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Published Online:https://doi.org/10.1176/ajp.114.12.1087

I should like to conclude by a restatement of the principles of therapy submitted for your consideration and which have been illustrated by several clinical examples.

1. Affects, moods or emotions are psycho-physiological states which tend to augment or decrease pathophysiological states.

2. The interaction of pharmacological agents with certain affects or emotions may be synergistic or antagonistic.

3. A patient reacts to his disease, to his treatment, and to his physician with manifest psychological, cultural, and—for want of a better term—physiological regression. Where the regression is not manifest there are obvious pathological efforts of the patient to obscure it.

4. By means of iatrogenically induced regression it is possible to bring about new affects or mood states.

5. The bodily functions which are psycho-physiologically excited or inhibited by the regression or the defenses against it either increase or oppose the pathophysiology of the disease.

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