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Published Online:https://doi.org/10.1176/ajp.106.9.660

A series of studies have been carried out in schizophrenic patients and normal controls that indicate that (1) there is a reduction of tolerance to glucose in this psychosis; (2) the response of the adrenal cortex to stimulation by the ingestion of glucose is generally deficient as exemplified by measurements of various blood and urinary variables known to be pertinent to adreno-cortical activation.

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