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CLINICAL AND ELECTROENCEPHALOGRAM INVESTIGATION ON LARGACTIL IN PSYCHOSIS (PRELIMINARY STUDY)

Published Online:https://doi.org/10.1176/ajp.112.10.788

1. Experimental investigations have been carried out with Largactil on chronic and acute mental patients.

2. The over-all improvement in chronic cases was 69% and in acute cases 60%.

3. However, the transitory effects in acute cases indicate that while Largactil is extremely valuable in chronic psychosis, in acute psychotic breakdowns, it has value only as a sedative.

4. Electroencephalogram investigations showed that Largactil markedly decreases the muscle artefacts, decreases the frequency, and increases the voltage, causing a mild progressive synchronization and, in epileptics, it lessens the convulsive threshold.

5. In spastics it decreases spasticity through intravenous route, as tested by electromyogram.

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