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Published Online:https://doi.org/10.1176/ajp.118.4.354

Imipramine and nialamide were found to be comparable as measured by psychiatrist's clinical ratings of over-all improvement in patients with depressive symptoms. On measures of specffic behavioral factors on the MACC scale the two drug groups were differentiated by improved motility in patients on imipramine and by positive changes in affect in patients receiving nialamide during the first 6 weeks of drug administration.

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