Increased Medial Orbitofrontal and Amygdala Activation: Evidence for a Systems-Level Endophenotype of Bipolar I Disorder
- Julia Linke,
M.S. , - Andrea Victoria King,
M.S. , - Marcella Rietschel,
M.D. , - Jana Strohmaier,
M.S. , - Michael Hennerici,
M.D. , - Achim Gass,
M.D. , - Andreas Meyer-Lindenberg,
M.D., Ph.D. , and - Michèle Wessa,
Ph.D.
From the Departments of Cognitive and Clinical Neuroscience, Genetic Epidemiology in Psychiatry, and Psychiatry and Psychotherapy at the Central Institute of Mental Health in Mannheim, Germany; the Neurological Clinic at the University Hospital Mannheim, Mannheim, Germany; and the Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, University of Heidelberg, Heidelberg, Germany.
From the Departments of Cognitive and Clinical Neuroscience, Genetic Epidemiology in Psychiatry, and Psychiatry and Psychotherapy at the Central Institute of Mental Health in Mannheim, Germany; the Neurological Clinic at the University Hospital Mannheim, Mannheim, Germany; and the Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, University of Heidelberg, Heidelberg, Germany.
From the Departments of Cognitive and Clinical Neuroscience, Genetic Epidemiology in Psychiatry, and Psychiatry and Psychotherapy at the Central Institute of Mental Health in Mannheim, Germany; the Neurological Clinic at the University Hospital Mannheim, Mannheim, Germany; and the Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, University of Heidelberg, Heidelberg, Germany.
From the Departments of Cognitive and Clinical Neuroscience, Genetic Epidemiology in Psychiatry, and Psychiatry and Psychotherapy at the Central Institute of Mental Health in Mannheim, Germany; the Neurological Clinic at the University Hospital Mannheim, Mannheim, Germany; and the Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, University of Heidelberg, Heidelberg, Germany.
From the Departments of Cognitive and Clinical Neuroscience, Genetic Epidemiology in Psychiatry, and Psychiatry and Psychotherapy at the Central Institute of Mental Health in Mannheim, Germany; the Neurological Clinic at the University Hospital Mannheim, Mannheim, Germany; and the Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, University of Heidelberg, Heidelberg, Germany.
From the Departments of Cognitive and Clinical Neuroscience, Genetic Epidemiology in Psychiatry, and Psychiatry and Psychotherapy at the Central Institute of Mental Health in Mannheim, Germany; the Neurological Clinic at the University Hospital Mannheim, Mannheim, Germany; and the Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, University of Heidelberg, Heidelberg, Germany.
From the Departments of Cognitive and Clinical Neuroscience, Genetic Epidemiology in Psychiatry, and Psychiatry and Psychotherapy at the Central Institute of Mental Health in Mannheim, Germany; the Neurological Clinic at the University Hospital Mannheim, Mannheim, Germany; and the Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, University of Heidelberg, Heidelberg, Germany.
From the Departments of Cognitive and Clinical Neuroscience, Genetic Epidemiology in Psychiatry, and Psychiatry and Psychotherapy at the Central Institute of Mental Health in Mannheim, Germany; the Neurological Clinic at the University Hospital Mannheim, Mannheim, Germany; and the Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, University of Heidelberg, Heidelberg, Germany.
Supplemental Material
appi.ajp.2011.11050711_ds001.pdf (365 KB)