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A Comparison of Lithium Carbonate and Chlorpromazine in Mania

Published Online:https://doi.org/10.1176/ajp.127.3.351

Thirteen manic patients were treated with lithium carbonate and ten manic patients with chlorpromazine in a double-blind, randomly selected drug trial. Lithium carbonate proved superior to chlorpromazine on all six parameters selected from an objective rating scale. The author discusses the problems militating against a valid research trial utilizing these medications in this type of patient.

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