1176/appi.ajp.2021.21101034

Abstract
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For many decades, psychiatric treatment has been primarily guided by two major paradigms of psychopathology: a neurochemical paradigm leading to the development of medications and a psychological paradigm resulting in the development of psychotherapies. A ...

Articles

CMEAudio

December 2021

Association of ECT With Risks of All-Cause Mortality and Suicide in Older Medicare Patients

Taeho Greg Rhee, Ph.D.,
Kyaw Sint, Ph.D.,
Mark Olfson, M.D., M.P.H.,
Tobias Gerhard, Ph.D.,
Susan H. Busch, Ph.D.,
Samuel T. Wilkinson, M.D.

Pages:1089–1097
Published Online:10 September 2021

https://doi.org/10.1176/appi.ajp.2021.21040351

Abstract
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Objective: This observational study examined the effects of electroconvulsive therapy (ECT) on suicide and all-cause mortality risk in older psychiatric patients. Methods: Participants were Medicare-insured psychiatric inpatients age 65 or older. ...

December 2021

Efficacy and Safety of Lumateperone for Major Depressive Episodes Associated With Bipolar I or Bipolar II Disorder: A Phase 3 Randomized Placebo-Controlled Trial

Joseph R. Calabrese, M.D.,
Suresh Durgam, M.D.,
Andrew Satlin, M.D.,
Kimberly E. Vanover, Ph.D.,
Robert E. Davis, Ph.D.,
Richard Chen, Ph.D.,
Susan G. Kozauer, M.D.,
Sharon Mates, Ph.D.,
Gary S. Sachs, M.D.

Pages:1098–1106
Published Online:23 September 2021

https://doi.org/10.1176/appi.ajp.2021.20091339

Abstract
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Objective: In a phase 3 randomized double-blind placebo-controlled study, the authors investigated the efficacy and safety of 42 mg/day of lumateperone in patients with bipolar I or bipolar II disorder experiencing a major depressive episode. Methods: ...

CME

December 2021

Association Between Systemic Inflammation and Individual Symptoms of Depression: A Pooled Analysis of 15 Population-Based Cohort Studies

Philipp Frank, M.Sc.,
Markus Jokela, Ph.D.,
G. David Batty, Ph.D., D.Sc.,
Dorina Cadar, Ph.D.,
Andrew Steptoe, D.Phil., F.Med.Sci.,
Mika Kivimäki, Ph.D., F.Med.Sci.

Pages:1107–1118
Published Online:14 October 2021

https://doi.org/10.1176/appi.ajp.2021.20121776

Abstract
Full text
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Supplement
CME

Preview Abstract

Objective: Evidence from anti-inflammatory drug trials for the treatment of depression has been inconsistent. This may be ascribed to the differing symptom-specific effects of inflammation. Accordingly, the authors explored the associations between ...

CME

December 2021

Coordinate-Based Network Mapping of Brain Structure in Major Depressive Disorder in Younger and Older Adults: A Systematic Review and Meta-Analysis

Peter Zhukovsky, Ph.D.,
John A.E. Anderson, Ph.D.,
Gillian Coughlan, Ph.D.,
Benoit H. Mulsant, M.D., M.S.,
Andrea Cipriani, M.D., Ph.D.,
Aristotle N. Voineskos, M.D., Ph.D.

Pages:1119–1128
Published Online:14 October 2021

https://doi.org/10.1176/appi.ajp.2021.21010088

Abstract
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Objective: Structural neuroimaging findings in younger and older adults with major depressive disorder (MDD) are highly heterogeneous, possibly as a result of methodological limitations, lack of distinction between MDD and late-life depression (LLD), or ...

Letters to the Editor

December 2021

Recommendations for the Usage of Ketamine and Esketamine

Victor I. Reus, M.D.

Page:1129
Published Online:2 December 2021

https://doi.org/10.1176/appi.ajp.2021.21060555

Full text
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December 2021

Ketamine After Two Antidepressants?

Jeffrey A. Mattes, M.D.

Page:1129
Published Online:2 December 2021

https://doi.org/10.1176/appi.ajp.2021.21060576

Full text
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Supplement

December 2021

Mechanisms of Action of Ketamine and Esketamine

Alan F. Schatzberg, M.D.

Page:1130
Published Online:2 December 2021

https://doi.org/10.1176/appi.ajp.2021.21060653

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December 2021

Ketamine and Esketamine for Treatment-Resistant Depression: Response to Reus, Mattes, and Schatzberg

Roger S. McIntyre, M.D.

Pages:1130–1132
Published Online:2 December 2021

https://doi.org/10.1176/appi.ajp.2021.21060653r

First Page
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Appreciation

December 2021

Reviewers for The American Journal of Psychiatry

Pages:1133–1137
Published Online:2 December 2021

https://doi.org/10.1176/appi.ajp.2021.1781201

First Page
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