Are Antidepressants Better Than Placebo?
Abstract
A study of 203 depressed outpatients who were randomly assigned to one of seven active drug treatment groups or to a placebo group demonstrated that the inclusion of a placebo group is essential for valid assessment of the efficacy of antidepressant drugs. Although all groups improved on depression ratings in relation to their own baselines, only one group achieved a level of improvement that was significantly better than that of the placebo group.
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