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Amitriptyline-perphenazine overdose producing delayed hypomania in manic-depressive illness

Published Online:https://doi.org/10.1176/ajp.132.8.870

The authors describe a 26-year-old woman who became hypomanic after awakening from a semicomatose state induced by an overdose of amitriptyline-perphenazine (Triavil). She had been depressed and had a strong family history of manic-depressive illness. The case is reported to support previous evidence that dopamine is a mediator for mania.

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